Corrigendum to “Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy”

Moastafa, Tarek M.; El-Sissy, Alaa El-Din Elsayed; El-Saeed, Gehan K; Koura, M

doi:10.1155/2015/424603

Cited by 3 publications

(2 citation statements)

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“…In previous studies, the growth and development of colorectal tumors were proven to be highly related to abnormal regulation of cell proliferation, apoptosis, cell cycle arrest, and angiogenesis. − Lactoferrin suppresses cell proliferation, induces cell apoptosis, and down-regulates the expression of the pro-inflammatory cytokines. − Cytotoxic thymus-dependent lymphocytes (T cells) were also found to be the antitumor effector of lactoferrin, which was proven to enhance cell immune activity and Type I helper T cells (Th1) response, to activate natural killer (NK) cells and increase the sensitivity of tumor cells to NK cells. − Lactoferrin can inhibit proliferation of several kinds of tumor cells, and it was reported that the increased oncogenicity of human cervical endometrium was related to down-regulation of lactoferrin, accompanied by increased tumor cell proliferation . Rado found there was no mRNA expression of lactoferrin in the cells of promyelocytic leukemia and myeloblastic leukemia, indicating that the lack of lactoferrin in neutrophile granulocytes might cause abnormal proliferation of white blood cells in patients with leukemia .…”

Section: Introductionmentioning

confidence: 99%

Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model

Wang

et al. 2017

J. Agric. Food Chem.

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To investigate the effect and potential mechanisms of lactoferrin on colon cancer cells and tumors, HT29 and HCT8 cells were exposed to varying concentrations of lactoferrin, and the impacts on cell proliferation, migration, and invasion were observed. Cell proliferation test showed that high dosage of lactoferrin (5-100 mg/mL) inhibited cell viability in a dose-dependent manner, with the 50% concentration of inhibition at 81.3 ± 16.7 mg/mL and 101 ± 23.8 mg/mL for HT29 and HCT8 cells, respectively. Interestingly, migration and invasion of the cells were inhibited dramatically by 20 mg/mL lactoferrin, consistent with the significant down regulation of VEGFR2, VEGFA, pPI3K, pAkt, and pErk1/2 proteins. HT29 was chosen as the sensitive cell line to construct a tumor-bearing nude mice model. Notably, HT29 tumor weight was greatly reduced in both the lactoferrin group (26.5 ± 6.7 mg) and the lactoferrin/5-Fu group (14.5 ± 5.1 mg), compared with the control one (39.3 ± 6.5 mg), indicating that lactoferrin functioned as a tumor growth inhibitor. Considering lactoferrin also reduced the growth of blood vessels and the degree of malignancy, we concluded that HT29 tumors were effectively suppressed by lactoferrin, which might be achieved by regulation of phosphorylation from various kinases and activation of the VEGFR2-PI3K/Akt-Erk1/2 pathway.

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Section: Introductionmentioning

confidence: 99%

Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model

Wang

et al. 2017

J. Agric. Food Chem.

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“…Importantly, Lf was also well-tolerated in the clinical trials, with no serious side-effects being observed, while signs of immunomodulation were detected [ 21 , 22 , 23 , 24 ]. Moreover, when given in combination with chemotherapeutics, bLf was found to minimize side effects such as anemia and mucositis [ 27 ]. Accordingly, both the European Food Safety Authority (EFSA) [ 28 ] and the US Food and Drug Administration (FDA) [ 29 ] have recognized Lf as safe for various applications.…”

Section: A Box Full Of Surprisesmentioning

confidence: 99%

Plasmalemmal V-ATPase as a Potential Biomarker for Lactoferrin-Based Anticancer Therapy

2022

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Lactoferrin (Lf) is a milk-derived protein with well-recognized potential as a therapeutic agent against a wide variety of cancers. This natural protein exhibits health-promoting effects and has several interesting features, including its selectivity towards cancer cells, good tolerability in humans, worldwide availability, and holding a generally recognized as safe (GRAS) status. To prompt the rational clinical application of this promising anticancer compound, previous works aimed to unveil the molecular mechanisms underlying its selective anticancer activity, where plasmalemmal V-ATPase was identified as an Lf target in cancer cells. V-ATPase is a proton pump critical for cellular homeostasis that migrates to the plasma membrane of highly metastatic cancer cells contributing to the acidity of the tumor microenvironment. Cancer cells were found to be susceptible to Lf only when this proton pump is present at the plasma membrane. Plasmalemmal V-ATPase can thus be an excellent biomarker for driving treatment decisions and forecasting clinical outcomes of Lf-based anticancer strategies. Future research endeavors should thus seek to validate this biomarker by thorough preclinical and clinical studies, as well as to develop effective methods for its detection under clinical settings.

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Convergence Study on Remineralization Effect of fTCP and CPP-ACP using QLF-D

Kang¹,

Lee²

2016

Journal of the Korea Convergence Society

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• 주제어 : CPP-ACP, fTCP, 재광화, 인공우식병소, QLF-D AbstractThis study was to evaluate the change of mineral loss of fTCP and CPP-ACP in artificial caries lesions using QLF-D to compare the remineralization effect of recently developed fTCP and CPP-ACP, which is widely used as a remineralization cream in current dental clinics. Bovine specimens used in this study formed the artificial caries lesion immersing in demineralization solution for 10 days and were divided randomly into the following two groups; Group 1-Tooth Mousse containing 10% CPP-ACP, Group 2-Clinpro Tooth Creme containing 950ppm NaF and fTCP. Two tooth paste were applied to the artificial caries lesion of specimens and they were immersed in artificial saliva for 1 week. Mineral loss of artificial caries lesion was evaluated by fluorescence loss (⊿F) values using QLF-D. QLF-D analysis showed that the ⊿F and ⊿Fmax value increased 2.65 and 6.63, respectively, in the Tooth Mousse group, and the mineral loss decreased statistically significantly(p<0.05). However, Clinpro Tooth Creme group had no statistically significant difference. ⊿Fmax value of Tooth Mousse group was statistically significant difference compared to the Clinpro Tooth Creme. Therefore, the Tooth Mousse containing 10% CPP-ACP is more effective than Clinpro Tooth Creme containing fTCP in the treatment of remineralization of artificial caries lesions.•

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Corrigendum to “Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy”

Cited by 3 publications

References 0 publications

Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model

Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model

Plasmalemmal V-ATPase as a Potential Biomarker for Lactoferrin-Based Anticancer Therapy

Convergence Study on Remineralization Effect of fTCP and CPP-ACP using QLF-D

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