Corrigendum to “structure–activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicity” (Bioorg. Med. Chem. Lett. 2000, 10, 119)

Jew, Sang‐sup; Yoo, Chi-hyoung; Lim, Doo-yeon; Kim, Heeman; Mook‐Jung, Inhee; Jung, Min Whan; Choi, Hayun; Jung, Young Hoon; Kim, Heedoo; Park, Hyeung‐geun

doi:10.1016/s0960-894x(00)00222-5

Cited by 3 publications

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“…It was reported that asiatic acid displayed a remarkable spectrum of biological activities such as antitumor [2,3], neuroprotective [4], anti-inflammatory, and antidepressant activities [5]. The preparation of derivatives of these compounds for further study has attracted a lot of attention due to these properties.…”

Section: Introductionmentioning

confidence: 99%

Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina

Gao

Dong

Gao

et al. 2015

Journal of Asian Natural Products Research

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Asiatic acid (1) is a natural triterpenoid isolated from Centella asiatica. This paper reports the microbial transformation of asiatic acid by an endophytic fungus Umbelopsis isabellina to obtain derivatives potentially useful for further studies. Incubation of asiatic acid with U. isabellina afforded two derivatives 2α,3β,7β, 23-tetrahydroxyurs-12-ene-28-oic acid (2) and 2α,3β,7β,23-tetrahydroxyurs-11-ene-28,13-lactone (3). The structures of these compounds were elucidated by spectral data. Compound 3 has formed an unusual lactone. These two products are new compounds. The possible transformation passway was also discussed.

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Section: Introductionmentioning

confidence: 99%

Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina

Gao

Dong

Gao

et al. 2015

Journal of Asian Natural Products Research

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Neuroprotective properties of compounds of vegetable origin: pentacyclic triterpenes

Orłowska-Majdak¹

2014

PSYCHIATR. PSYCHOL. KLIN.

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Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma

Huang

Gao

et al. 2018

Front. Neurosci.

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Asiatic acid (AA), a pentacyclic triterpene derived from the tropical medicinal plant Centella asiatica, has been widely used as an antioxidant and anti-inflammatory agent. Evidence regarding the neuroprotective properties of AA is emerging. However, the protective effects of AA and its mechanism in glaucoma are poorly understood. In the current study, we investigate the neuroprotective effect and mechanism of AA on retinal ganglion cells (RGCs) in a rat model of glaucoma. Elevated intraocular pressure (IOP) was induced in adult rats by injecting microspheres into the anterior chamber. AA was intravitreally injected into glaucomatous rats. RGC densities were analyzed by evaluating surviving RGC number of the retinal flatmounts and retinal sections, and the apoptotic cell number were evaluated by analyzing retinal sections. RGC function was assessed by measuring the photopic negative response (PhNR). Retinal Bcl-2, Bax, and cleaved caspase-3 expression were determined using a Simple Western System, real-time PCR and immunofluorescence staining. AA reduced the loss of RGCs and decreased the apoptotic RGC number. AA exerted neuroprotective effects and ameliorated retinal dysfunction in impaired RGCs in a rat model of glaucoma. AA protected RGCs by upregulating the expression of the antiapoptotic protein Bcl-2 and downregulating the expression of the pro-apoptotic proteins Bax and caspase-3. This study has provided important evidence indicating that AA may be a potential therapeutic agent for glaucoma.

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Corrigendum to “structure–activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicity” (Bioorg. Med. Chem. Lett. 2000, 10, 119)

Cited by 3 publications

References 0 publications

Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina

Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina

Neuroprotective properties of compounds of vegetable origin: pentacyclic triterpenes

Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma

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