Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]

Yoon, Taeyoung; Lee, Hong-Won

doi:10.1016/j.cbpa.2020.10.004

Cited by 2 publications

(2 citation statements)

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“…MicroRNAs (miRNAs) are ~ 19-24 nucleotides non-coding RNAs that post-transcriptionally regulate gene expression by binding to target messenger RNAs (mRNAs) [20]. miRNAs are powerful regulators of several cellular activities including cell growth, differentiation, development, and apoptosis [21,22]. An altered miRNA expression is associated with many human diseases [23].…”

Section: Discussionmentioning

confidence: 99%

In silico study identifies hub genes and regulatory network associated with the pathogenesis of Japanese Encephalitis Virus

Kumar

Chand

Azad

2023

Preprint

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Japanese encephalitis (JE) is a mosquito-borne viral disease caused by the Japanese encephalitis virus (JEV). Approximately 3 billion people from South-East Asia are at risk of this disease; however, the pathogenesis mediated by this virus is still elusive. Therefore, this study was undertaken to identify hub genes and regulator network associated with JE pathogenesis using several computational tools. Our data revealed VEGFA and WNT5A genes as major contributing factors for the development of primary stage of invasive JEV. These two genes were found to be regulated by transcription factor and miRNA targets from multiple databases. The analysis revealed that the activation of VEGFA and WNT5A is mediated by several transcription factors that include EGR1, EPAS1, ETS1, FOS, HIF1A and GLI3, GLI2, GLI1, respectively. Furthermore, we also identified several miRNAs that regulates the repression of VEGFA and WNT5A and also measured their seed pairing and binding free energy of gene-miRNAs interactions. The mathematical modelling supports the role of above mentioned miRNAs in the initiation of the regulatory pathogenesis in JEV. Additionally, we have shown that the type 1 and type 2 coherent and incoherent feed forward loops help to determine the VEGFA gene regulation by TFs and miRNAs. Altogether, this study demonstrates the regulation of JEV pathogenesis by WNT5A/VEGFA and associated miRNAs.

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Section: Discussionmentioning

confidence: 99%

In silico study identifies hub genes and regulatory network associated with the pathogenesis of Japanese Encephalitis Virus

Kumar

Chand

Azad

2023

Preprint

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“…[5][6][7] Accordingly, aberrations in PPIdependent processes can contribute to a diversity of pathologies related to cancer. 8,9 In this light, it is not surprising that targeting PPIs has emerged as an important area of discovery for anticancer therapeutic development. 2,10,11 In designing agents that target PPIs, a key consideration is that they must bind strongly enough to flat protein interfaces to overcome protein-protein interaction energies.…”

Section: Introductionmentioning

confidence: 99%

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

et al. 2021

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Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]

Cited by 2 publications

References 0 publications

In silico study identifies hub genes and regulatory network associated with the pathogenesis of Japanese Encephalitis Virus

In silico study identifies hub genes and regulatory network associated with the pathogenesis of Japanese Encephalitis Virus

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

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