Corrigendum to “Rejoining of cut wounds by engineered gelatin-keratin glue” [Biochim. Biophys. Acta, Gen. Subj. (2013) 4030–4039]

Raja, S.; Thiruselvi, T.; Sailakshmi, G.; Ganesh, S.; Gnanamani, A.

doi:10.1016/j.bbagen.2013.06.027

Cited by 3 publications

(4 citation statements)

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“…However, this material lost most adhesion ability if it was pre‐wetted, had no mechanism for tuneable or extended drug delivery, and lacked a biodegradable pathway. Other biodegradable adhesives exist, usually in the form of protein hydrogels, but their mechanical properties limits their application and they typically have low shear bioadhesion strengths of 50 mN cm −2 or less . A notable exception are the cyanoacrylate adhesives which displays strong adhesion force of 5000 mN cm −2 after initial compression of 5 N for 15 min and 4830 ± 1240 mN cm −2 on dry aorta tissues .…”

Section: Resultsmentioning

confidence: 99%

“…Other biodegradable adhesives exist, usually in the form of protein hydrogels, but their mechanical properties limits their application and they typically have low shear bioadhesion strengths of 50 mN cm À2 or less. [28,29] A notable exception are the cyanoacrylate adhesives which displays strong adhesion force of 5000 mN cm À2 after initial compression of 5 N for 15 min and 4830 AE 1240 mN cm À2 on dry aorta tissues [30,31] . Typical for cyanoacrylate glues, they have high adhesion forces but tend to be brittle.…”

Section: Comparison Of Bioadhesives Strengths On Wetted Soft Tissue Smentioning

confidence: 99%

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Novel On‐Demand Bioadhesion to Soft Tissue in Wet Environments

Mogal

Papper

Chaurasia

et al. 2013

Macromolecular Bioscience

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Current methods of tissue fixation rely on mechanical-related technologies developed from the clothing and carpentry industries. Herein, a novel bioadhesive method that allows tuneable adhesion and is also applicable to biodegradable polyester substrates is described. Diazirine is the key functional group that allows strong soft tissue crosslinking and on-demand adhesion based on a free radical mechanism. Plasma post-irradiation grafting makes it possible to graft diazirine onto PLGA substrates. When the diazirine-PLGA films, placed on wetted ex vivo swine aortas, are activated with low intensity UV light, lap shear strength of up to 450 ± 50 mN cm(-2) is observed, which is one order of magnitude higher than hydrogel bioadhesives placed on similar soft tissues. The diazirine-modified PLGA thin films could be added on top of previously developed technologies for minimally invasive surgeries. The present work is focused on the chemistry, grafting, and lap shear strength of the alkyl diazirine-modified PLGA bioadhesive films.

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Section: Resultsmentioning

confidence: 99%

Section: Comparison Of Bioadhesives Strengths On Wetted Soft Tissue Smentioning

confidence: 99%

Novel On‐Demand Bioadhesion to Soft Tissue in Wet Environments

Mogal

Papper

Chaurasia

et al. 2013

Macromolecular Bioscience

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“…This bioadhesive achieved maximum adhesion strength of 16.6 kPa in vitro and 1.67 MPa in vivo, respectively. [ 95 ] A silk‐based bioadhesive was developed using silk fibroin (SF) and tannic acid (TA), referring to TASK (Figure 4D). [ 92 ] The TASK powder was first prepared and then was transformed to a composite hydrogel by mixing with water.…”

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

Emerging Biopolymer‐Based Bioadhesives

Martinez

et al. 2021

Macromolecular Bioscience

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Bioadhesives have been widely used in healthcare and biomedical applications due to their ease‐of‐operation for wound closure and repair compared to conventional suturing and stapling. However, several challenges remain for developing ideal bioadhesives, such as unsatisfied mechanical properties, non‐tunable biodegradability, and limited biological functions. Considering these concerns, naturally derived biopolymers have been considered good candidates for making bioadhesives owing to their ready availability, facile modification, tunable mechanical properties, and desired biocompatibility and biodegradability. Over the past several years, remarkable progress has been made on biopolymer‐based adhesives, covering topics from novel materials designs and advanced processing to clinical translation. The developed bioadhesives have been applied for diverse applications, including tissue adhesion, hemostasis, antimicrobial, wound repair/tissue regeneration, and skin‐interfaced bioelectronics. Here in this comprehensive review, recent progress on biopolymer‐based bioadhesives is summarized with focuses on clinical translations and multifunctional bioadhesives. Furthermore, challenges and opportunities such as weak adhesion strength at the hydrated state, mechanical mismatch with tissues, and unfavorable immune responses are discussed with an aim to facilitate the future development of high‐performance biopolymer‐based bioadhesives.

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“…Moreover, the proteins with various functional groups such as –NH 2 , –SH, –COOH and –OH at the substrate interface exhibit some physical properties. 1 Therefore, modification of these varieties of functional groups makes proteins very important biomaterials for the production of hydrogels. Keratin is one of the fibrous proteins, 2 which contains leucine-aspartic acid-valine (LDV) motifs that interact with the cell surface to support cell adhesion and differentiation.…”

Section: Introductionmentioning

confidence: 99%