Corrigendum to “Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children” [Virology 378 (2008) 86–96]

Heo, Jun; Petheram, Susie; Demmler, Gail J.; Murph, Jody R.; Adler, Stuart P.; Bale, James F.; Sparer, Tim E.

doi:10.1016/j.virol.2008.10.007

Virology

2009

DOI: 10.1016/j.virol.2008.10.007

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Corrigendum to “Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children” [Virology 378 (2008) 86–96]

Jun Heo

Susie Petheram

Gail J. Demmler

et al.

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Congenital Cytomegalovirus Infection: Molecular Mechanisms Mediating Viral Pathogenesis

Schleiss¹

2011

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Human cytomegalovirus (CMV) is responsible for approximately 40,000 congenital infections in the United States each year. Congenital CMV disease frequently produces serious neurodevelopmental disability, as well as vision impairment and sensorineural hearing loss. Development of a CMV vaccine is therefore considered to be a major public health priority. The mechanisms by which CMV injures the fetus are complex and likely include a combination of direct fetal injury induced by pathologic virally-encoded gene products, an inability of the maternal immune response to control infection, and the direct impact of infection on placental function. CMV encodes gene products that function, both at the RNA and the protein level, to interfere with many cellular processes. These include gene products that modify the cell cycle; interfere with apoptosis; induce an inflammatory response; mediate vascular injury; induce site-specific breakage of chromosomes; promote oncogenesis; dysregulate cellular proliferation; and facilitate evasion of host immune responses. This minireview summarizes current concepts regarding these aspects of the molecular virology of CMV and the potential pathogenic impact of viral gene expression on the developing fetus. Areas for potential development of novel therapeutic intervention are suggested for improving the outcome of this disabling congenital infection.

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Congenital Cytomegalovirus Infection: Molecular Mechanisms Mediating Viral Pathogenesis

Schleiss¹

2011

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Corrigendum to “Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children” [Virology 378 (2008) 86–96]

Cited by 1 publication

References 0 publications

Congenital Cytomegalovirus Infection: Molecular Mechanisms Mediating Viral Pathogenesis

Congenital Cytomegalovirus Infection: Molecular Mechanisms Mediating Viral Pathogenesis

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