Corrigendum to “Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles” [Eur. J. Pharm. Biopharm. 116 (2017) 17–30]

Manjili, Hamidreza Kheiri; Ghasemi, Parisa; Malvandi, Hojjat; Mousavi, Mir Sajjad; Attari, Elahe; Danafar, Hossein

doi:10.1016/j.ejpb.2019.06.023

Cited by 6 publications

(17 citation statements)

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“…27,58,59 In this study, we demonstrate microfluidic shear processing control of the sizes, morphologies, loading, and release of CUR-PNPs. Consistent with previous studies, 37,38,45,47,53 we show that conventional nanoprecipitation manufacturing leads to decreased loading efficiencies and increased CUR precipitation as the amount of CUR in a formulation increases. In contrast, microfluidic manufacturing leads to CUR loading efficiencies that increase with both loading ratio and flow rate, allowing CUR loading of up to DL = 30 % to be achieved in this study.…”

Section: Introductionsupporting

confidence: 92%

“…A similar absence of time dependence for CUR IC50 values against MCF-7 has been previously observed. 47 The present result is not particularly surprising, considering the function of CUR as a relatively weak and nonspecific cytotoxic agent acting simultaneously on multiple cellular processes on a wide range of time scales.…”

mentioning

confidence: 52%

“…33,35,36 In response to these challenges, numerous researchers have investigated CUR encapsulation in the hydrophobic cores of block copolymer PNPs. [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] These studies have shown that CUR encapsulation promotes improved aqueous dispersion, increased chemical stability, and more sustained release compared to free CUR. In vivo studies have additionally shown that CURloaded PNPs (CUR-PNPs) show enhanced bioavailability, improved distribution in the body, and promising antitumor activity compared to the unencapsulated drug.…”

Section: Introductionmentioning

confidence: 99%

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Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles

2018

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We apply gas-liquid microfluidic reactors containing flow-variable, high-shear "hot spots" to produce curcumin-loaded polymer nanoparticles (CUR-PNPs) comprised of poly(caprolactone)- block-poly(ethylene oxide) (PCL- b-PEO) block copolymers at various flow rates and CUR loading ratios. CUR-PNPs prepared using the conventional nanoprecipitation method (bulk method) showed decreased encapsulation efficiency and increased drug precipitation as the loading ratio increased. However, CUR-PNPs prepared by microfluidic manufacturing showed both increased encapsulation efficiency and increased drug loading as either the flow rate or the loading ratio increased. This enabled microfluidic CUR loading percentages of up to 30% to be achieved in this study, which to our knowledge is a record for block copolymer PNPs. As well, it is shown that increased flow rate of microfluidic manufacturing leads to decreased mean CUR-PNP sizes (down to ∼50 nm) and narrower size distributions, along with significantly different CUR release kinetics compared to CUR-PNPs prepared at slower flow rates. In vitro antiproliferation experiments against MDA-MB-231 cells give an average IC value of 24 μM for CUR-PNPs compared to 13 μM for free CUR at the same incubation time of 72 h. Compared to conventional bulk and single-phase microfluidic strategies, this unique two-phase reactor represents an exciting manufacturing platform for optimizing polymeric CUR nanomedicines though flow-directed shear processing.

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Section: Introductionsupporting

confidence: 92%

mentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles

2018

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“…The amphiphilic nanoparticles are great nominees for loading the hydrophobic drugs [22]. PCL-PEG-PCL micelles are a tri-block PCL-PEG-PCL copolymer were self-assembled into nanoparticles with core-shell structure: a hydrophobic PCL core and a hydrophilic PEG shell [23][24][25]. An addition, PCL-PEG-PCL copolymers, setup with hydrophobic drugs, possibly will increase systemic distribution and fidelity of drugs and it can release drugs in a sustained time for the finest range of drug concentration [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo delivery of artemisinin loaded PCL–PEG–PCL micelles and its pharmacokinetic study

Manjili

Malvandi

Mousavi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Artemisinin (ART) is a natural anti-malarial sesquiterpene lactone with anticancer properties, but its application is limited because of its low water solubility. To increase the bioavailability and water solubility of ART, we synthesized three series of poly (ɛ-caprolactone)-poly (ethylene glycol)-poly (ɛ-caprolactone) (PCL-PEG-PCL) tri-block copolymers. The structure of the copolymers was characterized by HNMR, FTIR, DSC and GPC techniques. ART was encapsulated inside micelles by a nanoprecipitation method which leading to the formation of ART/PCL-PEG-PCL micelles. The obtained micelles were characterized by DLS and AFM technique. The results showed that the average size of micelles was about 83.22 nm. ART was encapsulated into PCL-PEG-PCL micelles with encapsulation efficacy of 89.23 ± 1.41%. In vivo results demonstrated that this formulation significantly increased drug accumulation in tumours. Pharmacokinetic study in rats revealed that in vivo drug exposure of ART was significantly increased and prolonged by intravenously administering ART-loaded micelles when compared with the same dose of free ART. The MTT assay showed that bare PCL-PEG-PCL micelles is non-toxic to MCF7 and 4T1 cancer cell lines whereas the ART/PCL-PEG-PCL micelles showed a specific toxicity to both cancer cell lines. Therefore, the polymeric micellar formulation of ART based copolymer could provide a desirable process for ART delivery.

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“…The biodegradable properties of PCL are highly desired in drug delivery systems, but its hydrophobicity requires a combination with another polymer to form micellar carriers with a proper hydrophobic/hydrophilic balance. For example, delivery of anti-cancer (paclitaxel, curcumin, sulforaphane, doxorubicin) and anti-inflammatory drugs by amphiphilic copolymers based mostly on PCL/poly(ethylene glycol) (PEG) with linear topology [23][24][25], PCL/poly(acrylic acid) [26,27] or PCL/dextran [28], as well as fibers [29,30] and microspheres formed by poly(vinyl alcohol)/PCL [31] or polydimethylsiloxane/PCL [32], have been reported. PCL has also found application in gene delivery [33,34] and tissue engineering (scaffolds) [35].…”

Section: Introductionmentioning

confidence: 99%

Micellar Carriers Based on Amphiphilic PEG/PCL Graft Copolymers for Delivery of Active Substances

Odrobińska

Neugebauer

2020

Polymers

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Amphiphilic copolymers of alkyne functionalized 2-hydroxyethyl methacrylate (AlHEMA) and poly(ethylene glycol) methyl ether methacrylate (MPEGMA) with graft or V-shaped graft topologies were synthesized. The functionalization of poly(ε-caprolactone) (PCL) with azide group enabled attachment to P(AlHEMA-co-MPEGMA) copolymers via a “click” alkyne-azide reaction. The introduction of PCL as a second side chain type in addition to PEG resulted in heterografted copolymers with modified properties such as biodegradability. “Click” reactions were carried out with efficiencies between 17–70% or 32–50% (for lower molecular weight PCL, 4000 g/mol, or higher molecular weight PCL, 9000 g/mol, respectively) depending on the PEG grafting density. The graft copolymers were self-assembled into micellar superstructures with the ability to encapsulate active substances, such as vitamin C (VitC), arbutin (ARB) or 4-n-butylresorcinol (4nBRE). Drug loading contents (DLC) were obtained in the range of 5–55% (VitC), 39–91% (ARB) and 42–98% (4nBRE). In vitro studies carried out in a phosphate buffer saline (PBS) solution (at pH 7.4 or 5.5) gave the maximum release levels of active substances after 10–240 min depending on the polymer system. Permeation tests in Franz chambers indicated that the bioactive substances after release by micellar systems penetrated through the artificial skin membrane in small amounts, and a majority of the bioactive substances remained inside the membrane, which is satisfactory for most cosmetic applications.

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Corrigendum to “Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles” [Eur. J. Pharm. Biopharm. 116 (2017) 17–30]

Cited by 6 publications

References 0 publications

Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles

Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles

In vitro and in vivo delivery of artemisinin loaded PCL–PEG–PCL micelles and its pharmacokinetic study

Micellar Carriers Based on Amphiphilic PEG/PCL Graft Copolymers for Delivery of Active Substances

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