Corrigendum to ‘Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy’ [International Journal of Antimicrobial Agents 51/1 (2018) 16-25]

Saeed, Kordo; Gould, Ian M.; Esposito, Silvano; Ahmad-Saeed, Nusreen; Ahmed, Salman; Alp, Emine; Bal, Abhijit M.; Bassetti, Matteo; Bonnet, É.; Chan, Mónica; Coombs, Geoffrey W.; Dancer, S.J.; David, Michael Z.; Simone, Giuseppe De; Dryden, Matthew; Guardabassi, Luca; Hanitsch, Leif G.; Hijazi, Karolin; Krüger, Renate; Lee, A.; Leistner, Rasmus; Pagliano, Pasquale; Righi, Elda; Schneider‐Burrus, Sylke; Skov, Robert; Tattevin, Pierre; vanWamel, W.J.B.; Vos, Margreet C.; Voß, Andreas

doi:10.1016/j.ijantimicag.2018.03.005

Cited by 6 publications

(3 citation statements)

References 78 publications

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“…The main protease (Mpro) enzyme of SARS-CoV-2 is the one that helps in the conversion of its polypeptides into functional proteins and is responsible for its transcription and replication as well [ 18 ]. Accordingly, targeting the Mpro of SARS-CoV-2 appears to be very promising for the management of the COVID-19 pandemic [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

et al. 2021

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In response to the urgent need to control Coronavirus disease 19 (COVID-19), this study aims to explore potential anti-SARS-CoV-2 agents from natural sources. Moreover, cytokine immunological responses to the viral infection could lead to acute respiratory distress which is considered a critical and life-threatening complication associated with the infection. Therefore, the anti-viral and anti-inflammatory agents can be key to the management of patients with COVID-19. Four bioactive compounds, namely ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were isolated from the leaves of Pimenta dioica (L.) Merr (ethyl acetate extract) and identified using spectroscopic evidence. Furthermore, molecular docking and dynamics simulations were performed for the isolated and identified compounds (1–4) against SARS-CoV-2 main protease (Mpro) as a proposed mechanism of action. Furthermore, all compounds were tested for their half-maximal cytotoxicity (CC50) and SARS-CoV-2 inhibitory concentrations (IC50). Additionally, lung toxicity was induced in rats by mercuric chloride and the effects of treatment with P. dioca aqueous extract, ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were recorded through measuring TNF-α, IL-1β, IL-2, IL-10, G-CSF, and genetic expression of miRNA 21-3P and miRNA-155 levels to assess their anti-inflammatory effects essential for COVID-19 patients. Interestingly, rutin 2, gallic acid 3, and chlorogenic acid 4 showed remarkable anti-SARS-CoV-2 activities with IC50 values of 31 µg/mL, 108 μg/mL, and 360 µg/mL, respectively. Moreover, the anti-inflammatory effects were found to be better in ferulic acid 1 and rutin 2 treatments. Our results could be promising for more advanced preclinical and clinical studies especially on rutin 2 either alone or in combination with other isolates for COVID-19 management.

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Section: Introductionmentioning

confidence: 99%

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

et al. 2021

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“…Furthermore, associations between phage activity and pathogenicity have been observed [8]. Numerous S. aureus prophages have been identified to date and analysis of their sequences has found genes encoding for Panton-Valentine leukocidin (PVL), exfoliative toxin A (eta), and the immune evasion cluster (IEC), which includes the enterotoxin S (sea), staphylokinase (sak), the chemotaxis inhibitory protein (chp), and the staphylococcal complement inhibitor (scn) [9][10][11][12][13][14]. This is in addition to several other virulence factors and genes conferring antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Examination of Staphylococcus aureus Prophages Circulating in Egypt

Ene

Miller-Ensminger

et al. 2021

Viruses

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Staphylococcus aureus infections are of growing concern given the increased incidence of antibiotic resistant strains. Egypt, like several other countries, has seen alarming increases in methicillin-resistant S. aureus (MRSA) infections. This species can rapidly acquire genes associated with resistance, as well as virulence factors, through mobile genetic elements, including phages. Recently, we sequenced 56 S. aureus genomes from Alexandria Main University Hospital in Alexandria, Egypt, complementing 17 S. aureus genomes publicly available from other sites in Egypt. In the current study, we found that the majority (73.6%) of these strains contain intact prophages, including Biseptimaviruses, Phietaviruses, and Triaviruses. Further investigation of these prophages revealed evidence of horizontal exchange of the integrase for two of the prophages. These Egyptian S. aureus prophages are predicted to encode numerous virulence factors, including genes associated with immune evasion and toxins, including the Panton–Valentine leukocidin (PVL)-associated genes lukF-PV/lukS-PV. Thus, prophages are likely to be a major contributor to the virulence of S. aureus strains in circulation in Egypt.

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“…Therapeutisch eignen sich bei PVLP-SA-Infektion v. a. Clindamycin und Linezolid, da sie als Proteinsyntheseinhibito-ren auch die PVL-Produktion potenziell hemmen können. Die Gabe von β-Laktam-Antibiotika sollte hochdosiert und antibiogrammgerecht erfolgen [5]. Nach PLVPSA-Nachweis wurde auch in diesem Fall die Therapie mit Linezolid und Ceftriaxon begonnen.…”

Section: Befunde Und Erste Diagnostikunclassified

Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion

Sahm

Baier

Lang

et al. 2020

Med Klin Intensivmed Notfmed

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Corrigendum to ‘Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy’ [International Journal of Antimicrobial Agents 51/1 (2018) 16-25]

Cited by 6 publications

References 78 publications

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

Examination of Staphylococcus aureus Prophages Circulating in Egypt

Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion

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