Corrigendum to: “Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline”

doi:10.1210/clinem/dgab307

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“…We firmly believe that diagnostic imaging with advanced sonography techniques [ 9 , 20 ] for the investigation of thyroid disease has been a game-changer element that has broadened our view about the real disease pathogenesis. We propose that the examination procedure described by us in this manuscript can lead to a substantial improvement of clinical practice at times when multi-author practice recommendations have been dismantled [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The field of clinical practice and thyroid diseases has been shattered in 2021 by an unprecedented action taken by the Endocrine Society. On 26 February 2021, i.e., fourteen years after the publication by Abalovich, Amino, Barbour, Cobin, De Groot, Glinoer, Mandel, and Stagnaro-Green (PMID 17948378), the Journal of Clinical Endocrinology & Metabolism has retired the guideline [ 5 ]. The same happened to the 2012 update of the guideline [ 6 ] which was written by De Groot, Abalovich, Alexander, Amino, Barbour, Cobin, Eastman, Lazarus, Luton, Mandel, Mestman, Rovet, and Sullivan (PMID 22869843).…”

Section: Preamblementioning

confidence: 99%

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Practical Guidelines for Diagnosing and Treating Thyroid Disease Based on the WOMED Metabolic Model of Disease Focusing on Glycolysis and Coenzyme Q10 Deficiency—A Clinical Alternative to the 2021 Retired Clinical Practice Guidelines of the Endocrine Society

Moncayo¹,

Moncayo²

2022

Diagnostics

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This review aims to provide a functional, metabolic view of the pathogenesis of benign thyroid disease. Here, we summarize the features of our previous publications on the “WOMED model of benign thyroid disease”. As of 2021, the current state of art indicates that the basic alteration in benign thyroid disease is a metabolic switch to glycolysis, which can be recognized using 3D-power Doppler ultrasound. A specific perfusion pattern showing enlarged vessels can be found using this technology. This switch originates from an altered function of Complex I due to acquired coenzyme Q10 deficiency, which leads to a glycolytic state of metabolism together with increased angiogenesis. Implementing a combined supplementation strategy that includes magnesium, selenium, and CoQ10, the morphological and perfusion changes of the thyroid can be reverted, i.e., the metabolic state returns to oxidative phosphorylation. Normalization of iron levels when ferritin is lower than 50 ng/mL is also imperative. We propose that a modern investigation of probable thyroid disease requires the use of 3D-power Doppler sonography to recognize the true metabolic situation of the gland. Blood levels of magnesium, selenium, CoQ10, and ferritin should be monitored. Thyroid function tests are complementary so that hypo- or hyperthyroidism can be recognized. Single TSH determinations do not reflect the glycolytic state.

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Section: Discussionmentioning

confidence: 99%

Section: Preamblementioning

confidence: 99%