Corrigendum to “Immunogenic gangliosides in human ovarian carcinoma” [Biochem. Biophys. Res. Commun. 353 (2007) 251–258]

Combination of automated solid-phase and enzymatic oligosaccharide synthesis provides access to α(2,3)-sialylated glycans

“…22 To evaluate the influence of the nearest neighbor of galactose on the enzymatic reactions, different sugars and linkages next to the galactose residue were explored. The target molecules are either tumor-associated carbohydrate antigens (TACAs) (1, 2, 4), 7,[23][24][25] associated with autoimmune disorders (1, 2, 4, 5), 10,[26][27][28] or exploited by pathogens (1, 4). 13,29,30 The synthetic strategy, exemplified for the synthesis of GM 1 b (2) (Scheme 1) relies on the automated solid phase assembly of the glycan backbone (11) using thioglycoside building blocks (6)(7)(8)(9) and resin appended with a photo-cleavable linker (10) 31 through successive cycles of glycosylation.…”