Corrigendum to Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition [Acta Biomaterialia, Volume 161, 15 April 2023, Pages 285-297]

Design, fabrication and clinical characterization of additively manufactured tantalum hip joint prosthesis

“…conducted in vivo and in vitro experiments to compare the inflammatory response of pure titanium, Ti6Al4V, PEEK and 316 L stainless steel. Their findings also confirm that the chemical composition of materials plays a significant role in immune cell response [ 35 ].…”

“…Derek Avery et al . found that the chemical composition of the biomaterials [ 35 ] largely drives the inflammatory response. In vitro macrophage studies showed that SLM Ta could regulate the inflammatory microenvironment and reduce the inflammatory response caused by the implant.…”

Visible particles in parenteral drug products: A review of current safety assessment practice

“…The chemical composition of a particle can be important in impacting product quality and patient safety. Depending on the type of particles, chemical constituents may leach from the particles and cause adverse effects ( Bukofzer et al, 2015 , Heddagaard and Møller, 2020 , Avery et al, 2023 ). These leachates are regarded as impurities which may result in direct chemical hazard-related effects and may also indirectly alter the physiochemical properties of DPs via interaction with the active pharmaceutical ingredient or the excipients in product formulation.…”

“…On the other hand, larger particles than 10 µm are expected to be destroyed by macrophages potentially resulting in formation of granuloma ( Pagán and Ramakrishnan, 2018 ). A well-known example is the age-old medical challenge related to biomedical implants which stimulate foreign body reactions ( Avery et al, 2023 ). Similar to other physiological protective mechanisms, granuloma can also be pathological.…”

“…The nature and chemical composition of particles is a very important aspect for particle safety assessment and risk management ( Barba, 2000 , Bukofzer et al, 2015 , Alijagic et al, 2022 , Avery et al, 2023 ). If the constituents in particles leach out, chemical exposure ensues potentially resulting in chemical toxicity depending on the hazard profile of the leachates.…”