Corrigendum to “Generation of Leydig-like cells: approaches, characterization, and challenges”

Li, Zhaohui; Lu, Jun-Dong; Li, Shijun; Chen, Haolin; Su, Zhijian

doi:10.4103/aja202323

Cited by 1 publication

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“…In humans and rodents, the substrate cholesterol is transferred into the mitochondrial inner membrane by steroidogenic acute regulatory protein (StAR) and converted into pregnenolone by the cholesterol side-chain cleavage cytochrome P450 enzyme (CYP11A1). Pregnenolone is then converted to testosterone by 3βhydroxysteroid dehydrogenase (HSD3B), cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) and type 3/5 17βhydroxysteroid dehydrogenase (HSD17B3/5) in the smooth endoplasmic reticulum (Li et al, 2022). Steroid 5α-reductases, including SRD5A1 and SRD5A2, are able to further convert testosterone into DHT.…”

Section: Discussionmentioning

confidence: 99%

Integrated multi-omics analysis reveals insights into Chinese forest musk deer (Moschus berezovskii) genome evolution and musk synthesis

Hong

Feng

et al. 2023

Front. Cell Dev. Biol.

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Among the artiodactyls, male animals belonging to the Family Moschidae have a unique tissue, the musk gland, with the capability of musk synthesis. However, the genetic basis of musk gland formation and musk production are still poorly understood. Here, musk gland tissues from two juvenile and three adult Chinese forest musk deer (Moschus berezovskii) were utilized to analyze genomic evolution events, evaluate mRNA profiles and investigate cell compositions. By performing genome reannotation and comparison with 11 ruminant genomes, three expanded gene families were identified in the Moschus berezovskii genome. Transcriptional analysis further indicated that the musk gland displayed a prostate-like mRNA expression pattern. Single-cell sequencing revealed that the musk gland is composed of seven distinguishable cell types. Among them, sebaceous gland cells and luminal epithelial cells play important roles in musk synthesis, while endothelial cells master the regulation of cell-to-cell communication. In conclusion, our study provides insights into musk gland formation and the musk-synthesizing process.

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Section: Discussionmentioning

confidence: 99%