Corrigendum to “Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria” [Bioorg. Med. Chem. 26(17) (2018) 4942–4951]

Metal and Ligand‐Free Approach Towards the Efficient One‐Pot Synthesis of Dipyridopyrimidinimine Derivatives

“…reported a facile metal‐free one‐pot synthesis strategy for the construction of a series of biologically active compounds. This approach utilized readily available 2‐fluorobenzonitrile and 2‐aminopyridine as starting materials in the presence of KO t Bu as a base and DMSO as a solvent (Scheme 1, Path 1) [6] . In another approach from 2015, Feng, Wu and coworkers developed an SNAr reaction followed by an intramolecular rearrangement procedure using KO t Bu as a promoter, enabling the convenient synthesis of quinazolinimines through the reaction between 2‐fluorobenzonitrile and 2‐aminopyridine (Scheme 1, Path 2) [7] .…”

Microwave-assisted annulation for the construction of pyrido-fused heterocycles and their application as photoluminescent chemosensors

“…1 Among the various fused quinazolinones, pyrido-fused quinazolinone derivatives play an imperative role in drug development and exhibit potent pharmacological activities such as anti-allergy, 2 anti-cancer, 3 anti-oxidant, 4 and anti-bacterial properties, 5 in addition to acting as efflux pump inhibitors. 6 Similarly, pyrido[1,2-a]benzimidazole derivatives have gained increasing attention in the areas of heterocyclic and medicinal chemistry because of their occurrence in natural alkaloids and their diverse biological activities, including anti-oxidant 7 anti-viral, 8 anti-malarial, 9 anti-schistosomal, 10 anti-microbial, 11 anti-HIV-1, 12 perforin-inhibition, 13 and anti-cancer 14 properties. Selected examples of natural and pharmaceutically important pyrido-fused quinazolinones and pyrido [1,2-a]benzimidazoles are shown in Fig.…”