Corrigendum to “Diagnostic delay of endometriosis in adults and adolescence-current stage of knowledge” [Adv. Med. Sci. (2022 Mar) 67 (1) 148-153]

Wróbel, Monika; Wielgoś, Mirosław; Laudański, Piotr

doi:10.1016/j.advms.2022.12.004

Cited by 2 publications

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“…This chronic inflammatory condition is classified as benign; however, it involves malignant behavior of invasion and migration [ 1 , 2 ]. Endometriosis is estimated to affect 10% of women of reproductive age [ 3 ]. It manifests in a variety of nonspecific symptoms, including gynecological (dysmenorrhea, pelvic pain, dyspareunia), digestive (diarrhea and/or constipation, pain on bowel movement, intestinal cramping, pain on defecation, cyclic rectal bleeding), lower back pain and asthenia [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…It manifests in a variety of nonspecific symptoms, including gynecological (dysmenorrhea, pelvic pain, dyspareunia), digestive (diarrhea and/or constipation, pain on bowel movement, intestinal cramping, pain on defecation, cyclic rectal bleeding), lower back pain and asthenia [ 4 ]. Diagnosis can be challenging and a large diagnostic still exists, delay reaching up to 7.4 years [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Wróbel,

Zuzanna,

Ołdak

et al. 2023

IJMS

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Endometriosis is a chronic disease in which the endometrium cells are located outside the uterine cavity. The aim of this study was to evaluate circulating 20S proteasome and 20S immunoproteasome levels in plasma and peritoneal fluid in women with and without endometriosis in order to assess their usefulness as biomarkers of disease. Concentrations were measured using surface plasmon resonance imaging biosensors. Patients with suspected endometriosis were included in the study—plasma was collected in 112 cases and peritoneal fluid in 75. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group (confirmed endometriosis) and a control group (patients without endometriosis). Proteasome and immunoproteasome levels in both the plasma (p = 0.174; p = 0.696, respectively) and the peritoneal fluid (p = 0.909; p = 0.284, respectively) did not differ between those groups. There was a statistically significant difference in the plasma proteasome levels between patients in the control group and those with mild (Stage I and II) endometriosis (p = 0.047) and in the plasma immunoproteasome levels in patients with ovarian cysts compared to those without (p = 0.017). The results of our study do not support the relevance of proteasome and immunoproteasome determination as biomarkers of the disease but suggest a potentially active role in the pathogenesis of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Wróbel,

Zuzanna,

Ołdak

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

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Features of endometriosis in adolescent girls: difficulties in diagnosis and prevention of complications

Adamyan,

Sibirskaya,

Sharkov

et al. 2024

RPJ

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Introduction. Endometriosis is an estrogen–dependent disease characterized by the spread of endometrial-like tissue outside the uterine cavity. Symptoms of the disease appear after menarche, in adolescence. The symptoms of endometriosis often go unnoticed and underestimated in early age, which leads to a delay in the beginning of therapy and the progression of the disease. The difficulty of diagnosing of endometriosis in adolescents is determined not only by the specificity of the clinical picture, but also by the lack of generally accepted markers for detecting the disease, as well as the difficulty of identifying initial forms using imaging techniques such as ultrasound, MRI. The purpose of this review is to identify the age-related features of endometriosis, especially in children and adolescents, to provide early diagnosis of the disease and timely initiation of the treatmen. Endometrial foci in adolescents look different from adults. As a rule, merging vesicular or papular, transparent, red and white lesions are more characteristic than black or blue ones for this age group. While in adult women, the foci of endometriosis are black with pronounced fibrosis. Histological examination after laparoscopic surgery remains the gold standard for confirming the diagnosis, although the results of these studies may not always correspond to each other. Microscopic examination reveals areas of fibrous, fatty, muscular tissue, hemorrhages, vessels, areas of calcification and infiltration by multinucleated leukocytes, as well as a combination of endosalpingiosis and endometriod-like tissues. Moreover, it is important to carry out differential diagnosis with chronic pelvic pain, as well as with abnormalities in development, pathologies of the gastrointestinal tract, adenomyosis. Conclusion. Thus, endometriosis is an estrogen-dependent disease affecting more than 10% of women of reproductive age. However, often the symptoms of the disease go unnoticed in adolescence, which leads to the progression of the disease in the future in women. Timely diagnosis of endometriosis plays an important role in preventing the development of complications and eliminating infertility in the future.

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Corrigendum to “Diagnostic delay of endometriosis in adults and adolescence-current stage of knowledge” [Adv. Med. Sci. (2022 Mar) 67 (1) 148-153]

Cited by 2 publications

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Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Features of endometriosis in adolescent girls: difficulties in diagnosis and prevention of complications

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