Corrigendum to “Deep brain stimulation of the internal pallidum in multiple system atrophy”

Santens, Patrick; Vonck, Kristl; Letter, Miet De; Driessche, K. Van; Sieben, Anne; Reuck, Jacques De; Roost, Dirk Van; Boon, Paul

doi:10.1016/j.parkreldis.2006.08.002

Cited by 6 publications

(6 citation statements)

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“…Moreover, more than one quarter of patients died within 7 months of surgery. Owing to the limited number of reports, the poor outcome, and the possibility of a harmful effect, DBS is currently not recommended in MSA …”

Section: Symptomatic Therapiesmentioning

confidence: 99%

Current Concepts in the Treatment of Multiple System Atrophy

Pérez-Lloret

Flabeau

Fernagut

et al. 2015

Movement Disord Clin Pract

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MSA is a progressive neurodegenerative disorder characterized by autonomic failure and a variable combination of poor levodopa‐responsive parkinsonism and cerebellar ataxia (CA). Current therapeutic management is based on symptomatic treatment. Almost one third of MSA patients may benefit from l‐dopa for the symptomatic treatment of parkinsonism, whereas physiotherapy remains the best therapeutic option for CA. Only midodrine and droxidopa were found to be efficient for neurogenic hypotension in double‐blind, controlled studies, whereas other symptoms of autonomic failure may be managed with off‐label treatments. To date, no curative treatment is available for MSA. Recent results of neuroprotective and ‐restorative trials have provided some hope for future advances. Considerations for future clinical trials are also discussed in this review.

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Section: Symptomatic Therapiesmentioning

confidence: 99%

Current Concepts in the Treatment of Multiple System Atrophy

Pérez-Lloret

Flabeau

Fernagut

et al. 2015

Movement Disord Clin Pract

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“…46 However, other authors have reported deleterious effects of deep brain stimulation. [46][47][48][49][50][51][52] At present, surgical therapy is not considered an effective therapeutic tool in the routine management of patients with MSA.…”

Section: Therapymentioning

confidence: 99%

Tremor in Multiple System Atrophy – a review

Kaindlstorfer

Granata

Wenning

2013

Tremor and Other Hyperkinetic Movements

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Background: Multiple system atrophy (MSA) is a rare neurodegenerative movement disorder characterized by a rapidly progressive course. The clinical presentation can include autonomic failure, parkinsonism, and cerebellar signs. Differentiation from Parkinson's disease (PD) is difficult if there is levodoparesponsive parkinsonism, rest tremor, lack of cerebellar ataxia, or mild/delayed autonomic failure. Little is known about tremor prevalence and features in MSA. Methods: We performed a PubMed search to collect the literature on tremor in MSA and considered reports published between 1900 and 2013. Results: Tremor is a common feature among MSA patients. Up to 80% of MSA patients show tremor, and patients with the parkinsonian variant of MSA are more commonly affected. Postural tremor has been documented in about half of the MSA population and is frequently referred to as jerky postural tremor with evidence of minipolymyoclonus on neurophysiological examination. Resting tremor has been reported in about one-third of patients but, in contrast to PD, only 10% show typical parkinsonian ''pill-rolling'' rest tremor. Some patients exhibit intention tremor associated with cerebellar dysmetria. In general, MSA patients can have more than one tremor type owing to a complex neuropathology that includes both the basal ganglia and pontocerebellar circuits. Discussion: Tremor is not rare in MSA and might be underrecognized. Rest, postural, action and intention tremor can all be present, with jerky tremulous movements of the outstretched hands being the most characteristic. However, reviewing the data on tremor in MSA suggests that not every shaky movement satisfies tremor criteria; therefore, further studies are needed.

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“…Moreover, more than a quarter of patients died within 7 months of surgery. Owing to the limited number of reports, the poor outcome and the possibility of a harmful effect, DBS is currently not recommended in MSA [Wenning and Stefanova, 2009;Lambrecq et al 2008;Shih and Tarsy, 2007;Santens et al 2006;Talmant et al 2006;Tarsy et al 2003].…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Multiple system atrophy: current and future approaches to management

Flabeau

Meissner

Tison

2010

Ther Adv Neurol Disord

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Multiple system atrophy (MSA) is a rare neurodegenerative disorder without any effective treatment in slowing or stopping disease progression. It is characterized by poor levodopa responsive Parkinsonism, cerebellar ataxia, pyramidal signs and autonomic failure in any combination. Current therapeutic strategies are primarily based on dopamine replacement and improvement of autonomic failure. However, symptomatic management remains disappointing and no curative treatment is yet available. Recent experimental evidence has confirmed the key role of alpha-synuclein aggregation in the pathogenesis of MSA. Referring to this hypothesis, transgenic and toxic animal models have been developed to assess candidate drugs for MSA. The standardization of diagnosis criteria and assessment procedures will allow large multicentre clinical trials to be conducted. In this article we review the available symptomatic treatment, recent results of studies investigating potential neuroprotective drugs, and future approaches for the management in MSA.

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Corrigendum to “Deep brain stimulation of the internal pallidum in multiple system atrophy”

Cited by 6 publications

References 0 publications

Current Concepts in the Treatment of Multiple System Atrophy

Current Concepts in the Treatment of Multiple System Atrophy

Tremor in Multiple System Atrophy – a review

Multiple system atrophy: current and future approaches to management

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