Corrigendum to ‘Cavitation emissions nucleated by Definity infused through an EkoSonic catheter in a flow phantom’ [Ultrasound in Med &amp; Biol. 47 (2021) 693-709]

Escudero, Daniel Suarez; Lafond, Maxime; Salido, Nuria González; Haworth, Kevin J.; Hannah, Andrew; Macke, Gregory P.; Genstler, Curtis; Holland, Christy K.

doi:10.1016/j.ultrasmedbio.2022.09.012

Cited by 2 publications

(9 citation statements)

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“…Attenuation of the OFP-PAFb-PGN-ELIP decreased after infusion through the EkoSonic catheter (Fig. 2 b), which is consistent with the loss of Definity attenuation after infusion through the same catheter 22 , 23 . OFP-PAFb-PGN-ELIP agglomeration was observed after dilution and infusion, but only after several hours.…”

Section: Discussionsupporting

confidence: 74%

“…We hypothesize retention is either due to material interaction or to a size discrepancy between the OFP-PAFb-PGN-ELIP and the delivery holes of the catheter, which are 38 to 46 µm in diameter. Lafond et al 22 , 23 found that infusion rate impacted the size distribution of Definity infusing through the EkoSonic catheter. Talu et al 31 reported that lipid-encapsulated and perfluorocarbon-filled microbubbles were sensitive to orifice size and infusion rate.…”

Section: Discussionmentioning

confidence: 99%

“…Acoustic emissions were recorded every 1.0 ± 0.2 s (mean ± s.d.). Acoustic emission spectra, including inharmonics, subharmonics, and ultraharmonics were independently beamformed 22 , 23 on a personal computer (Dell Precision 5820, Round Rock, TX, USA) using custom MATLAB code (R2018b). Cavitation data from saline infusions served as a baseline and were subtracted from the Definity and OFP-PAFb-PGN-ELIP cavitation data.…”

Section: Methodsmentioning

confidence: 99%

“…PCI beamforming, cavitation energy calculations, and composite image formulations were adapted from Lafond et al 22 with corrections in the beamforming algorithm and code 23 . Data acquisition commenced immediately after the EkoSonic transducer pairs were triggered.…”

Section: Methodsmentioning

confidence: 99%

“…Lafond et al demonstrated that Definity infused through the EkoSonic catheter could be used to nucleate sustained cavitation over 3 min. 22 , 23 Due to the nucleation of inertial and stable cavitation from infused contrast agents and the potential for deleterious tissue side effects, the FDA requires careful characterization of the cavitation spawned by OFP-PAFb-PGN-ELIP infused through and insonified by the EkoSonic catheter before clinical trials can commence.…”

Section: Introductionmentioning

confidence: 99%

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Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter

Kennedy

Lafond

Haworth

et al. 2023

Sci Rep

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Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through an EkoSonic catheter. Cavitation activity was nucleated by Definity or fibrin-targeted, drug-loaded echogenic liposomes infused and insonified with EkoSonic catheters. Passive cavitation imaging was used to quantify and map bubble activity in a flow phantom mimicking porcine arterial flow. Cavitation was sustained during 3-min infusions of Definity or echogenic liposomes along the distal 6 cm treatment zone of the catheter. Though the EkoSonic catheter was not designed specifically for cavitation nucleation, infusion of drug-loaded echogenic liposomes can be employed to trigger and sustain bubble activity for enhanced intravascular drug delivery.

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Section: Discussionsupporting

confidence: 74%