Corrigendum to “Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds” [Polym. Test. 76 (2019) 464–472]

Zvicer, Jovana; Medic, Ana; Veljović, Djordje; Jevtić, Sanja; Novak, Saša; Obradović, Bojana

doi:10.1016/j.polymertesting.2019.105908

Cited by 2 publications

(3 citation statements)

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“…Presumably, for these types of scaffolds, the current dependence will also reach a level at which the rates of diffusion of nutrients through the scaffold will not be determined by their rotation rates. At the same time, the results obtained within the scaffolds of the presented model of composite biological scaffolds with 10% of HAP content and the studied pore architecture, are consistent with experimental observations of bone tissue growth in three-dimensional scaffolds [21,[43][44][45] which present a quantitative assessment of the rate of diffusion flow of nutrients at culturing cells (in vitro) with high density. Although the model has some assumptions, studies have shown that physical parameters such as total pore volume and pore diameter have a significant impact on the internal perfusion of nutrients.…”

Section: Results Of Internal Flow Modelingsupporting

confidence: 87%

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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Tissue engineering (TE) is one of the promising areas that aims to address the global problem of organ and tissue shortages. The successful development of TE, particularly in bone tissue engineering, consists of the use of modern methods that allow the creation of scaffolds, the physicochemical, mechanical, and structural parameters of which will allow achieving the desired clinical results. The vast possibilities of the rapidly developing technology of three-dimensional (3D) printing, which allows the creation of individual scaffolds with high precision, has led to various developments in bone tissue TE. In this work, for the successful use of three-dimensional printing in TE to ensure the diffusion of nutrients during cell cultivation throughout the entire structure of the scaffold, a model of a rotating scaffold is proposed, and the movement of the diffusion flow of nutrient fluid is calculated based on Darcy’s law, which regulates the flow of fluids through porous media. The conducted studies of the rate of diffusion flow of nutrients based on glucose in the porous structure of scaffolds with a 10% content of calcium hydroxyapatite demonstrated the promise of using a model of a rotating composite scaffold in TE of bone tissue. The results show that at a scaffold rotation speed of 12 rpm, the diffusion flow rate of nutrients in the composite scaffolds porous structure is practically not affected by their geometric shape.

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Section: Results Of Internal Flow Modelingsupporting

confidence: 87%

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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“…[ 64 ] To further improve the mineral distribution through large scaffolds, perfusion of the mineralization solution needs to be explored. [ 65 ]…”

Section: Discussionmentioning

confidence: 99%

“…[64] To further improve the mineral distribution through large scaffolds, perfusion of the mineralization solution needs to be explored. [65] Other in vitro remodeling models have used synthetic (mineralized) polymers, organic matrices or inorganic materials in the form of hydrogels or woven scaffolds. [14] When composite materials are used for in vitro remodeling studies, organic materials are often mineralized by blending it with inorganic salts during fabrication or by coating it with supersaturated solutions.…”

Section: Discussionmentioning

confidence: 99%

Bioinspired Silk Fibroin Mineralization for Advanced In Vitro Bone Remodeling Models

Wildt

Bartels

Sommerdijk

et al. 2022

Adv Funct Materials

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Human in vitro bone models can create the possibility for investigation of physiological bone remodeling while addressing the principle of replacement, reduction and refinement of animal experiments (3R). Current in vitro models lack cell-matrix interactions and their spatiotemporal complexity. To facilitate these analyses, a bone-mimetic template is developed in this study, inspired by bone's extracellular matrix composition and organization. Silk fibroin (SF) is used as an organic matrix, poly-aspartic acid (pAsp) is used to mimic the functionality of noncollagenous proteins, and 10× simulated body fluid serves as mineralization solution. By using pAsp in the mineralization solution, minerals are guided toward the SF material resulting in mineralization inside and as a coating on top of the SF. After cytocompatibility testing, remodeling experiments are performed in which mineralized scaffold remodeling by osteoclasts and osteoblasts is tracked with nondestructive microcomputed tomography and medium analyses over a period of 42 d. The mineralized scaffolds support osteoclastic resorption and osteoblastic mineralization, in the physiological bone remodeling specific sequence. This model could therefore facilitate the investigation of cell-matrix interactions and may thus reduce animal experiments and advance in vitro drug testing for bone remodeling pathologies like osteoporosis, where cell-matrix interactions need to be targeted.

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Corrigendum to “Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds” [Polym. Test. 76 (2019) 464–472]

Cited by 2 publications

References 0 publications

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Bioinspired Silk Fibroin Mineralization for Advanced In Vitro Bone Remodeling Models

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