Corrigendum to “An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic therapy to enhance chondrogenesis” [Biomaterials 218 (2019) 119190]

Lu, Zhenhui; Liu, Sijia; Le, Yiguan; Qin, Zainen; He, Mingwei; Xu, Fuben; Zhu, Ye; Zhao, Jinmin; Mao, Chuanbin; Zheng, Li

doi:10.1016/j.biomaterials.2019.119662

Cited by 1 publication

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“…The physical limitations are related to the treatment of different fractures, which inevitably infer a surgical approach. In addition to naturally occurring fractures that have occurred because of different incidents, , the physical limitation to the use of nanoscale drug delivery systems also includes secondary bone tissue conditions , (those directly connected with surgical outcomes) and malunion types of fracture (abnormal healing of a broken bone). , Nevertheless, nanoscale-based formulations and platforms have already been studied postsurgically − to cope with some of these physical limitations. In rat models, researchers , have achieved promotion of hard tissue formation after a defect was induced, which marks a promising position of these systems to be applied to humans.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Stoilov,

Truong,

Gronthos

et al. 2023

ACS Appl. Bio Mater.

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Bone tissue plays a crucial role in protecting internal organs and providing structural support and locomotion of the body. Treatment of hard tissue defects and medical conditions due to physical injuries, genetic disorders, aging, metabolic syndromes, and infections is more often a complex and drawn out process. Presently, dealing with hard-tissue-based clinical problems is still mostly conducted via surgical interventions. However, advances in nanotechnology over the last decades have led to shifting trends in clinical practice toward noninvasive and microinvasive methods. In this review article, recent advances in the development of nanoscale platforms for bone tissue engineering have been reviewed and critically discussed to provide a comprehensive understanding of the advantages and disadvantages of noninvasive and microinvasive methods for treating medical conditions related to hard tissue regeneration and repair.

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