Corrigendum. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Koedooder, R.; Singer, M.; Schoenmakers, Sam; Savelkoul, Paul H. M.; Morré, Servaas A.; Jonge, J. D. de; Poort, Linda; Cuypers, W. J. S. S.; Beckers, Nicole G. M.; Broekmans, Frank J.; Cohlen, Ben J; Hartog, J.E. den; Fleischer, Kathrin; Lambalk, Cornelis B.; Smeenk, J.M.J.; Budding, Andries E.; Laven, Joop

doi:10.1093/humrep/dez127

Cited by 2 publications

(1 citation statement)

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“…This is in dramatic contrast to the more widely studied intestinal microbiota, where a loss of diversity is often observed at the onset or during disease, and a high bacterial diversity is key to maintenance of homeostasis 6 . The composition of the vaginal microbiota correlates with risk of infection of the reproductive and urinary tracts 5,[7][8][9][10] , fertility and pregnancy outcomes [11][12][13][14][15][16][17] , and potentially cancers and cancer treatment outcomes [18][19][20] . However, despite the tremendous importance of the vaginal microbiota, we currently lack effective strategies for correcting dysbiosis durably.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-free vaginal microbiota transplantation (VMT) changes vaginal microbiota and immune profile in women with asymptomatic dysbiosis – reporting of a randomized, placebo-controlled trial

Bosma,

Mortensen,

DeLong

et al. 2024

Preprint

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Here, we describe the first placebo-controlled trial of vaginal microbiota transplantation (VMT) in women with asymptomatic dysbiosis without the use of antibiotic pretreatment. Importantly, we also describe the implementation of a donor program and banking of donor cervicovaginal secretions (CVS) while retaining sample viability, which is crucial to allow for scale-up and confirmatory quality testing. By metagenome sequencing, we demonstrate that VMT provided a significant increase in combinedLactobacillusspecies in the active arm and strain-level genetic analysis confirmedLactobacillusengraftment. Moreover, VMT was well tolerated and showed a good safety profile. Furthermore, a shift toward increasedLactobacilluswas associated with a change in the expression profile of genes in the complement pathway to a more anti-inflammatory profile. Vaginal microbial and immune profile restoration using VMT may have a positive impact on a wide range of conditions in women’s health.

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Section: Introductionmentioning

confidence: 99%

Antibiotic-free vaginal microbiota transplantation (VMT) changes vaginal microbiota and immune profile in women with asymptomatic dysbiosis – reporting of a randomized, placebo-controlled trial

Bosma,

Mortensen,

DeLong

et al. 2024

Preprint

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Dominant <i>Lactobacillus</i> spp. in different conditions of vaginal microbiocenosis

Kalinina

Сулима

Rumyantseva

et al. 2022

Journal of obstetrics and women's diseases

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The vaginal microbiota is a primary non-specific barrier that protects against various bacterial, viral and fungal pathogens. A normal microflora of the female genital tract is represented by aerobes, facultative and strict anaerobes. Bacteria of the genus Lactobacillus spp. dominate the majority of women of reproductive age. They have high protective properties against other microorganisms. Lactobacillus spp. prevent an excessive reproduction of opportunistic and pathogenic microorganisms in the vaginal biotope due to the synthesis of short-chain acids that maintain the pH value in the normal range. As a rule, one or two species of Lactobacillus spp. dominate in the vaginal biotope, which are responsible for ensuring homeostasis of the vaginal microflora. At the same time, various Lactobacillus spp. differ in their protective properties. L. crispatus is a marker of the stability of the vaginal microflora. With the dominance of this type of lactobacillus, the authors of the studies observed a low risk of bacterial vaginosis, aerobic vaginitis, and unwanted obstetric complications during pregnancy and in assisted reproductive technology protocols, as well as a reduced risk of infection with sexually transmitted infections and human papillomavirus. L. gasseri and L. iners were more often detected in women with intermediate microflora or with dysbiosis. L. iners, unlike L. crispatus, has reduced protective properties and is widespread in dysbiotic conditions of the vaginal microflora. The detection of L. iners can serve as a prognostic sign of the development of pathological conditions of the vaginal microflora.

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Corrigendum. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Cited by 2 publications

References 0 publications

Antibiotic-free vaginal microbiota transplantation (VMT) changes vaginal microbiota and immune profile in women with asymptomatic dysbiosis – reporting of a randomized, placebo-controlled trial

Antibiotic-free vaginal microbiota transplantation (VMT) changes vaginal microbiota and immune profile in women with asymptomatic dysbiosis – reporting of a randomized, placebo-controlled trial

Dominant <i>Lactobacillus</i> spp. in different conditions of vaginal microbiocenosis

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