Corrigendum: The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus

Dong, Yuyan; Liu, Juxiang; Ma, Jing; Quan, Jinxing; Bao, Yungang; Cui, Yaqiang

doi:10.3389/fendo.2022.1046738

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(3) Direct Stimulation of Macrophage Inflammatory Response: TSH can reportedly activate the MAPK (ERK1/2, P38, JNK) and I kappa B/P65 pathways in macrophages. This activation results in enhanced production of inflammatory cytokines, including tumor necrosis factor (TNF)-α and Interleukin (IL)-6, thus promoting an inflammatory response within the body and encouraging monocyte recruitment ( 34 – 36 ). TSH also induces the generation of Reactive Oxygen Species (ROS), contributing to oxidative stress and apoptosis and ultimately facilitating the development of vulnerable plaques ( 16 , 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…Another study showed that serum TSH levels were positively correlated with cholesterol, even within the normal reference range, which also validated the influence of TSH on lipid metabolism ( 16). ( 2 (34)(35)(36). TSH also induces the generation of Reactive Oxygen Species (ROS), contributing to oxidative stress and apoptosis and ultimately facilitating the development of vulnerable plaques (16,17).…”

Section: The Pathological Mechanism Of Thr In Predicting Vulnerable C...mentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Lei,

Weng,

Wang

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectiveThis study aimed to investigate the predictive value of the thyroid-stimulating hormone to high-density lipoprotein cholesterol ratio (THR) in identifying specific vulnerable carotid artery plaques.MethodsIn this retrospective analysis, we included 76 patients with carotid plaques who met the criteria for admission to Zhejiang Hospital from July 2019 to June 2021. High-resolution magnetic resonance imaging (HRMRI) and the MRI-PlaqueView vascular plaque imaging diagnostic system were utilized to analyze carotid artery images for the identification of specific plaque components, including the lipid core (LC), fibrous cap (FC), and intraplaque hemorrhage (IPH), and recording of the area percentage of LC and IPH, as well as the thickness of FC. Patients were categorized into stable plaque and vulnerable plaque groups based on diagnostic criteria for vulnerable plaques derived from imaging. Plaques were categorized based on meeting one of the following consensus criteria for vulnerability: lipid core area over 40% of total plaque area, fibrous cap thickness less than 65 um, or the presence of intraplaque hemorrhage. Plaques meeting the above criteria were designated as the LC-associated vulnerable plaque group, the IPH-associated group, and the FC-associated group. Multivariate logistic regression was employed to analyze the factors influencing carotid vulnerable plaques and specific vulnerable plaque components. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serological indices for vulnerable carotid plaques.ResultsWe found that THR (OR = 1.976; 95% CI = 1.094–3.570; p = 0.024) and TSH (OR = 1.939, 95% CI = 1.122–3.350, p = 0.018) contributed to the formation of vulnerable carotid plaques. THR exhibited an area under the curve (AUC) of 0.704 (95% CI = 0.588–0.803) (p = 0.003), and the AUC for TSH was 0.681 (95% CI = 0.564–0.783) (p = 0.008). THR was identified as an independent predictor of LC-associated vulnerable plaques (OR = 2.117, 95% CI = 1.064–4.212, p = 0.033), yielding an AUC of 0.815. THR also demonstrated diagnostic efficacy for LC-associated vulnerable plaques.ConclusionThis study substantiated that THR and TSH have predictive value for identifying vulnerable carotid plaques, with THR proving to be a more effective diagnostic indicator than TSH. THR also exhibited predictive value and specificity in the context of LC-associated vulnerable plaques. These findings suggest that THR may be a promising clinical indicator, outperforming TSH in detecting specific vulnerable carotid plaques.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: The Pathological Mechanism Of Thr In Predicting Vulnerable C...mentioning

confidence: 99%

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Lei,

Weng,

Wang

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

Corrigendum: The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus

Abstract: A Corrigendum onThe possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus.

Cited by 1 publication

References 0 publications

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Diagnostic potential of TSH to HDL cholesterol ratio in vulnerable carotid plaque identification

Contact Info

Product

Resources

About