Corrigendum: Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Venegas, Daniela Parada; Fuente, Marjorie K. De la; Landskron, Glauben; González, Marı́a Julieta; Quera, Rodrigo; Dijkstra, Gerard; Harmsen, Hermie J. M.; Faber, Klaas Nico; Hermoso, Marcela A.

doi:10.3389/fimmu.2019.01486

Cited by 242 publications

(105 citation statements)

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“…High response diversity and redundancy for acetate kinase is expected as acetate is the most abundant SCFA found in the human gut microbiome and is known to be encoded by diverse groups of bacteria [77][78][79]102]. Nevertheless, it is encouraging that we observed this trend in coprolites as further support that we picked up a gut microbiome profile.…”

Section: Discussionsupporting

confidence: 59%

“…The four keystone taxa identified in the Rio Zape coprolites are known members of the contemporary human gut microbiome, which provides a validation for prehistoric keystone taxa. Eubacterium biforme and P. succinatutens are commensals that can produce the SCFAs butyrate [79,93] and propionate [79,94], respectively, in addition to performing other functions. The role of Escherichia in the gut is variable and has been identified in both disease and health-associated states [5,95].…”

Section: Discussionmentioning

confidence: 99%

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Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus

Jacobson

Honap

Monroe

et al. 2020

Phil. Trans. R. Soc. B

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Human microbiome studies are increasingly incorporating macroecological approaches, such as community assembly, network analysis and functional redundancy to more fully characterize the microbiome. Such analyses have not been applied to ancient human microbiomes, preventing insights into human microbiome evolution. We address this issue by analysing published ancient microbiome datasets: coprolites from Rio Zape ( n = 7; 700 CE Mexico) and historic dental calculus ( n = 44; 1770–1855 CE, UK), as well as two novel dental calculus datasets: Maya ( n = 7; 170 BCE-885 CE, Belize) and Nuragic Sardinians ( n = 11; 1400–850 BCE, Italy). Periodontitis-associated bacteria ( Treponema denticola , Fusobacterium nucleatum and Eubacterium saphenum ) were identified as keystone taxa in the dental calculus datasets. Coprolite keystone taxa included known short-chain fatty acid producers ( Eubacterium biforme, Phascolarctobacterium succinatutens ) and potentially disease-associated bacteria ( Escherichia , Brachyspira) . Overlap in ecological profiles between ancient and modern microbiomes was indicated by similarity in functional response diversity profiles between contemporary hunter–gatherers and ancient coprolites, as well as parallels between ancient Maya, historic UK, and modern Spanish dental calculus; however, the ancient Nuragic dental calculus shows a distinct ecological structure. We detected key ecological signatures from ancient microbiome data, paving the way to expand understanding of human microbiome evolution. This article is part of the theme issue ‘Insights into health and disease from ancient biomolecules’.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus

Jacobson

Honap

Monroe

et al. 2020

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

show abstract

“…Finally, reprogramming of Mf using metabolites could become a promising approach to dampen intestinal inflammation. For instance, the short-chain fatty acid n-butyrate (365,366) and itaconate (327,367) induce anti-inflammatory program in Mfs, which could represent an opportunity to treat IBD (368).…”

Section: Monocytes and Macrophagesmentioning

confidence: 99%

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

Caër

Wick

2020

Front. Immunol.

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Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier integrity while controlling pathogen invasion by activating an appropriate immune response. However, in genetically predisposed individuals, uncontrolled immune activation to intestinal flora is thought to underlie the chronic mucosal inflammation that can ultimately result in IBD. Thus, MNPs are involved in fine-tuning mucosal immune system responsiveness and have a critical role in maintaining homeostasis or, potentially, the emergence of IBD. MNPs include monocytes, macrophages and dendritic cells, which are functionally diverse but highly complementary. Despite their crucial role in maintaining intestinal homeostasis, specific functions of human MNP subsets are poorly understood, especially during diseases such as IBD. Here we review the current understanding of MNP ontogeny, as well as the recently identified human intestinal MNP subsets, and discuss their role in health and IBD.

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“…Therefore, they undergo microbial breakdown and subsequent fermentation to the final products: SCFAs. Butyrate is mainly produced by Firmicutes, propionate is produced by Bacteroidetes, and acetate is made by most gut anaerobes [52]. Butyrate is the primary energy source for colonocytes and plays an important role in brain function and maintenance of the intestinal barrier.…”

Section: Carbohydratesmentioning

confidence: 99%

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

2020

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The gut microbiota (GM) is defined as the community of microorganisms (bacteria, archaea, fungi, viruses) colonizing the gastrointestinal tract. GM regulates various metabolic pathways in the host, including those involved in energy homeostasis, glucose and lipid metabolism, and bile acid metabolism. The relationship between alterations in intestinal microbiota and diseases associated with civilization is well documented. GM dysbiosis is involved in the pathogenesis of diverse diseases, such as metabolic syndrome, cardiovascular diseases, celiac disease, inflammatory bowel disease, and neurological disorders. Multiple factors modulate the composition of the microbiota and how it physically functions, but one of the major factors triggering GM establishment is diet. In this paper, we reviewed the current knowledge about the relationship between nutrition, gut microbiota, and host metabolic status. We described how macronutrients (proteins, carbohydrates, fat) and different dietary patterns (e.g., Western-style diet, vegetarian diet, Mediterranean diet) interact with the composition and activity of GM, and how gut bacterial dysbiosis has an influence on metabolic disorders, such as obesity, type 2 diabetes, and hyperlipidemia.

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Corrigendum: Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Cited by 242 publications

References 0 publications

Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus

Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

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