Corrigendum: Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice

Tsukano, Hiroaki; Horie, Minoru; Ohga, Shinpei; Takahashi, Kuniyuki; Kubota, Yamato; Hishida, Ryuichi; Takebayashi, Hirohide; Shibuki, Katsuei

doi:10.3389/fncir.2017.00039

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…However, the pathway from MGBv to A1 differs from the pathway from MGBv to A2. MGBv projections to A2 are broader, resulting in broader tuned individual neurons and more heterogeneous tuning between neighboring neurons ( 20 , 60 , 65 , 66 ). The heterogeneity of tuning in A2 may better equip this region to process stimuli with varying temporal components, such as vocalizations.…”

Section: Discussionmentioning

confidence: 99%

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex

Calhoun

Chen

2023

Proc. Natl. Acad. Sci. U.S.A.

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Coordinated functioning of the two cortical hemispheres is crucial for perception. The human auditory cortex (ACx) shows functional lateralization with the left hemisphere specialized for processing speech, whereas the right analyzes spectral content. In mice, virgin females demonstrate a left-hemisphere response bias to pup vocalizations that strengthens with motherhood. However, how this lateralized function is established is unclear. We developed a widefield imaging microscope to simultaneously image both hemispheres of mice to bilaterally monitor functional responses. We found that global ACx topography is symmetrical and stereotyped. In both male and virgin female mice, the secondary auditory cortex (A2) in the left hemisphere shows larger responses than right to high-frequency tones and adult vocalizations; however, only virgin female mice show a left-hemisphere bias in A2 in response to adult pain calls. These results indicate hemispheric bias with both sex-independent and -dependent aspects. Analyzing cross-hemispheric functional correlations showed that asymmetries exist in the strength of correlations between DM-AAF and A2-AAF, while other ACx areas showed smaller differences. We found that A2 showed lower cross-hemisphere correlation than other cortical areas, consistent with the lateralized functional activation of A2. Cross-hemispheric activity correlations are lower in deaf, otoferlin knockout (OTOF −/− ) mice, indicating that the development of functional cross-hemispheric connections is experience dependent. Together, our results reveal that ACx is topographically symmetric at the macroscopic scale but that higher-order A2 shows sex-dependent and independent lateralized responses due to asymmetric intercortical functional connections. Moreover, our results suggest that sensory experience is required to establish functional cross-hemispheric connectivity.

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Section: Discussionmentioning

confidence: 99%

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex

Calhoun

Chen

2023

Proc. Natl. Acad. Sci. U.S.A.

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“…Among rodents with lissencephalic brains, the separation of the insulo-parietal field from the more posterior core auditory fields appears to be well-documented only in rats 34,25,49 . In mice, an insular auditory field exists as well, but is continuous with the anterior auditory field (AAF) in the ventrorostral direction [29][30][31][32][33] . Thus, Sawatari et al 29 identified and characterized the insular auditory field in mice using wide-field calcium imaging followed by histological analysis.…”

Section: Insulo-parietal Auditory Field In Rodentsmentioning

confidence: 99%

“…This short survey shows that the posterior insula and the nearby somatosensory field provide an intriguing window into the role of secondary auditory fields. In rats and mice, the posterior insula is innervated by the MGB and contains auditory neurons 25,[28][29][30][31][32][33] . Also in rats, short-latency auditory responses were detected in both primary and secondary somatosensory fields 24,[34][35][36] .…”

Section: Introductionmentioning

confidence: 99%

A Rapid Anterior Auditory Processing Stream Through the Insulo-Parietal Auditory Field in the Rat

Jankowski,

Karayanni,

Harpaz

et al. 2023

Preprint

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The insular cortex is believed to be involved in a wide range of auditory functions in the mammalian brain. We studied the organization and basic response properties of auditory neurons in insular cortex and adjacent areas by recording responses to sound stimuli in anesthetized rats. Auditory neurons were present in an insulo-parietal auditory field that spans the boundary between the posterior insula, particularly in the granular insular cortex and the ventral part of the secondary somatosensory cortex. Neurons in this field had narrow tuning, were preferentially tuned to relatively low frequencies (<16 kHz), and had short response latencies. Intriguingly, some auditory units in this insulo-parietal field displayed shorter onset latencies than the minimal latency in primary auditory cortex. At the same time, these units showed weaker sensitivity to deviance than units in primary auditory cortex. These results establish the existence of a rapid information stream through the insulo-parietal cortex that may parallel the pathway through the primary and anterior auditory fields.

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A retrograde mechanism coordinates memory allocation across brain regions

Lavi

Sehgal

Sisan

et al. 2021

Preprint

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Memories engage ensembles of neurons across different brain regions within a memory system. However, it is unclear whether the allocation of a memory to these ensembles is coordinated across brain regions. To address this question, we used CREB expression to bias memory allocation in one brain region, and rabies retrograde tracing to test memory allocation in connected presynaptic neurons in the other brain regions. We find that biasing allocation of CTA memory in the basolateral amygdala (BLA) also biases memory allocation in presynaptic neurons of the insular cortex (IC). By manipulating the allocation of CTA memory to specific neurons in both BLA and IC, we found that we increased their connectivity and enhanced CTA memory performance. These results – which are corroborated by mathematical simulations, and by studies with auditory fear conditioning – demonstrate that a retrograde mechanism coordinates the allocation of memories across different brain regions.

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Corrigendum: Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice

Cited by 3 publications

References 2 publications

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex

A Rapid Anterior Auditory Processing Stream Through the Insulo-Parietal Auditory Field in the Rat

A retrograde mechanism coordinates memory allocation across brain regions

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