Corrigendum: Plasticity in One Hemisphere, Control From Two: Adaptation in Descending Motor Pathways After Unilateral Corticospinal Injury in Neonatal Rats

Wen, Tong-Chun; Lall, Sophia; Pagnotta, Corey; Markward, James; Gupta, Deepali; Ratnadurai-Giridharan, Shivakeshavan; Bucci, Jacqueline; Greenwald, Lucy; Klugman, Madelyn; Hill, N. Jeremy; Carmel, Jason B.

doi:10.3389/fncir.2018.00080

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with previous studies, the motor representation of the right forelimb in the TBI + sham group with spontaneous recovery was mapped to the RFA (Fig. 3, F and H) ( 16 , 21 ). However, in the TBI + CC7 group, the contralateral cortex showed a wide range of response areas, including the RFA and CFA, at 8 weeks after surgery.…”

Section: Resultssupporting

confidence: 89%

“…Animal studies have revealed that neonatally pyramidotomied rats can separately control impaired and healthy forelimbs, mainly due to the development of a new motor representative area of the impaired forelimb in the RFA region of the intact cortex ( 21 ). CSNs in the RFA terminate at all C2 to C7 levels and connect to premotor neurons, mostly innervating the proximal muscles.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Crossing nerve transfer drives sensory input–dependent plasticity for motor recovery after brain injury

et al. 2022

View full text Add to dashboard Cite

Restoring limb movements after central nervous system injury remains a substantial challenge. Recent studies proved that crossing nerve transfer surgery could rebuild physiological connectivity between the contralesional cortex and the paralyzed arm to compensate for the lost function after brain injury. However, the neural mechanism by which this surgery mediates motor recovery remains still unclear. Here, using a clinical mouse model, we showed that this surgery can restore skilled forelimb function in adult mice with unilateral cortical lesion by inducing cortical remapping and promoting corticospinal tract sprouting. After reestablishing the ipsilateral descending pathway, resecting of the artificially rebuilt peripheral nerve did not affect motor improvements. Furthermore, retaining the sensory afferent, but not the motor efferent, of the transferred nerve was sufficient for inducing brain remapping and facilitating motor restoration. Thus, our results demonstrate that surgically rebuilt sensory input triggers neural plasticity for accelerating motor recovery, which provides an approach for treating central nervous system injuries.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Crossing nerve transfer drives sensory input–dependent plasticity for motor recovery after brain injury

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although the underlying models are different, a smaller but significant body of evidence has supported the same approach of inhibiting the contralesional motor cortex in children with PS and HCP (Kirton, 2013b). Substantial preclinical (Martin et al, 2007;Friel et al, 2013;Friel et al, 2014;Wen et al, 2018) and human (Eyre, 2007;Staudt, 2007b) evidence following early brain injury supports a negative association between the relative preservation of ipsilateral corticospinal projections from the contralesional hemisphere to the affected hand and clinical motor function. Targeting these ipsilateral tracts on the contralesional side thus has the potential to improve motor function.…”

Section: Discussionmentioning

confidence: 99%

“…These neuromodulation approaches are based on evolving human and animal models of how the motor system develops following early unilateral injury (Eyre et al, 2007;Staudt, 2007a;Kirton, 2013b;Wen et al, 2018). Excessive preservation of motor control of the affected limb by the contralesional, ipsilateral hemisphere has led to trials trying "inhibitory" stimulation targeting contralesional M1.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Static Magnetic Field Stimulation of the Motor Cortex in Children

et al. 2020

View full text Add to dashboard Cite

Background: Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects on the developing brain are unstudied. Objective/Hypothesis: We aimed to determine the effects of tSMS on cortical excitability and motor learning in healthy children. We hypothesized that tSMS over right M1 would reduce cortical excitability and inhibit contralateral motor learning. Methods: This randomized, sham-controlled, double-blinded, three-arm, cross-over trial enrolled 24 healthy children aged 10-18 years. Transcranial Magnetic Stimulation (TMS) assessed cortical excitability via motor-evoked potential (MEP) amplitude and paired pulse measures. Motor learning was assessed via the Purdue Pegboard Test (PPT). A tSMS magnet (677 Newtons) or sham was held over left or right M1 for 30 min while participants trained the non-dominant hand. A linear mixed effect model was used to examine intervention effects. Results: All 72 tSMS sessions were well tolerated without serious adverse effects. Neither cortical excitability as measured by MEPs nor paired-pulse intracortical neurophysiology was altered by tSMS. Possible behavioral effects included contralateral tSMS inhibiting early motor learning (p < 0.01) and ipsilateral tSMS facilitating later stages of motor learning (p < 0.01) in the trained non-dominant hand. Conclusion: tSMS is feasible in pediatric populations. Unlike adults, tSMS did not produce measurable changes in MEP amplitude. Possible effects of M1 tSMS on motor learning require further study. Our findings support further exploration of tSMS neuromodulation in young children with cerebral palsy.

show abstract

“…11 Recent animal experiments have revealed that the regrowth of ipsilesional descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function. 12,13 The possible underlying mechanisms include the promotion of CST axonal sprouting in the unaffected hemisphere across the midline into the denervate (affected) area of the spinal cord. 14 However, due to the limited potential for axonal outgrowth in adults, neurological recovery is difficult to achieve.…”

Section: Introductionmentioning

confidence: 99%

Contralesional Anodal Transcranial Direct Current Stimulation Promotes Intact Corticospinal Tract Axonal Sprouting and Functional Recovery After Traumatic Brain Injury in Mice

Chen,

Tan,

Zhang

et al. 2024

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Background Anodal transcranial direct current stimulation (AtDCS), a neuromodulatory technique, has been applied to treat traumatic brain injury (TBI) in patients and was reported to promote functional improvement. We evaluated the effect of contralesional AtDCS on axonal sprouting of the intact corticospinal tract (CST) and the underlying mechanism in a TBI mouse model to provide more preclinical evidence for the use of AtDCS to treat TBI. Methods TBI was induced in mice by a contusion device. Then, the mice were subjected to contralesional AtDCS 5 days per week followed by a 2-day interval for 7 weeks. After AtDCS, motor function was evaluated by the irregular ladder walking, narrow beam walking, and open field tests. CST sprouting was assessed by anterograde and retrograde labeling of corticospinal neurons (CSNs), and the effect of AtDCS was further validated by pharmacogenetic inhibition of axonal sprouting using clozapine-N-oxide (CNO). Results TBI resulted in damage to the ipsilesional cortex, while the contralesional CST remained intact. AtDCS improved the skilled motor functions of the impaired hindlimb in TBI mice by promoting CST axon sprouting, specifically from the intact hemicord to the denervated hemicord. Furthermore, electrical stimulation of CSNs significantly increased the excitability of neurons and thus activated the mechanistic target of rapamycin (mTOR) pathway. Conclusions Contralesional AtDCS improved skilled motor following TBI, partly by promoting axonal sprouting through increased neuronal activity and thus activation of the mTOR pathway.

show abstract

Corrigendum: Plasticity in One Hemisphere, Control From Two: Adaptation in Descending Motor Pathways After Unilateral Corticospinal Injury in Neonatal Rats

Cited by 3 publications

References 0 publications

Crossing nerve transfer drives sensory input–dependent plasticity for motor recovery after brain injury

Crossing nerve transfer drives sensory input–dependent plasticity for motor recovery after brain injury

Transcranial Static Magnetic Field Stimulation of the Motor Cortex in Children

Contralesional Anodal Transcranial Direct Current Stimulation Promotes Intact Corticospinal Tract Axonal Sprouting and Functional Recovery After Traumatic Brain Injury in Mice

Contact Info

Product

Resources

About