[Corrigendum] Oral intake of royal jelly improves anti‑cancer effects and suppresses adverse events of molecular targeted therapy by regulating TNF‑α and TGF‑β in renal cell carcinoma: A preliminary study based on a randomized double‑blind clinical trial

The Incidence and Management of Cancer-Related Anorexia During Treatment with Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors

“…Royal jelly, a substance collected from honeybees, has been investigated for interactions with chemotherapeutic agents and potential anti-inflammatory effects, 113–115 and a previous study examining royal jelly revealed insights into the mechanism of TKI-induced anorexia. 116 Royal jelly affects the regulation of cytokines such as TNF-α and TGF-β; 117 , 118 and it has recently been considered for its potential to prevent TKI-induced anorexia. 116 , 118 Patients with RCC who received pre-treatment with royal jelly before TKIs had a reduction in TNF-α levels and an increase in TGF-β and macrophage colony-stimulating factor levels; however, the effect was transient and did not last beyond 12 weeks.…”

“… 116 Royal jelly affects the regulation of cytokines such as TNF-α and TGF-β; 117 , 118 and it has recently been considered for its potential to prevent TKI-induced anorexia. 116 , 118 Patients with RCC who received pre-treatment with royal jelly before TKIs had a reduction in TNF-α levels and an increase in TGF-β and macrophage colony-stimulating factor levels; however, the effect was transient and did not last beyond 12 weeks. 116 In another study, patients with RCC who received royal jelly had significantly lower rates of TKI-induced anorexia compared with those receiving placebo, 118 and fewer patients who received royal jelly required TKI dose reductions.…”

“… 116 , 118 Patients with RCC who received pre-treatment with royal jelly before TKIs had a reduction in TNF-α levels and an increase in TGF-β and macrophage colony-stimulating factor levels; however, the effect was transient and did not last beyond 12 weeks. 116 In another study, patients with RCC who received royal jelly had significantly lower rates of TKI-induced anorexia compared with those receiving placebo, 118 and fewer patients who received royal jelly required TKI dose reductions. Considering these findings, royal jelly is a promising candidate for its potential in preventing anorexia in patients with cancer.…”

Dietary Supplements in People with Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, and Frailty: A Scoping Review

“…Muscadine grape extract was investigated in a quasi-experimental trial in the form of capsules that were taken twice daily (each capsule containing ~160 mg phenolics) in five dose levels of 320 to 1600 mg total phenolics [52]. Royal jelly was administered in the form of 800 mg capsules three times daily (equivalent to 2400 mg daily), as per figures published in the erratum [82].…”

Effect of queen cell numbers on royal jelly production and quality

“…In recent years, RJ is attracting a progressively growing interest owing to consumers' awareness of its health-beneficial properties, e.g. anti-cancer ( Miyata et al, 2020 ; Albalawi et al, 2022 ), antioxidant ( Pavel et al, 2014 ), anti-aging ( Ali and Kunugi, 2020 ), antimicrobial ( Fratini et al, 2016 ), anti-inflammatory ( Chen et al, 2016 ), and immunomodulatory effects ( Gasic et al, 2007 ). It has thus shown great potential for use against various disorders such as cancer, diabetic, cardiovascular, Parkinson's, and Alzheimer's diseases ( Ahmad et al, 2020 ; Ali and Kunugi, 2020 ).…”