Corrigendum: MiR-183-5p Promotes Proliferation, Metastasis and Angiogenesis in Breast Cancer Cells through Negatively Regulating Four and a Half LIM Protein 1

Li, Yi; Zeng, Qing'an; Qiu, Jiliang; Pang, Ting; Ye, Fenglian; Huang, Lin; Zhang, Xuexia

doi:10.4048/jbc.2020.23.e50

Cited by 5 publications

(1 citation statement)

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“…However, FHL1 appeared to execute opposite functions in tumor cells. FHL1 suppressed growth of colorectal cancer cells and the metastasis of breast cancer cells [25,26]. In lung cancer, inhibition of cell growth by FHL1 was associated with both G1 and G2/M cell cycle arrest concomitant with marked inhibition of cyclins [27].…”

Section: Introductionmentioning

confidence: 99%

VE-822 Upregulates the Deubiquitinase OTUD1 to Stabilize FHL1 to Inhibit the Progression of Lung Adenocarcinoma

Zhang

Chen

et al. 2022

SSRN Journal

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Section: Introductionmentioning

confidence: 99%

VE-822 Upregulates the Deubiquitinase OTUD1 to Stabilize FHL1 to Inhibit the Progression of Lung Adenocarcinoma

Zhang

Chen

et al. 2022

SSRN Journal

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

Zhang

Chen

et al. 2023

Cell Oncol.

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BackgroundThe deubiquitinase ovarian tumor domain-containing 1 (OTUD1) has been considered as a tumor suppressor in many tumors, but there is minimal research on the role of OTUD1 in lung adenocarcinoma (LUAD) pathogenesis. MethodsBioinformatics analyses and western blot were applied for investigating OTUD1 expression in lung cancer and the drug that upregulated OTUD1. Kaplan-Meier analysis with log-rank test was used for survival analyses. IP-MS and co-IP were performed for identifying potential protein interactions with OTUD1. In vitro and in vivo assays were used for exploring the function of OTUD1 during the progression of LUAD. ResultsOTUD1 was dramatically downregulated in tumors and cell lines of human lung cancer. OTUD1 inhibited proliferation and migration of lung cancer cells in vitro. Moreover, OTUD1 inhibited growth of xenografts in nude mice and formation of primary lung tumors in urethane-induced lung cancer model.Mechanistically, we showed that OTUD1 deubiquitinated and stabilized FHL1. Furthermore, we listed and identi ed VE-822 as a candidate agonist for OTUD1. VE-822 inhibited proliferation of lung adenocarcinoma both in vitro and in vivo. ConclusionsThese results indicated that the deubiquitinase OTUD1, which was upregulated by VE-822, inhibited the progression of LUAD in vitro and in vivo by deubiquitinating and stabilizing FHL1.

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Synergistic apoptotic effect of miR-183-5p and Polo-Like kinase 1 inhibitor NMS-P937 in breast cancer cells

et al. 2021

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MicroRNAs (miRNAs) are small noncoding RNAs that act as endogenous regulatory molecules targeting specific mRNAs for translational repression. Studies of breast cancer genomics indicate that breast cancer subtypes are distinguished and regulated by specific sets of miRNAs which affect activities such as tumor initiation, progression, and even drug response. Polo-like Kinase 1 (PLK1) is widely considered to be a proto-oncogene due to its increased expression in multiple tumor types, as well as its crucial role in regulating mitosis. Pharmacological inhibition of PLK1 can reduce tumor volume and induce tumor cell death in solid and hematologic malignancies. This prompted us to investigate how PLK1 inhibition with the target-specific inhibitor NMS-P937 would impact breast cancer cells, and how miRNAs may influence the overall response of these cells to this inhibition. We found that miR-183-5p targets PLK1 gene, effectively reducing its protein expression. Such miRNA-driven regulation of PLK1 expression sensitizes breast cancer cells to NMS-P937, resulting in synergistically increased apoptosis. We also show that the miRNA-regulated reduction of PLK1 influences the expression of apoptosis-related key proteins and possibly inducing further indirect PLK1 downmodulation through a DNMT1-p53 axis. These results suggest a potential biologically significant link between the expression of miR-183-5p and the efficacy of PLK1-specific inhibitors in breast cancer cells. Our work further elucidates how miR-183-5p regulates PLK1 gene while also enhancing NMS-P937 effect in breast cancer. Future studies assessing the role of miR-183-5p as a novel biomarker for anti-PLK1 chemotherapy agents are warranted.

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Corrigendum: MiR-183-5p Promotes Proliferation, Metastasis and Angiogenesis in Breast Cancer Cells through Negatively Regulating Four and a Half LIM Protein 1

Cited by 5 publications

References 0 publications

VE-822 Upregulates the Deubiquitinase OTUD1 to Stabilize FHL1 to Inhibit the Progression of Lung Adenocarcinoma

VE-822 Upregulates the Deubiquitinase OTUD1 to Stabilize FHL1 to Inhibit the Progression of Lung Adenocarcinoma

VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

Synergistic apoptotic effect of miR-183-5p and Polo-Like kinase 1 inhibitor NMS-P937 in breast cancer cells

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