Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

Orecchioni, Marco; Ghosheh, Yanal; Pramod, Akula Bala; Ley, Klaus

doi:10.3389/fimmu.2020.00234

Cited by 47 publications

(39 citation statements)

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“…The discrepancy in regard to the influence of Cx43 in Mϕ polarization to the M1 type, may alternatively be due to the inherent difficulties in identifying the Mϕ polarization, as markers used for identification of polarization in vitro were found to not always work in vivo. For instance, genes modulated inside the iNOS signaling pathway were found to differ slightly compared to in vitro Mϕs [66].…”

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confidence: 99%

Function of Connexin-43 in Macrophages

Rodjakovic

Salm

Beldi

2021

IJMS

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Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory regulation in the lungs and in macrophage-differentiation. Its relevance in pathophysiology becomes evident in inflammatory bowel disease (IBD), tumours and HIV, in which aberrant functioning of Cx43 has been described. However, the involvement of Cx43 in other Mφ functions, such as phagocytosis and polarisation, and its involvement in other types of local and systemic inflammation, are still unclear and need further research.

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confidence: 99%

Function of Connexin-43 in Macrophages

Rodjakovic

Salm

Beldi

2021

IJMS

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“…These results indicate that the YB1 could induce neutrophils and macrophages gathering, which mediated phagocytosis in tumors. In addition, iNOS is often used as a marker of M1-like macrophages ( 36 ), its upregulation may indicate the possible enrichment of M1 macrophages.…”

Section: Resultsmentioning

confidence: 99%

Tumor Temporal Proteome Profiling Reveals the Immunological Triple Offensive Induced by Synthetic Anti-Cancer Salmonella

et al. 2021

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The engineered “obligate” anaerobic Salmonella typhimurium strain YB1 shows a prominent ability to repress tumor growth and metastasis, which has great potential as a novel cancer immunotherapy. However, the antitumor mechanism of YB1 remains unelucidated. To resolve the proteome dynamics induced by the engineered bacteria, we applied tumor temporal proteome profiling on murine bladder tumors after intravenous injection of either YB1 or PBS as a negative control. Our data suggests that during the two weeks treatment of YB1 injections, the cured tumors experienced three distinct phases of the immune response. Two days after injection, the innate immune response was activated, particularly the complement and blood coagulation pathways. In the meantime, the phagocytosis was initiated. The professional phagocytes such as macrophages and neutrophils were recruited, especially the infiltration of iNOS+ and CD68+ cells was enhanced. Seven days after injection, substantial amount of T cells was observed at the invasion margin of the tumor. As a result, the tumor shrunk significantly. Overall, the temporal proteome profiling can systematically reveal the YB1 induced immune responses in tumor, showing great promise for elucidating the mechanism of bacteria-mediated cancer immunotherapy.

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“…This classification shows extreme phenotypes of complex activation states. As a rule, M1 macrophages are polarized by Th1 cytokines (for example, interferon (IFN-γ) and TNF) and molecular complexes linked with pathogens (PAMPs) consisting of lipopolysaccharides and lipoproteins [ 18 ]. Through the regulatory interferon factor 5 (IRF5), the granulocyte-macrophage colony-stimulating factor (GM-CSF) participates in the inflammatory process.…”

Section: Inflammatory Role Of M1 and M2 Macrophagesmentioning

confidence: 99%

Macrophages and Foam Cells: Brief Overview of Their Role, Linkage, and Targeting Potential in Atherosclerosis

et al. 2021

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Atherosclerosis is still one of the main causes of death around the globe. This condition leads to various life-threatening cardiovascular complications. However, no effective preventive measures are known apart from lifestyle corrections, and no cure has been developed. Despite numerous studies in the field of atherogenesis, there are still huge gaps in already poor understanding of mechanisms that underlie the disease. Inflammation and lipid metabolism violations are undoubtedly the key players, but many other factors, such as oxidative stress, endothelial dysfunction, contribute to the pathogenesis of atherosclerosis. This overview is focusing on the role of macrophages in atherogenesis, which are at the same time a part of the inflammatory response, and also tightly linked to the foam cell formation, thus taking part in both crucial for atherogenesis processes. Being essentially involved in atherosclerosis development, macrophages and foam cells have attracted attention as a promising target for therapeutic approaches.

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Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

Cited by 47 publications

References 0 publications

Function of Connexin-43 in Macrophages

Function of Connexin-43 in Macrophages

Tumor Temporal Proteome Profiling Reveals the Immunological Triple Offensive Induced by Synthetic Anti-Cancer Salmonella

Macrophages and Foam Cells: Brief Overview of Their Role, Linkage, and Targeting Potential in Atherosclerosis

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