[Corrigendum] Long non‑coding RNA�H19 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma

Hong, Yonglong; He, Hai‐Tao; Sui, Wen; Zhang, Jingge; Zhang, Shenfu; Yang, Dajiang

doi:10.3892/ijo.2018.4428

Cited by 21 publications

(5 citation statements)

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“…Although a similar relationship between H19 and Id2 has been indicated previously in bladder cancer cells and acute myelocytic leukemia cells, the underlying mechanistic relationship between them have not been well investigated [17, 18]. Inspired by the newly reported regulatory mechanism that H19 functioned as a competing endogenous RNA (ceRNA) via sponging miRNA [19–21, 28–30], we employed bioinformatics analysis to predict that H19 promoted Id2 expression via acting as a ceRNA by sponging miR-19a. With dual luciferase reported assay, RIP and pull-down experiments, we demonstrated the dual competitive interaction of miR-19a with H19 and the 3′-UTR of Id2 mRNA.…”

Section: Discussionmentioning

confidence: 91%

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

Xiao

Qiu

Lin

et al. 2019

Aging

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Elevated expression of lncRNA H19 ( H19 ) in the setting of hypoxia has been implicated as a promising therapeutic target for various cancers. However, little is known about the impact and underlying mechanism of H19 in ischemic brain stroke. This study found that H19 levels were elevated in the serum of stroke patients, as well as in the ischemic penumbra of rats with middle cerebral artery occlusion/reperfusion (MCAO/R) injury and neuronal cells with oxygen glucose deprivation (OGD). Further, knockdown of H19 with siRNA alleviated cell apoptosis in OGD neuronal cells, and inhibition of H19 in MCAO/R rats significantly decreased neurological deficit, brain infarct volume and neuronal apoptosis. Lastly, with gain and loss of function studies, dual luciferase reported assay, RNA immunoprecipitation (RIP) and pull-down experiments, we demonstrated the dual competitive interaction of miR-19a with H19 and the 3’-UTR of Id2 mRNA, resulting in the identification of the H19 -miR-19a-Id2 axis. With biological studies, we also revealed that H19 -miR-19a-Id2 axis modulated hypoxia induced neuronal apoptosis. This study demonstrates that the identified H19 -miR-19a-Id2 axis plays a critical role in hypoxia induced neuronal apoptosis, and blocking this axis may serve as a novel therapeutic strategy for ischemic brain injury.

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Section: Discussionmentioning

confidence: 91%

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

Xiao

Qiu

Lin

et al. 2019

Aging

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“…Accumulating evidences indicated that lncRNAs exerted the function by interacting with miRNAs . Therefore, to uncover potential target miRNAs of MEG3, the bioinformatics prediction analysis was performed by miRDB online website.…”

Section: Resultsmentioning

confidence: 99%

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

Tan

Xiang

2019

IUBMB Life

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Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, however, its functional mechanism remains uncertain. Here, we found that the overexpression of MEG3 suppressed migration and promoted apoptosis in OSCC cell lines, while inhibition of MEG3 exhibited opposite effect. We also found that MEG3 could effectively sponge miR‐548d‐3p and decrease its expression level. Moreover, miR‐548d‐3p repressed the expression of SOCS5 and SOCS6 through binding their 3’UTR, thereby modulating the JAK–STAT signaling pathway and functioning as an oncogene in OSCC cells. Importantly, overexpression of MEG3 enhanced the expression of SOCS5 and SOCS6 to regulate JAK–STAT pathway, whereas miR‐548d‐3p overexpression decreased the effects of MEG3 on levels of SOCS5/SOCS6. Furthermore, upregulated expression of miR‐548d‐3p could abrogate the effect of MEG3 overexpression on migration and apoptosis in OSCC cell lines. In addition, the overexpression of MEG3 inhibited tumor migration and facilitated apoptosis in vivo. Together, our results revealed that MEG3 could modulate JAK–STAT pathway via miR‐548d‐3p/SOCS5/SOCS6 to suppresses migration and promote apoptosis in OSCC. Our research indexed a new functional mechanism of MEG3 in OSCC, and this mechanism may be a potential prognostic factor and therapeutic target. © 2019 IUBMB Life, 2019

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“…EZH2 is regulated by H19, through sponging of miR-630 (Li et al, 2016). Additionally, and through sponging miR-130, it was reported that H19 regulate EZH2 expression (Hong et al 2018). The functional outputs of H19-EZH2 association have been reported in a number of studies and using di erent models.…”

Section: H19 Lncrna Epigenetically Modulate Gene Expressionmentioning

confidence: 99%

The long Non-coding RNA Orchestrator of Cancer Axis of Evil Insights into the Multiple Modes of Action of the H19 Gene

Matouk

2021

AQUJ

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Increasing evidence has indicated that the non-coding RNA molecules play central roles in almost all biological processes and many pathological conditions including carcinogenesis. This review focuses on the pathological tumorigenic role of the first discovered long non-coding RNA gene called H19 and its pivotal contribution to the cancer axis of evil. H19 RNA utilizes a variety of mechanisms to perform its pathological function. Some key unanswered questions are presented by the end. Understanding the H19 RNA mechanisms of action will shed light into the class of long non-coding RNA which contains thousands of members mostly with unknown function and will help in delineating the pathological role played by at least some of them.

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[Corrigendum] Long non‑coding RNA�H19 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma

Cited by 21 publications

References 0 publications

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

The long Non-coding RNA Orchestrator of Cancer Axis of Evil Insights into the Multiple Modes of Action of the H19 Gene

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