Corrigendum: Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A

Beattie, James; Al-Khafaji, Hasanain; Noer, Pernille Rimmer; Alkharobi, Hanaa Esa; Alhodhodi, Aishah; Meade, Josephine L.; El-Gendy, Reem; Oxvig, Claus

doi:10.3389/fendo.2018.00510

Cited by 5 publications

(2 citation statements)

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“…The pathogenesis of GIO was predominantly attributed to the fact that GCs impaired bone formation by reduction of osteoblast differentiation and activity via the expression of the osteoblast-specific transcription factor runt-related Runx2 (95)(96)(97). In addition, the long-term GC administration affects bone remodeling by whittling the insulin-like growth factor (IGF) in ossification (98). GCs enhanced the expression levels of RANKL in both osteoblasts and stromal cells, which triggered osteoclastogenesis and activated osteoclastic bone resorption by binding to the RANKL receptor RANK (99), thus resulting in the primary phase of rapid bone loss.…”

Section: The Regulatory Roles Of T Cells In Pth-induced Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

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Immune imbalance caused bone loss. Osteoimmunology is emerging as a new interdisciplinary field to explore the shared molecules and interactions between the skeletal and immune systems. In particular, T lymphocytes (T cells) play pivotal roles in the regulation of bone health. However, the roles and mechanisms of T cells in the treatment of osteoporosis are not fully understood. The present review aims to summarize the essential regulatory roles of T cells in the pathophysiology of various cases of osteoporosis and the development of T cell therapy for osteoporosis from osteoimmunology perspective. As T cell-mediated immunomodulation inhibition reduced bone loss, there is an increasing interest in T cell therapy in an attempt to treat osteoporosis. In summary, the T cell therapy may be further pursued as an immunomodulatory strategy for the treatment of osteoporosis, which can provide a novel perspective for drug development in the future.

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Section: The Regulatory Roles Of T Cells In Pth-induced Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

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“…As such, they modulate interactions with IGF receptor molecules on specific tissues depending on the IGFBP (Dell et al, 1999). For example, IGF signaling exerts anabolic effects on mature bone growth in mice and humans, but also influences the development of osteoblasts during ontogeny (Beattie et al, 2018). The IGFBPs therefore constitute a mechanism for fine-tuning bone growth and development (Clemmons, 2018), which is highly relevant to performance (Arnold, 1983).…”

Section: Ils and Mtormentioning

confidence: 99%

Conserved and convergent mechanisms underlying performance–life-history trade-offs

Husak

Lailvaux

2022

Journal of Experimental Biology

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Phenotypic trade-offs are inevitable in nature, but the mechanisms driving them are poorly understood. Movement and oxygen are essential to all animals, and as such, the common ancestor to all living animals passed on mechanisms to acquire oxygen and contract muscle, sometimes at the expense of other activities or expression of traits. Nevertheless, convergent pathways have also evolved to deal with critical trade-offs that are necessary to survive ubiquitous environmental challenges. We discuss how whole-animal performance traits, such as locomotion, are important to fitness, yet costly, resulting in trade-offs with other aspects of the phenotype via specific conserved and convergent mechanistic pathways across all animals. Specifically, we discuss conserved pathways involved in muscle structure and signaling, insulin/insulin-like signaling, sirtuins, mitochondria and hypoxia-inducible factors, as well as convergent pathways involved in energy regulation, development, reproductive investment and energy storage. The details of these mechanisms are only known from a few model systems, and more comparative studies are needed. We make two main recommendations as a framework for future studies of animal form and function. First, studies of performance should consider the broader life-history context of the organism, and vice versa, as performance expression can require a large portion of acquired resources. Second, studies of life histories or mechanistic pathways that measure performance should do so in meaningful and standardized ways. Understanding proximate mechanisms of phenotypic trade-offs will not only better explain the phenotypes of the organisms we study, but also allow predictions about phenotypic variation at the evolutionary scale.

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Study of Novel Platelet Lysate Film-Forming Spray on Burn Wounds in Rats

Liu²,

Zhu³

et al. 2022

Pharm Chem J

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Corrigendum: Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A

Cited by 5 publications

References 0 publications

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Conserved and convergent mechanisms underlying performance–life-history trade-offs

Study of Novel Platelet Lysate Film-Forming Spray on Burn Wounds in Rats

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