Corrigendum: Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction

Pinget, Gabriela Veronica; Tan, Jian; Janac, Bartlomiej; Kaakoush, Nadeem O.; Angelatos, Alexandra S.; O’Sullivan, John; Koay, Yen Chin; Sierro, Frédéric; Davis, Joel; Divakarla, Shiva Kamini; Khanal, Dipesh; Moore, Robert J.; Stanley, Dragana; Chrzanowski, Wojciech; Macia, Laurence

doi:10.3389/fnut.2019.00100

Cited by 6 publications

(5 citation statements)

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“…The effects of the non-absorbable markers PEG-4000 63 , 64 and TiO 2 65 , 66 , 67 , 68 , 69 , 70 on the microbiota are expected to be minor. Possibly at some time points we sampled more mucus, resulting in a higher fraction of mucus-related bacteria such as Haemophilus .…”

Section: Discussionmentioning

confidence: 99%

Intraintestinal fermentation of fructo- and galacto-oligosaccharides and the fate of short-chain fatty acids in humans

van Trijp,

Rios-Morales,

Witteman

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Intraintestinal fermentation of fructo- and galacto-oligosaccharides and the fate of short-chain fatty acids in humans

van Trijp,

Rios-Morales,

Witteman

et al. 2024

iScience

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“…While water supplementation with TiO 2 (10 mg/kg body weight/day) for 7 days reduced Tregs in Peyer's patches in rats ( 87 ), the addition of TiO 2 into food had no impact ( 88 ). In mice, the addition of TiO 2 to drinking water for 3–4 weeks at either a physiological (10 mg/kg body weight) or high-dose (50 mg/kg/body weight) had no impact on Treg ( 85 ). Emulsifiers are used to improve food texture and have been shown to exacerbate obesity and colitis in mice via effects on the gut microbiota ( 89 ).…”

Section: Impact Of Diet On Treg Developmentmentioning

confidence: 99%

“…Food additives are prevalent in modern diets and added to processed food for various reasons, such as increasing shelf-life and improving texture. The whitening agent titanium dioxide (TiO 2 ) is one of the most common food additives ( 85 , 86 ), and its reported effects on pTreg appear inconsistent. While water supplementation with TiO 2 (10 mg/kg body weight/day) for 7 days reduced Tregs in Peyer's patches in rats ( 87 ), the addition of TiO 2 into food had no impact ( 88 ).…”

Section: Impact Of Diet On Treg Developmentmentioning

confidence: 99%

Your Regulatory T Cells Are What You Eat: How Diet and Gut Microbiota Affect Regulatory T Cell Development

et al. 2022

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Modern industrial practices have transformed the human diet over the last century, increasing the consumption of processed foods. Dietary imbalance of macro- and micro-nutrients and excessive caloric intake represent significant risk factors for various inflammatory disorders. Increased ingestion of food additives, residual contaminants from agricultural practices, food processing, and packaging can also contribute deleteriously to disease development. One common hallmark of inflammatory disorders, such as autoimmunity and allergies, is the defect in anti-inflammatory regulatory T cell (Treg) development and/or function. Treg represent a highly heterogeneous population of immunosuppressive immune cells contributing to peripheral tolerance. Tregs either develop in the thymus from autoreactive thymocytes, or in the periphery, from naïve CD4+ T cells, in response to environmental antigens and cues. Accumulating evidence demonstrates that various dietary factors can directly regulate Treg development. These dietary factors can also indirectly modulate Treg differentiation by altering the gut microbiota composition and thus the production of bacterial metabolites. This review provides an overview of Treg ontogeny, both thymic and peripherally differentiated, and highlights how diet and gut microbiota can regulate Treg development and function.

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“…at the dose of 10 and 50 mg/kg BW/day) resulted in more significant connections within the network, as well as increased number of genera with significant contributions. Authors report that, while Akkermansia was not significantly involved in the microbial network of mice administered 0, 2, or 10 mg TiO2/kg BW/day, it is involved at a dose of 50 mg/kg involving numerous co-exclusion relationships (69). This recent evidence suggest that TiO 2 NPs could impair gut homeostasis which may in turn prime the host for disease development.…”

Section: Titanium Dioxide (Tio 2 ) Npsmentioning

confidence: 99%

Modulation of Gut Microbiota by Essential Oils and Inorganic Nanoparticles: Impact in Nutrition and Health

et al. 2022

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Microbiota plays a crucial role in human health and disease; therefore, the modulation of this complex and yet widely unexplored ecosystem is a biomedical priority. Numerous antibacterial alternatives have been developed in recent years, imposed by the huge problem of antibioresistance, but also by the people demand for natural therapeutical products without side effects, as dysbiosis, cyto/hepatotoxicity. Current studies are focusing mainly in the development of nanoparticles (NPs) functionalized with herbal and fruit essential oils (EOs) to fight resistant pathogens. This is due to their increased efficiency against susceptible, multidrug resistant and biofilm embedded microorganisms. They are also studied because of their versatile properties, size and possibility to ensure a targeted administration and a controlled release of bioactive substances. Accordingly, an increasing number of studies addressing the effects of functional nanoparticles and plant products on microbial pathogens has been observed. Regardless the beneficial role of EOs and NPs in the treatment of infectious diseases, concerns regarding their potential activity against human microbiota raised constantly in recent years. The main focus of current research is on gut microbiota (GM) due to well documented metabolic and immunological functions of gut microbes. Moreover, GM is constantly exposed to micro- and nano-particles, but also plant products (including EOs). Because of the great diversity of both microbiota and chemical antimicrobial alternatives (i.e., nanomaterials and EOs), here we limit our discussion on the interactions of gut microbiota, inorganic NPs and EOs. Impact of accidental exposure caused by ingestion of day care products, foods, atmospheric particles and drugs containing nanoparticles and/or fruit EOs on gut dysbiosis and associated diseases is also dissected in this paper. Current models developed to investigate mechanisms of dysbiosis after exposure to NPs/EOs and perspectives for identifying factors driving EOs functionalized NPs dysbiosis are reviewed.

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Corrigendum: Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction

Cited by 6 publications

References 0 publications

Intraintestinal fermentation of fructo- and galacto-oligosaccharides and the fate of short-chain fatty acids in humans

Intraintestinal fermentation of fructo- and galacto-oligosaccharides and the fate of short-chain fatty acids in humans

Your Regulatory T Cells Are What You Eat: How Diet and Gut Microbiota Affect Regulatory T Cell Development

Modulation of Gut Microbiota by Essential Oils and Inorganic Nanoparticles: Impact in Nutrition and Health

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