Corrigendum: Homocysteine levels in schizophrenia and affective disorders—focus on cognition

Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder

“…There is a huge amount of scientific literature demonstrating that alteration in homocysteine concentration (mainly an increased concentration in blood) is associated with several neuropsychiatric diseases and cognitive impairment in elderly people (Obeid et al, 2007;Moustafa et al, 2014). Increased homocysteine in urine might reflect an increase levels in the blood and thus in the brain because this amino acid easily crosses the blood-brain barrier (Obeid et al, 2007).…”

Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine

“…The direct mechanism by which this occurs remains unknown, however, it has been postulated that tetrahydrobiopterin (BH4) metabolism, a cofactor for the synthesis of monoamine neurotransmitters which has some structural similarities to folic acid, could be involved (Bottiglieri, 2005). It has been suggested that supplementation with B vitamins, in particular folic acid, could be a beneficial strategy for schizophrenic patients since they mainly attenuate the negative symptoms of the disorder (Moustafa et al, 2014).…”

Role of cystathionine β-synthase in human breast Cancer

“…It is well known that CBS regulates the steady state levels of homocysteine (Hcy), a sulfur-containing amino acid, the accumulation of which leads to cellular toxicity associated with a variety of diseases including those of the cardiovascular and neurological systems [1][2][3]. CBS, which can catalyze the condensation of Hcy and cysteine (Cys) to hydrogen sulfide (H 2 S) and cystathionine (CTH) [4,5], may play an important role in breast cancer as well.…”