[Corrigendum] HK2 is associated with the Warburg effect and proliferation in liver cancer: Targets for effective therapy with glycyrrhizin

Sun, Zengpeng; Tan, Zhiguo; Peng, Chuang; Yi, Wu

doi:10.3892/mmr.2021.12143

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…Herein, although the licorice samples of Moroccan and Syrian origin revealed a high glucose uptake, the comparative activity was lower than for the standard drug metformin. A dose-dependent stimulation of glucose uptake has been reported for licorice constituents such as glabridin [ 25 ] and glycyrrhizin [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity

et al. 2022

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Background: Geographical variation may affect the phytochemistry as well as the biological activities of Glycyrrhiza glabra (licorice) root. Herein, a series of biological activities were performed to evaluate the impact of geographical origin on the biological potential of eight different licorice samples. Methodology: Cell culture studies were performed for cytotoxicity (MCF7, HCT116, HepG2, and MRC5), glucose uptake assay (HepG2), and glutathione peroxidase activity (HepG2), whereas α-amylase inhibition activity was tested for antidiabetic potential. Results: The Indian sample was observed to be more cytotoxic against MCF7 (22%) and HCT116 (43%) with an IC50 value of 56.10 (±2.38) μg/mL against the MCF7 cell line. The glucose uptake was seen with a mean value of 96 (±2.82) and a range of 92–101%. For glutathione peroxidase activity (GPx), the Syrian (0.31 ± 0.11) and Pakistani samples (0.21 ± 0.08) revealed a significant activity, whereas the Palestinian (70 ± 0.09) and Indian samples (68±0.06) effectively inhibited the α-amylase activity, with the lowest IC50 value (67.11 ± 0.97) μg/mL for the Palestinian sample. The statistical models of PCA (principal component analysis) and K-mean cluster analysis were performed to correlate the geographical origin, extract yield, and biological activities for the eight licorice samples of different origins. Conclusion: The licorice samples exhibited significant cytotoxic, GPx, and α-amylase inhibitory activity. The samples with higher extract yield showed more potential in these biological activities.

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Section: Discussionmentioning

confidence: 99%

Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity

et al. 2022

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“…Growing evidence suggests that cancer cells prefer to utilize enzyme of glycolysis for the Warburg effect to satisfy the growing needs of nucleotide, lipid, and protein for cell proliferation. [ 1 , 2 ] Several rate-limiting enzymes are involved in the process of glycolysis, such as pyruvate kinase M2, [ 3 ] fructose-1, 6-bisphosphatase, [ 2 ] pyruvate dehydrogenase, [ 4 ] and Hexokinase-2, [ 5 ] which aberrant expression leads to cancer development and progression. Therefore, it is critical to investigate the correlation between glycolysis and various cancers.…”

Section: Introductionmentioning

confidence: 99%

Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers

Zhao

Xu²

2023

Medicine

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Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (TIMER2, GEPIA2, UALCAN, cBioPortal, and MXPRESS) and R language to identify the correlation between the ALDOB expression and survival analysis, genetic alteration, DNA methylation, and immune cell infiltration based on The Cancer Genome Atlas project. The results showed that ALDOB was lowly expressed in pan-cancer. Survival analysis revealed that low expression of ALDOB was markedly related with poor clinical prognosis, while the genetic alteration within ALDOB changed along with the difference of overall survival (OS) and disease-free survival (DFS) prognosis in several cancers. A possible relationship between DNA methylation and ALDOB expression for several tumors was found. Besides, ALDOB expression was confirmed to be associated with tumor immune cell infiltration, especially in breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), and testicular germ cell tumors (TGCT) cases. Further, the enrichment analysis demonstrated that metabolic pathway was closely related to ALDOB expression. Our results provide a comprehensive pan-cancer analysis and suggest ALDOB could act as a promising tumor predictive biomarker for human cancer.

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Plant-based foods and hepatocellular carcinoma: A review on mechanistic understanding

Saeed

Maqsood

Saeed

et al. 2022

Critical Reviews in Food Science and Nutrition

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[Corrigendum] HK2 is associated with the Warburg effect and proliferation in liver cancer: Targets for effective therapy with glycyrrhizin

Cited by 9 publications

References 28 publications

Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity

Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity

Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers

Plant-based foods and hepatocellular carcinoma: A review on mechanistic understanding

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