[Corrigendum] Epigenetics of oral and oropharyngeal cancers (Review)

Russo, Daniela; Merolla, Francesco; Varricchio, Silvia; Salzano, Giovanni; Zarrilli, Giovanni; Mascolo, Massimo; Strazzullo, Viviana; Crescenzo, Rosa Maria Di; Celetti, Angela; Ilardi, Gennaro

doi:10.3892/br.2020.1290

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epigenetics in oral carcinogenesis can be frequently modulated by endogenous, as well as environmental factors. Among them, tobacco smoking, alcohol consumption, and human papillomavirus (HPV) persistent infection play a significant role ( Lleras et al, 2013 ; Kumar et al, 2015 ; Degli Esposti et al, 2017 ; Russo et al, 2020 ). These factors have already been linked to perineural invasion occurrence in head and neck squamous cell carcinoma ( Baumeister et al, 2018 ; Al Feghali et al, 2019 ).…”

Section: Epigenetic Regulations and Their Association With Perineural...mentioning

confidence: 99%

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

et al. 2022

View full text Add to dashboard Cite

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion’s extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.

show abstract

Section: Epigenetic Regulations and Their Association With Perineural...mentioning

confidence: 99%

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…While infection with human papillomavirus accounts for an increasing number of patients with oropharyngeal cancers, risk factors, especially viruses, in OSCC nonsmokers and non-drinkers, are unclear 11,12 . Head and neck cancer (HNC), including OSCC, is a heterogeneous disease that develops through a complex, multi-step process involving genetic alterations, growth regulation, apoptosis, angiogenesis, invasion and metastasis; moreover, it is influenced by the individual's genetic predisposition and environmental exposure to carcinogens 13,14 . This heterogeneity is confirmed in daily practice by the observation that patients with clinically similar tumours have different treatment responses and outcomes 15,16 .…”

Section: Introductionmentioning

confidence: 99%