Corrigendum: Direct Relay Pathways from Lemniscal Auditory Thalamus to Secondary Auditory Field in Mice

Ohga, Shinpei; Tsukano, Hiroaki; Horie, Minoru; Terashima, Hiroki; Nishio, Nana; Kubota, Yamato; Takahashi, Kuniyuki; Hishida, Ryuichi; Takebayashi, Hirohide; Shibuki, Katsuei

doi:10.1093/cercor/bhz097

Cited by 3 publications

(1 citation statement)

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“…Inputs from A1, A2, and the MGm to the TeA play roles in inducing the CS according to auditory information, CS lateral inhibition, and non-frequency-specific sensitization A1 belongs to the lemniscal nuclei, while A2 and the MGm belong to the nonlemniscal nuclei (Hu, 2003;Ohga et al, 2021). Following Suga's working model of tuning shifts (Suga, 2012(Suga, , 2020, the CS-dependent tuning of TeA neurons might be induced by auditory information from the lemniscal nuclei (e.g., A1 and the MGv) sensitized by the nonlemniscal nuclei (e.g., A2 and the MGm).…”

Section: Cs Frequency-dependent Plasticity For the Formation Of Audit...mentioning

confidence: 99%

Frequency-Dependent Plasticity in the Temporal Association Cortex Originates from the Primary Auditory Cortex, and Is Modified by the Secondary Auditory Cortex and the Medial Geniculate Body

Luo

Liu

et al. 2022

J. Neurosci.

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The brain areas that mediate the formation of auditory threat memory and perceptual decisions remain uncertain to date. Candidates include the primary (A1) and secondary (A2) auditory cortex, the medial division of the medial geniculate body (MGm), amygdala, and the temporal association cortex. We used chemogenetic and optogenetic manipulations with in vivo and in vitro patch-clamp recordings to assess the roles of these brain regions in threat memory learning in female mice. We found that conditioned sound (CS) frequency-dependent plasticity resulted in the formation of auditory threat memory in the temporal association cortex. This neural correlated auditory threat memory depended on CS frequency information from A1 glutamatergic subthreshold monosynaptic inputs, CS lateral inhibition from A2 glutamatergic disynaptic inputs, and nonfrequency-specific facilitation from MGm glutamatergic monosynaptic inputs. These results indicate that the A2 and MGm work together in an inhibitory-facilitative role.

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Section: Cs Frequency-dependent Plasticity For the Formation Of Audit...mentioning

confidence: 99%

Frequency-Dependent Plasticity in the Temporal Association Cortex Originates from the Primary Auditory Cortex, and Is Modified by the Secondary Auditory Cortex and the Medial Geniculate Body

Luo

Liu

et al. 2022

J. Neurosci.

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Parallel lemniscal and non-lemniscal sources control auditory responses in the orbitofrontal cortex (OFC)

Srivastava

Bandyopadhyay

2020

Preprint

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30The orbitofrontal cortex (OFC), controls flexible behavior through stimulus value updating 31 based on stimulus outcome associations, allowing seamless navigation in dynamic sensory 32 environments with changing contingencies. Sensory cue driven responses, primarily studied 33 through behavior, exist in the OFC. However, OFC neurons' sensory response properties, 34 particularly auditory, are unknown, in the mouse, a genetically tractable animal. We show that 35 mouse OFC single neurons have unique auditory response properties showing pure deviance 36 detection and long timescales of adaptation resulting in stimulus-history dependence. Further, 37 we show that OFC auditory responses are shaped by two parallel sources in the auditory 38 thalamus, lemniscal and non-lemniscal. The latter underlies a large component of the observed 39 deviance detection and additionally controls persistent activity in the OFC through the 40 amygdala. The deviant selectivity can serve as a signal for important changes in the auditory 41 environment. Such signals if coupled with persistent activity, obtained by disinhibitory control 42 from the non-lemniscal auditory thalamus or the amygdala, will allow for associations with a 43 delayed outcome related signal, like reward prediction error, and potentially forms the basis of 44 updating stimulus outcome associations in the OFC. Thus the baseline sensory responses allow 45 the behavioral requirement based response modification through relevant inputs from other 46 structures related to reward, punishment, or memory. Thus, alterations in these responses in 47 neurological disorders can lead to behavioral deficits.48 49 50 51 52 53 54Introduction: 55 The OFC, a part of the prefrontal cortex (PFC), is involved in flexible behaviour (Miller and 56 Cohen, 2001;Wallis, 2007; Fritz et al., 2010) by encoding specific stimulus-outcome or action-57 outcome expectancies as well as by dynamically revaluing such expectancies on the basis of 58 behavioural demands and motivational states (Delamater, 2007;Rudebeck et al., 2008; Wilson 59 et al., 2014; Fresno et al., 2019). Specific OFC circuits can control specific aspects of flexible 60 behaviour and multiple reinforcement learning processes (Lee et al., 2012; Groman et al., 61 2019). In order for OFC neurons to encode the sensory attributes and subjective value of 62 outcomes associated with external stimuli (Schoenbaum and Roesch, 2005; Delamater, 2007; 63 Ostlund and Balleine, 2007) it requires sensory inputs. It is known that sensory stimulus-64 evoked signals in the OFC can distinguish between appetitive and aversive outcomes (Morrison 65 and Salzman, 2011) associated with the stimuli. Further, the OFC also has the capacity to 66 influence sensory processing by modulating neuronal receptive fields in early sensory cortices, 67 particularly the auditory cortex (Winkowski et al., 2013). 68In order to understand how mechanistically specific stimulus outcome associations are created 69 and how the stimulus evoked OFC respon...

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Modulation of tonotopic ventral MGB is behaviorally relevant for speech recognition

Mihai

Moerel

Martino

et al. 2019

Preprint

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Impact statement: Ultra-high field neuroimaging dissects the ventral medial geniculate 17 body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that 18 vMGB top-down modulation is relevant for speech recognition. Abstract 23Sensory thalami are central sensory pathway stations for information processing. Their role for human 24 cognition and perception, however, remains unclear. Recent evidence suggests an involvement of the 25 sensory thalami in speech recognition. In particular, the auditory thalamus (medial geniculate body, MGB) 26 response is modulated by speech recognition tasks and the amount of this task-dependent modulation is 27 associated with speech recognition abilities. Here we tested the specific hypothesis that this behaviorally 28 relevant modulation is present in the MGB subsection that corresponds to the primary auditory pathway 29 (i.e., the ventral MGB [vMGB]). We used ultra-high field 7T fMRI to identify the vMGB, and found a 30 significant positive correlation between the amount of task-dependent modulation and the speech 31 recognition performance across participants within left vMGB, but not within the other MGB subsections. 32These results imply that modulation of thalamic driving input to the auditory cortex facilitates speech 33 recognition. 34

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Corrigendum: Direct Relay Pathways from Lemniscal Auditory Thalamus to Secondary Auditory Field in Mice

Cited by 3 publications

References 0 publications

Frequency-Dependent Plasticity in the Temporal Association Cortex Originates from the Primary Auditory Cortex, and Is Modified by the Secondary Auditory Cortex and the Medial Geniculate Body

Frequency-Dependent Plasticity in the Temporal Association Cortex Originates from the Primary Auditory Cortex, and Is Modified by the Secondary Auditory Cortex and the Medial Geniculate Body

Parallel lemniscal and non-lemniscal sources control auditory responses in the orbitofrontal cortex (OFC)

Modulation of tonotopic ventral MGB is behaviorally relevant for speech recognition

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