Corrigendum: Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

Coroniti, Roberta; Farjo, Rafal; Nuno, Didier; Ötvös, László; Scolaro, Laura; Surmacz, Eva

doi:10.3389/fmolb.2016.00075

Cited by 1 publication

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“…On the one hand, leptin was proved to enhance the bone mineral density, vascular cells calcification, arterial stiffness, and vascular calcification 24,25 . On the other hand, leptin was also proved leptin promotes the mobilization of vascular progenitor cells, vascular endothelial growth factor expressed, vascular endothelial growth factor expressed, and mediated neovascularization 26–29 . We found that leptin is negatively expressed in normal valves, but positively expressed in RHD valves.…”

Section: Discussionmentioning

confidence: 67%

“…24,25 On the other hand, leptin was also proved leptin promotes the mobilization of vascular progenitor cells, vascular endothelial growth factor expressed, vascular endothelial growth factor expressed, and mediated neovascularization. [26][27][28][29] We found that leptin is negatively expressed in normal valves, but positively expressed in RHD valves. The positive expression of leptin was found around the neovascularization.…”

Section: Immunohistochemical Resultsmentioning

confidence: 99%

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A new perspective: Fat tissue and adipokines in rheumatic heart valves

Xie

Zhang

et al. 2022

Journal of Cardiac Surgery

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Objective: To observe fat tissue and the expression of adipokines in rheumatic heart valves and explore the possible role of fat tissue and adipokines in the pathology of rheumatic heart disease (RHD). Methods: In this retrospective study, a total of 29 patients who received mitral valve replacement surgery were included. The study group consisted of 25 patients with RHD while the control group consisted of 4 patients with secondary mitral insufficiency caused by coronary heart disease (CAD). The clinical data of the patients including medical history, age, body mass index (BMI), fasting blood glucose (FBG), total triglycerides (TG), total cholesterol (TC), high-density lipoproteincholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein(a) [apo(a)], apolipoprotein(b) [apo(b)] were collected and compared. Cardiac ultrasonography was used to assess valve conditions before surgery. The removed valves were collected. The hematoxylin-eosin (HE) staining, oil-red O staining, andMasson's trichrome staining were adopted to evaluate the histological changes in the mitral valve. Immunohistochemical (IMC) staining was performed to evaluate the expression of adiponectin, leptin, and chemerin.Results: There was no significant difference in general information and blood lipid levels between the two groups (all p > .05). Preoperative ultrasonography showed adipose tissue in the mitral valve of RHD patients. In the study group, rheumatic mitral valve samples showed thickening, adherence at the junction of the leaflets, calcification, and yellowish or fat mass by naked observation. The HE staining showed that there was calcification, inflammatory cell infiltration, fibrous tissue arranged disorder, and neovascularization. The oil-red O staining suggested fatty infiltration. Masson's trichrome staining suggested disorderly arrangement of collagen fiber and elastic fiber in rheumatic lesions, and the lesions were dominated by collagen fiber hyperplasia and less elastic fiber

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Section: Discussionmentioning

confidence: 67%