Corrigendum: Cloning and Functional Characterization of Octβ2-Receptor and Tyr1-Receptor in the Chagas Disease Vector, Rhodnius prolixus

Hana, Sam; Lange, Angela B.

doi:10.3389/fphys.2020.00649

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…The availability of well-annotated genome information of model organisms, such as T. castaneum, provided an opportunity to study the functions of the octopaminergic signaling system. Octopamine receptors have been identified from many species, including B. mori [2,32], D. melanogaster [33], P. americana [34], A. mellifera [35], Bactrocera dorsalis [36], P. xylostella [26], and R. prolixus [24]. In the current study, we cloned an octopamine receptor from T. castaneum, and the phylogenetic analysis indicated that it belongs to the family of insect OctβRs, which are structurally similar to the vertebrate β-adrenergic receptors.…”

Section: Discussionmentioning

confidence: 72%

“…The Tyr2-Rs have been characterized in Drosophila and Bombyx mori. They are specifically activated by tyramine and selectively coupled to intracellular Ca 2+ mobilization but have no effect on intracellular cAMP concentration [21,23,24].…”

Section: Introductionmentioning

confidence: 99%

“…As a potential insecticide target, OctβRs have been studied for their pharmacological characterizations. The interaction of OctβRs on agonists and antagonists was tested in Plutella xylostella [26], B. mori [27], N. lugens [18], Rhodnius prolixus [24], and Nephotettix cincticeps [28].…”

Section: Introductionmentioning

confidence: 99%

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Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction of Tribolium castaneum

Zheng

Liu

et al. 2021

IJMS

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The neurohormone octopamine regulates many crucial physiological processes in insects and exerts its activity via typical G-protein coupled receptors. The roles of octopamine receptors in regulating behavior and physiology in Coleoptera (beetles) need better understanding. We used the red flour beetle, Tribolium castaneum, as a model species to study the contribution of the octopamine receptor to behavior and physiology. We cloned the cDNA of a β-adrenergic-like octopamine receptor (TcOctβ2R). This was heterologously expressed in human embryonic kidney (HEK) 293 cells and was demonstrated to be functional using an in vitro cyclic AMP assay. In an RNAi assay, injection of dsRNA demonstrated that TcOctβ2R modulates beetle locomotion, mating duration, and fertility. These data present some roles of the octopaminergic signaling system in T. castaneum. Our findings will also help to elucidate the potential functions of individual octopamine receptors in other insects.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction of Tribolium castaneum

Zheng

Liu

et al. 2021

IJMS

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“…Wang et al 2020;Deady and Sun 2015;Mattei et al 2015;Avila et al 2012;Orchard and Lange 1985;Lange 2009). Oa contributes to the regulation of most, if not all of these processes in Drosophila and other insect species (Kamhi et al 2017;Andreatta et al 2018;Orchard and Lange 1985;Lange 2009;Hana and Lange 2020;Wong and Lange 2014;Rezával et al 2012;Yoshinari et al 2020;White, Chen, and Wolfner 2021).…”

Section: Introductionmentioning

confidence: 99%

Drosophilacells that express octopamine receptors can either inhibit or promote oviposition

Rohrbach¹,

Knapp

Deshpande

et al. 2023

Preprint

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Adrenergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. InDrosophila, the ortholog of noradrenaline, octopamine (Oa), is required for ovulation as well as several other female reproductive processes. Loss of function studies using mutant alleles of receptors, transporters, and biosynthetic enzymes for Oa have led to a model in which disruption of octopaminergic pathways reduces egg laying. However, neither the complete expression pattern in the reproductive tract nor the role of most octopamine receptors in oviposition is known. We show that all six known Oa receptors are expressed in peripheral neurons at multiple sites within in the female fly reproductive tract as well as in non-neuronal cells within the sperm storage organs. The complex pattern of Oa receptor expression in the reproductive tract suggests the potential for influencing multiple regulatory pathways, including those known to inhibit egg-laying in unmated flies. Indeed, activation of some neurons that express Oa receptors inhibits oviposition, and neurons that express different subtypes of Oa receptor can affect different stages of egg laying. Stimulation of some Oa receptor expressing neurons (OaRNs) also induces contractions in lateral oviduct muscle and activation of non-neuronal cells in the sperm storage organs by Oa generates OAMB-dependent intracellular calcium release. Our results are consistent with a model in which adrenergic pathways play a variety of complex roles in the fly reproductive tract that includes both the stimulation and inhibition of oviposition.

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“…[6] The NLRP3 inflammasome is an intracellular protein complex that contains NLRP3, an apoptosis-associated speck-like protein containing a CARD domain (ASC) and cysteine protease pro-caspase-1. [7] In the CNS, NLRP3 inflammasome is considered necessary for initiating and activating the inflammatory response via recognizing dangerassociated molecular patterns (DAMPs). [8] Activated NLRP3 inflammasome initiate activation of caspase-1, which subsequently cleaves inflammatory pro-interleukin (IL)-1β and pro-IL-18 into their biologically active forms and consequently participates in pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes

Yao

Wang

Chen

et al. 2021

J Biochem & Molecular Tox

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Sodium houttuyfonate (SH) is a chemical compound synthesized by houttuynin and sodium bisulfite. As it has antinflammatory effects, SH has been widely used to treat autoimmune diseases, including post events following traumatic brain injury (TBI).Meanwhile, NOD-like receptor with pyrin domain containing-3 (NLRP3) inflammasomes in microglia may play a central role in TBI. But to date, the intracellular mechanisms involved in the anti-inflammatory effects of SH in TBI remain unknown, especially whether regulating NLRP3. To gain an insight into this possibility, we conducted cell culture and biochemical studies on the effect of SH on NLRP3 inflammasome in microglia. The results showed that SH inhibited TLR4 and NLRP3 inflammasome activation in the microglia cell. In parallel, phosphorylation of ERK and NF-κB p65, which play a key role in NLRP3 inflammasome formation, was decreased. Intraperitoneal injection of SH into TBI mice significantly reduced the modified neurological severity score (mNSS), as well as the degree of microglia apoptosis post-controlled cortical impact (CCI). Immunohistochemistry, Western blot analysis, and reverse-transcription polymerase chain reaction (RT-PCR) revealed that SH markedly reduced NLRP3 inflammasome activation, TLR4 activity, phosphorylation of ERK and NF-κB. Moreover, SH significantly inhibited microglia activation post-CCI, but effectively promoted the astrocyte activation and angiopoiesis.Taken together, our research provides evidence that SH attenuated neurological deficits post TBI through inhibiting NLRP3 inflammasome activation, via influencing the TLR4/NF-κB signaling pathway. These findings explain the intracellular mechanism of the anti-inflammatory activity caused by SH treatment following TBI.

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Corrigendum: Cloning and Functional Characterization of Octβ2-Receptor and Tyr1-Receptor in the Chagas Disease Vector, Rhodnius prolixus

Cited by 3 publications

References 14 publications

Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction of Tribolium castaneum

Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction of Tribolium castaneum

Drosophilacells that express octopamine receptors can either inhibit or promote oviposition

Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes

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