Corrigendum: Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children

Nizam, Rasheeba; Al-Ozairi, Ebaa; Goodson, J. Max; Melhem, Motesam; Davidsson, Lena; Alkhandari, Hessa; Madhoun, Ashraf Al; Shamsah, Sara; Qaddoumi, Malak; Alghanim, Ghazi; Alhasawi, Nouf; Abu‐Farha, Mohamed; Abubaker, Jehad; Shi, Peng; Hartman, Mor-Li; Tavares, Mary; Bitar, Milad S.; Ali, Hamad; Arefanian, Hossein; Devarajan, Sriraman; Al-Refaei, Faisal; Alsmadi, Osama; Tuomilehto, Jaakko; Al-Mulla, Fahd

doi:10.3389/fgene.2019.00221

Cited by 3 publications

(4 citation statements)

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“…Our search strategy ( Figure 1 and Methods section) identified 36 studies that met our inclusion criteria ( Bayoumi et al, 2007 ; Bayoumy et al, 2012 ; Boumaiza et al, 2012a ; Boumaiza et al, 2012b ; Ghattas et al, 2013 ; Mohamed Youssef et al, 2013 ; Zadjali et al, 2013 ; Ajjemami et al, 2014 ; Al-Daghri et al, 2014 ; Mackawy and Badawi, 2014 ; Youssef et al, 2014 ; Ajjemami et al, 2015 ; Mehanna et al, 2015 ; Alnory et al, 2016 ; Mehanna et al, 2016 ; Elouej et al, 2016a ; RaafatAbdRaboh et al, 2016 ; Elouej et al, 2016b ; Elouej et al, 2016c ; Khella et al, 2017 ; Hasan et al, 2017 ; Lakbakbi El Yaagoubi et al, 2017 ; Mackawy, 2017 ; Morjane et al, 2017 ; Ismail et al, 2019 ; Ibrahim and Bastawy, 2020 ; Salami and El Shamieh, 2019 ; ElGhareeb et al, 2019 ; Nizam et al, 2019 ; Boulenouar et al, 2019 ; Aljaibeji et al, 2020 ; Osman et al, 2020 ; Alenad et al, 2020 ; Hechmi et al, 2020 ; Kefi, 2021 ). In most cases, studies were excluded because they lacked detailed results, such as odds ratios, confidence intervals, and p -values.…”

Section: Resultsmentioning

confidence: 99%

“…There were several reasons for heterogeneity between these studies regarding MetS definitions, study populations, sample sizes, research design, and selection of the genetic markers ( Table 1 ). For example, while most of the studies focused on diverse populations, a few included only females in their research ( Mehanna et al, 2015 ; Morjane et al, 2017 ), and one study examined MetS in children ( Nizam et al, 2019 ). Similarly, the proportion of males and females, and the age range, varied in most studies; both of these factors are well-known sources of heterogeneity in meta-analyses ( Pei et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

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Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis

et al. 2021

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Background: The metabolic syndrome (MetS) is prevalent in Arabian populations. Several small-scale studies have been performed to investigate the genetic basis of MetS. This systematic review and meta-analysis aimed to examine whether candidate gene polymorphisms are associated with MetS susceptibility among ethnic groups of the Arabian world and to suggest possible directions for future research regarding genetic markers and MetS.Methods: A search was conducted for peer-reviewed articles that examined the genetic association of MetS in Arabian populations in the following databases: Medline, Embase, Scopus, Direct Science, Web of Science, ProQuest, and Google Scholar until March 31, 2021. Articles were eligible if they were case-control studies, which investigated MetS as a dichotomous outcome (MetS vs no MetS). To assess the quality of the studies, the Q-Genie tool (Quality of Genetic Association Studies) was used. A non-central chi2 (random-effect) distribution was used to determine the heterogeneity (H) of Q and I (Galassi et al., The American journal of medicine, 2006, 119, 812–819) statistics.Results: Our search strategy identified 36 studies that met our inclusion criteria. In most cases, studies were excluded due to a lack of statistical information such as odds ratios, confidence intervals, and p-values. According to the Q-Genie tool, 12 studies scored poorly (a score of≤35), 13 studies scored moderately ( >35 and≤45), and 12 studies had good quality ( >45 or higher). The most frequently studied genes were FTO and VDR (both included in four studies). Three SNPs indicated increased risk for MetS after calculating the pooled odds ratios: FTO-rs9939609 (odds ratio 1.49, 95% CI: 0.96–2.32); LEP-rs7799039 (odds ratio 1.85, 95% CI: 1.37–2.5); and SERPINA12-rs2236242 (odds ratio 1.65, 95% CI: 1.21–2.24). Meta-analysis studies showed no significant heterogeneity.Conclusion: There were many sources of heterogeneity in the study settings. Most of the studies had low to moderate quality because of sample size and power issues, not considering all potential sources of bias, and not providing details about genotyping methods and results. As most studies were small-scale, aimed to replicate findings from other populations, we did not find any unique genetic association between MetS and Arabian populations.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis

et al. 2021

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show abstract

“…Our search strategy (Figure 1 and Methods section) identified 36 studies that met our inclusion criteria (Bayoumi et al, 2007;Bayoumy et al, 2012;Boumaiza et al, 2012a;Boumaiza et al, 2012b;Ghattas et al, 2013;Mohamed Youssef et al, 2013;Zadjali et al, 2013;Ajjemami et al, 2014;Al-Daghri et al, 2014;Mackawy and Badawi, 2014;Youssef et al, 2014;Ajjemami et al, 2015;Mehanna et al, 2015;Alnory et al, 2016;Mehanna et al, 2016;Elouej et al, 2016a;RaafatAbdRaboh et al, 2016;Elouej et al, 2016b;Elouej et al, 2016c;Khella et al, 2017;Hasan et al, 2017;Lakbakbi El Yaagoubi et al, 2017;Mackawy, 2017;Morjane et al, 2017;Ismail et al, 2019;Ibrahim and Bastawy, 2020;Salami and El Shamieh, 2019;ElGhareeb et al, 2019;Nizam et al, 2019;Boulenouar et al, 2019;Aljaibeji et al, 2020;Osman et al, 2020;Alenad et al, 2020;Hechmi et al, 2020;Kefi, 2021). In most cases, studies were excluded because they lacked detailed results, such as odds ratios, confidence intervals, and p-values.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%