Corrigendum: A compliant and biomimetic three-layered vascular graft for small blood vessels (2017
                    <i>Biofabrication</i>
                    <b>9</b>
                    025010)

Zhang, Y; Li, X S; Guex, Anne Géraldine; Liu, S S; Müller, Eike; Malini, Riccardo Innocenti; Zhao, Haipeng; Rottmar, Markus; Maniura‐Weber, Katharina; Rossi, René M.; Spano, Fabrizio

doi:10.1088/1758-5090/aa730a

Cited by 5 publications

(3 citation statements)

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“…The stiffness of the vascular grafts was also analyzed by calculating the β-index, which is a parameter less dependent on blood pressure (Mackenzie et al, 2002) and, therefore, facilitates the comparison among the performance of different grafts reported in the literature. The β-index of all but the ElastinGraft-eL was much lower than that of the human saphenous vein (45 ± 12.5) (Zhang et al, 2017) and Dacron (67.8 ± 32.3) (Tai et al, 2000), and importantly, the ElastinGraft_eM's β-index (24.6 ± 0.64) matched that of the femoral artery (23.7 ± 0.8) (Emoto et al, 1998).…”

Section: Resultsmentioning

confidence: 98%

“…(c) Compliances of the different ElastinGrafts at low (50–90 mmHg), normal (80–120 mmHg), and high pressure (110–150 mmHg). (d) Comparison of stiffness (β-index) between the ElastinGrafts, native blood vessels [value of the human femoral artery taken from Emoto et al (1998) and value of the human saphenous vein taken from Zhang et al (2017)] and Dacron [value taken from Tai et al (2000)]. Values taken from literature are marked with an asterisk ( * ).…”

Section: Resultsmentioning

confidence: 99%

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Small Caliber Compliant Vascular Grafts Based on Elastin-Like Recombinamers for in situ Tissue Engineering

Fernández‐Colino

Wolf

Rütten

et al. 2019

Front. Bioeng. Biotechnol.

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Vascular disease is a leading cause of death worldwide, but surgical options are restricted by the limited availability of autologous vessels, and the suboptimal performance of prosthetic vascular grafts. This is especially evident for coronary artery by-pass grafts, whose small caliber is associated with a high occlusion propensity. Despite the potential of tissue-engineered grafts, compliance mismatch, dilatation, thrombus formation, and the lack of functional elastin are still major limitations leading to graft failure. This calls for advanced materials and fabrication schemes to achieve improved control on the grafts' properties and performance. Here, bioinspired materials and technical textile components are combined to create biohybrid cell-free implants for endogenous tissue regeneration. Clickable elastin-like recombinamers are processed to form an open macroporous 3D architecture to favor cell ingrowth, while being endowed with the non-thrombogenicity and the elastic behavior of the native elastin. The textile components (i.e., warp-knitted and electrospun meshes) are designed to confer suture retention, long-term structural stability, burst strength, and compliance. Notably, by controlling the electrospun layer's thickness, the compliance can be modulated over a wide range of values encompassing those of native vessels. The grafts support cell ingrowth, extracellular matrix deposition and endothelium development in vitro. Overall, the fabrication strategy results in promising off-the-shelf hemocompatible vascular implants for in situ tissue engineering by addressing the known limitations of bioartificial vessel substitutes.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Small Caliber Compliant Vascular Grafts Based on Elastin-Like Recombinamers for in situ Tissue Engineering

Fernández‐Colino

Wolf

Rütten

et al. 2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Fibrous vascular prostheses are fabricated to closely match natural blood vessel behavior. Electrospinning [ 44 , 45 , 46 , 47 ] and solution blow spinning [ 48 , 49 ] are most often used; these methods provide scaffolds with different fiber diameters and a high porosity, which are very good for substrates in terms of cell growth. Moreover, such materials are usually characterized by their high flexibility and breaking strength [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Cylindrical Polyurethane Scaffold Fabricated Using the Phase Inversion Method: Influence of Process Parameters on Scaffolds’ Morphology and Mechanical Properties

et al. 2021

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This work presents a method of obtaining cylindrical polymer structures with a given diameter (approx. 5 mm) using the phase inversion technique. As part of the work, the influence of process parameters (polymer hardness, polymer solution concentration, the composition of the non-solvent solution, process time) on the scaffolds’ morphology was investigated. Additionally, the influence of the addition of porogen on the scaffold’s mechanical properties was analyzed. It has been shown that the use of a 20% polymer solution of medium hardness (ChronoFlex C45D) and carrying out the process for 24 h in 0:100 water/ethanol leads to the achievement of repeatable structures with adequate flexibility. Among the three types of porogens tested (NaCl, hexane, polyvinyl alcohol), the most favorable results were obtained for 10% polyvinyl alcohol (PVA). The addition of PVA increases the range of pore diameters and the value of the mean pore diameter (9.6 ± 3.2 vs. 15.2 ± 6.4) while reducing the elasticity of the structure (Young modulus = 3.6 ± 1.5 MPa vs. 9.7 ± 4.3 MPa).

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Biodegradable Polymers as the Pivotal Player in the Design of Tissue Engineering Scaffolds

Zhang

King

2020

Adv Healthcare Materials

172

108

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Biodegradable polymers play a pivotal role in in situ tissue engineering. Utilizing various technologies, researchers have been able to fabricate 3D tissue engineering scaffolds using biodegradable polymers. They serve as temporary templates, providing physical and biochemical signals to the cells and determining the successful outcome of tissue remodeling. Furthermore, a biodegradable scaffold also presents the fourth dimension for tissue engineering, namely time. The properties of the biodegradable polymer change over time, presenting continuously changing features during the degradation process. These changes become more complicated when different materials are combined together to fabricate a composite or heterogeneous scaffold. This review undertakes a systematic analysis of the basic characteristics of biodegradable polymers and describe recent advances in making composite biodegradable scaffolds for in situ tissue engineering and regenerative medicine. The interaction between implanted biodegradable biomaterials and the in vivo environment are also discussed, including the properties and functional changes of the degradable scaffold, the local effect of degradation on the contiguous tissue and their evaluation using both in vitro and in vivo models.

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Corrigendum: A compliant and biomimetic three-layered vascular graft for small blood vessels (2017 Biofabrication 9 025010)

Cited by 5 publications

References 0 publications

Small Caliber Compliant Vascular Grafts Based on Elastin-Like Recombinamers for in situ Tissue Engineering

Small Caliber Compliant Vascular Grafts Based on Elastin-Like Recombinamers for in situ Tissue Engineering

Cylindrical Polyurethane Scaffold Fabricated Using the Phase Inversion Method: Influence of Process Parameters on Scaffolds’ Morphology and Mechanical Properties

Biodegradable Polymers as the Pivotal Player in the Design of Tissue Engineering Scaffolds

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