Corrigendum

Izutani, Yasuyuki; Yogosawa, Shingo; Sowa, Yoshihiro

doi:10.3892/ijo.2015.3315

Cited by 18 publications

(2 citation statements)

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“…Brassinin has been reported to induce G1 phase arrest through the increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in colorectal cancer cells [67]. The latest data suggests possible brassinin interference with the PI3K/Akt/mTOR/S6K1 signaling pathway [68].…”

Section: The Antiproliferative Effect Of Naturally Occurring Indolmentioning

confidence: 99%

Antiproliferative Effect of Indole Phytoalexins

2016

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Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities.

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Section: The Antiproliferative Effect Of Naturally Occurring Indolmentioning

confidence: 99%

Antiproliferative Effect of Indole Phytoalexins

2016

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“…These changes are attributed to the effects of Cx43 on the expression of loci that regulate the cell cycle [6,7]. For example, the expression levels of cell cycle-related proteins are reduced and the relative levels of cell cycle inhibitors (e.g., p21 and p27) are increased [8]. Some studies have shown that Cx43 plays an important role in the regulation of these genes [9].…”

Section: Discussionmentioning

confidence: 99%

Effects of Connexin43 Overexpression on U251 Cell Growth, Migration, and Apoptosis

Yu²,

Zhang

et al. 2017

Med Sci Monit

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BackgroundGlioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with a high incidence in adults. Connexin43 (Cx43) has general roles in tumorigenesis and is expressed in U251 glioma cells. Accordingly, the effects of Cx43 on the growth, migration, and apoptosis and the underlying mechanisms mediating Cx43-dependent migration and apoptosis were examined in U251 cells.Material/MethodsA Cx43-overexpressing U251 cell line was generated to analyze the effects of Cx43 overexpression on cell growth, wound healing, and apoptosis-related protein expression after treatment with temozolomide.ResultsThe growth rate of U251 cells overexpressing Cx43 was significantly lower than that of parental wild-type cells, and cell morphology was considerably altered. The expression level of Bcl-2 was higher and the expression levels of Bax and caspase-3 were lower in cells overexpressing Cx43 than in wild-type cells. Additionally, the Bax/Bcl-2 ratio decreased.ConclusionsCx43 inhibited the growth of U251 cells, promoted morphological changes and migration, and inhibited apoptosis via a mitochondria-associated pathway.

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Low-temperature Plasma Promotes Fibroblast Proliferation in Wound Healing by ROS-activated NF-κB Signaling Pathway

Xue-yin

Zhang

et al. 2018

CURR MED SCI

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Low-temperature plasma (LTP) has shown great promise in wound healing, although the underlying mechanism remains poorly understood. In the present study, an argon atmospheric pressure plasma jet was employed to treat L929 murine fibroblasts cultured in vitro and skin wounds in BALB/c mice. The in vitro analysis revealed that treatment of fibroblasts with LTP for 15 s resulted in a significant increase in cell proliferation, secretion of epidermal growth factor (EGF) and transforming growth factor-βi (TGF-βi), production of intracellular reactive oxygen species (ROS), and the percentage of cells in S phase, protein expression of phosphorylated p65 (P-p65) and cyclinD1, but a noted decrease in the protein expression of inhibitor kappa B (IκB). The in vitro experiments demonstrated that 30-s LTP treatment enhanced the number of fibroblasts and the ability of collagen synthesis, while 50-s treatment led to the opposite outcomes. These results suggested that LTP treatment promotes the fibroblast proliferation in wound healing by inducing the generation of ROS, upregulating the expression of P-p65, downregulating the expression of IκB, and activating the NF-κB signaling pathway and consequently altering cell cycle progression (increased DNA synthesis in S phage).

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Corrigendum

Cited by 18 publications

References 0 publications

Antiproliferative Effect of Indole Phytoalexins

Antiproliferative Effect of Indole Phytoalexins

Effects of Connexin43 Overexpression on U251 Cell Growth, Migration, and Apoptosis

Low-temperature Plasma Promotes Fibroblast Proliferation in Wound Healing by ROS-activated NF-κB Signaling Pathway

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