Corresponding type-specificity of vibriocidal and agglutinating activities ofVibrio choleraeantisera: relevance to vaccine immunogenicity

Abstract

SUMMARYCholera vibrios can be allocated to one of three biotypes (classical, intermediate and El Tor), each of which can be sub-divided into two serotypes (Ogawa and Inaba). Vibriocidal tests with absorbed antisera have shown no evidence of biotype specificity in the killing of bacteria, but they have confirmed the role of the two serotype-specific antigens in immunity to cholera. The same presence of serotype specificity, and absence of biotype specificity, has been found by bacterial agglutination, an easier and quicker serological test. The use of this simpler test in ensuring a balanced serotype response to cholera vaccine is discussed, together with evidence that may lead to the production of more effective vaccine and better immunity.

Cholera vaccines: the current status and problems

“…Antisera raised in rabbits showed that the Inaba serum displayed weaker vibriocidal activity compared to that produced by the Ogawa serum [86,136]. This agrees with the human response to cholera vaccines as a weaker Inaba vibriocidal response was detected in comparison to the Ogawa vibriocidal response [88,137].…”