Correspondence Between Objective and Subjective Reports of Adherence Among Adolescents With Acute Lymphoblastic Leukemia

Pai, Ahna L. H.; Drotar, Dennis; Kodish, Eric

doi:10.1080/02739610802151597

Cited by 19 publications

(24 citation statements)

References 18 publications

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“…Objective measures, including measurement of clinical outcomes, dose counts, pharmacy records, electronic monitoring of medication administration (e.g. the Medication Event Monitoring System, MEMS) and drug concentrations [18][19][20][21], seemingly provide the best measure of a patient's medication-taking behaviour in many contexts [22][23][24][25][26][27]. It is important to recognize that, while objective, most of these measures have drawbacks.…”

Section: Introductionmentioning

confidence: 99%

What are validated self-report adherence scales really measuring?: a systematic review

Nguyen

Caze

Cottrell

2014

Br J Clin Pharmacol

328

304

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AIMSMedication non-adherence is a significant health problem. There are numerous methods for measuring adherence, but no single method performs well on all criteria. The purpose of this systematic review is to (i) identify self-report medication adherence scales that have been correlated with comparison measures of medication-taking behaviour, (ii) assess how these scales measure adherence and (iii) explore how these adherence scales have been validated. METHODSCinahl and PubMed databases were used to search articles written in English on the development or validation of medication adherence scales dating to August 2012. The search terms used were medication adherence, medication non-adherence, medication compliance and names of each scale. Data such as barriers identified and validation comparison measures were extracted and compared. RESULTSSixty articles were included in the review, which consisted of 43 adherence scales. Adherence scales include items that either elicit information regarding the patient's medication-taking behaviour and/or attempts to identify barriers to good medication-taking behaviour or beliefs associated with adherence. The validation strategies employed depended on whether the focus of the scale was to measure medication-taking behaviour or identify barriers or beliefs. CONCLUSIONSSupporting patients to be adherent requires information on their medication-taking behaviour, barriers to adherence and beliefs about medicines. Adherence scales have the potential to explore these aspects of adherence, but currently there has been a greater focus on measuring medication-taking behaviour. Selecting the 'right' adherence scale(s) requires consideration of what needs to be measured and how (and in whom) the scale has been validated.

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Section: Introductionmentioning

confidence: 99%

What are validated self-report adherence scales really measuring?: a systematic review

Nguyen

Caze

Cottrell

2014

Br J Clin Pharmacol

328

304

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“…It may be that reported rates of adolescent adherence are higher than actual rates of treatment adherence due to social desirability. However, prior studies on adolescents with cancer have demonstrated that objective and self-report data on adherence are highly consistent (Kennard et al, 2004; Pai et al, 2008; Tebbi, 1993; Tebbi et al, 1986). Also, due to restricted range and high rates of perfect adherence, adolescent adherence was dichotomized for the analyses.…”

Section: Discussionmentioning

confidence: 96%

Medical and Psychosocial Associates of Nonadherence in Adolescents With Cancer

Hullmann

Brumley

Schwartz

2014

J Pediatr Oncol Nurs

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The current study examined adherence to medication regimens among adolescents with cancer by applying the Pediatric Self-Management Model. Adolescents and their parents reported on adherence to medication, reasons for nonadherence, and patient-, family-, and community-level psychosocial variables. Adolescent- and parent-reported adherence were significantly correlated, with about half of the sample reporting perfect adherence. The majority reported “just forgot” as the most common reason for missed medication. Patient-, family-, and community-level variables were examined as predictors of adherence. With regard to individual factors, adolescents who endorsed perfect adherence reported a greater proportion of future-orientated goals and spent fewer days in outpatient clinic visits. For family factors, adolescents who endorsed perfect adherence reported greater social support from their family and were more likely to have a second caregiver who they perceived as overprotective. The community-level variable (social support from friends) tested did not emerge as a predictor of adherence. The results of this study provide direction for intervention efforts to target adolescent goals and family support in order to increase adolescent adherence to cancer treatment regimens.

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“…For children and adolescents with leukemia or lymphoma who are prescribed two doses of 6MP per day, adherence decreases as rapidly as 6% per day, with rates falling as much as 40% over time . As children enter adolescence, the variability in the timing of medication administration often increases and nonadherence becomes even more prevalent . To capture the anticipated changes in medication adherence over time, providers are encouraged to assess and monitor medication adherence at each follow‐up outpatient clinic visit.…”

Section: Discussionmentioning

confidence: 99%

Assessing Medication Adherence as a Standard of Care in Pediatric Oncology

Pai

McGrady

2015

Pediatric Blood & Cancer

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Poor adherence to pediatric cancer treatment protocols may prevent children and adolescents from realizing the potential benefits of therapy. This paper presents the evidence for a standard of care for supporting medication adherence. Databases were reviewed for articles examining adherence and including children and/or adolescents with cancer. Fourteen articles (i.e., qualitative, quantitative, review, and randomized clinical trials) were evaluated for rigor.There is moderate-quality evidence to support a strong recommendation for adherence to be assessed routinely and monitored throughout the treatment. Integrating the proposed clinical procedures into standard clinical care may improve outcomes for children and adolescents with cancer. Pediatr Blood Cancer 2015;62:S818-S828. C 2015 Wiley Periodicals, Inc.

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Correspondence Between Objective and Subjective Reports of Adherence Among Adolescents With Acute Lymphoblastic Leukemia

Cited by 19 publications

References 18 publications

What are validated self-report adherence scales really measuring?: a systematic review

What are validated self-report adherence scales really measuring?: a systematic review

Medical and Psychosocial Associates of Nonadherence in Adolescents With Cancer

Assessing Medication Adherence as a Standard of Care in Pediatric Oncology

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