Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

Analysis of the Human Salivary Peptidome by Differential Peptide Display and LC-MS/MS Overview Sequencing

“…Saliva is also easy to store and transport and in contrast to blood there are minimal collection-associated risks. The search of dynamic marker for rheumatic disease like Sjögren's syndrome [6] found with the proteome of whole saliva an interesting field of action [7][8][9]. The proteome of saliva has been investigated by numerous researchers over the last decades and around 1400 distinct precursor proteins were identified [10].…”

Integrated Omics Analysis of Sjogren’s Syndrome

“…Rigante et al performed the proteomic analysis of the salivary peptide complex in SS patients' salivary uid near diagnosis and a er 6 months of pharmacological therapy. e analysis revealed that clinical and functional changes of the salivary glands driven by non-steroidal antin ammatory drugs might be re ected in di erent proteomic patterns of the salivary uid [17]. Using a proteomic approach, Giustil et al characterized the WS proteins of primary SS patients and revealed a set of di erentially expressed proteins in patients with primary SS, which are related to acute and chronic in ammation while some others were involved in oxidative stress injury.…”