Correspondence

Bidat, É.; Leneveu, A; Aegerter, Philippe; Roux, A; Flouvat, B; Gallet, Jean-Paul; Newcomb, Richard W.; Akhter, Javeed

doi:10.1002/ppul.1950080114

Cited by 2 publications

(1 citation statement)

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“…Slow-release theophylline is also a common means of maintaining good control of asthma in children. Good correlation (r = 0.99) has been reported for two methods of measuring theophylline, an immunoenzymatic technique and a gas chromatographic method [5]. The therapeutic level of the drug in plasma is between 5 and 151xgmL 1.…”

Section: Introductionmentioning

confidence: 89%

Comparison of isotopic dilution methods for determination of theophylline in the plasma and saliva of infants and children

Culea¹,

Palibroda

Cherecheş-Panţa³

et al. 2001

Chromatographia

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Isotope-dilution mass spectrometry (IDMS) using the direct inlet probe and an isotope dilution gas chromatographic-mass spectrometric (GC-IDMS) technique are presented for determination oftheophylline in paired specimens of plasma and saliva from infants and children treated with theophylline for idiopathic apnea of prematurity, or for asthma, lSN-theophylline was used as internal standard. A non-invasive means of individualization of the dosage was achieved by analysis of levels of the drug in saliva secreted in response to stimulation with citric acid.There was good correlation (r = 0.99) bek, veen results from the I",,vo different methods of analysis, which employed k, vo different mass spectrometers, the MAT 311 and HP 5989B, both in SIM mode. Good correlation was also observed bef,,veen plasma and saliva determinations (r = 0.97) and bel',,veen l',,vo methods of calculation, one using the regression curve and the other the least squares approach (r = 0.998). Applications to infants and children are clescribed.

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Section: Introductionmentioning

confidence: 89%