Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray μCT

Østergaard, Maja; Naver, Estrid Buhl; Schüpbach, Delia; Kaestner, Anders; Strobl, Markus; Brüel, Annemarie; Thomsen, Jesper Skovhus; Schmidt, Søren; Poulsen, Henning Friis; Kuhn, Luise Theil; Birkedal, Henrik

doi:10.1016/j.bone.2023.116837

Bone

2023

DOI: 10.1016/j.bone.2023.116837

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Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray μCT

Maja Østergaard,

Estrid Buhl Naver,

Delia Schüpbach

et al.

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2024

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Cited by 2 publications

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Phase-contrast neutron imaging compared with wave propagation and McStas simulations

Naver,

Bertelsen,

Østergaard

et al. 2024

J Appl Cryst

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Propagation-based phase contrast, for example in the form of edge enhancement contrast, is well established within X-ray imaging but is not widely used in neutron imaging. This technique can help increase the contrast of low-attenuation samples but may confuse quantitative absorption measurements. Therefore, it is important to understand the experimental parameters that cause and amplify or dampen this effect in order to optimize future experiments properly. Two simulation approaches have been investigated, a wave-based simulation and a particle-based simulation conducted in McStas [Willendrup & Lefmann (2020). J. Neutron Res. 22, 1–16], and they are compared with experimental data. The experiment was done on a sample of metal foils with weakly and strongly neutron absorbing layers, which were measured while varying the rotation angle and propagation distance from the sample. The experimental data show multiple signals: attenuation, phase contrast and reflection. The wave model reproduces the sample attenuation and the phase peaks but it does not reproduce the behavior of these peaks as a function of rotation angle. The McStas simulation agrees better with the experimental data, as it reproduces attenuation, phase peaks and reflection, as well as the change in these signals as a function of rotation angle and distance. This suggests that the McStas simulation approach, where the particle description of the neutron facilitates the incorporation of multiple effects, is the most convenient way of modeling edge enhancement in neutron imaging.

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Phase-contrast neutron imaging compared with wave propagation and McStas simulations

Naver,

Bertelsen,

Østergaard

et al. 2024

J Appl Cryst

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Crossing length scales: X-ray approaches to studying the structure of biological materials

Grünewald,

Liebi,

Birkedal

2024

IUCrJ

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Biological materials have outstanding properties. With ease, challenging mechanical, optical or electrical properties are realised from comparatively `humble' building blocks. The key strategy to realise these properties is through extensive hierarchical structuring of the material from the millimetre to the nanometre scale in 3D. Though hierarchical structuring in biological materials has long been recognized, the 3D characterization of such structures remains a challenge. To understand the behaviour of materials, multimodal and multi-scale characterization approaches are needed. In this review, we outline current X-ray analysis approaches using the structures of bone and shells as examples. We show how recent advances have aided our understanding of hierarchical structures and their functions, and how these could be exploited for future research directions. We also discuss current roadblocks including radiation damage, data quantity and sample preparation, as well as strategies to address them.

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Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray μCT

Cited by 2 publications

References 40 publications

Phase-contrast neutron imaging compared with wave propagation and McStas simulations

Phase-contrast neutron imaging compared with wave propagation and McStas simulations

Crossing length scales: X-ray approaches to studying the structure of biological materials

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