Correlative study of cytological features in grading of invasive breast carcinoma

Sinha, Anamika; Gill, SS

doi:10.4103/joc.joc_2_18

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…A statistically significant correlation between the cytological and histological grade with a Spearman correlation coefficient r= 0.831 and P value of <0.001. Similar to studies done by Sinha A et al [3] (r=0.97, p <0.01) and Pal S et al [19] (r=0.804, p-0.000).…”

Section: Discussionsupporting

confidence: 90%

“…Fine-needle aspiration cytology (FNAC) which is widely used for the diagnosis of breast malignancies before planned surgery, is used only to differentiate benign from malignant and the morphology of tumour. [3] The assessment of grading in cytology allows assessment of the tumor in situ which facilitates in deciding the most suitable treatment. Also, overtreatment of low-grade tumors can be avoided hence reduces the post treatment morbidity.…”

Section: Introductionmentioning

confidence: 99%

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Applicability of Cytological Grading of Carcinoma Breast

Pachori¹,

Chaturvedi²,

Pachori³

et al. 2021

Ann of Pathol and Lab Med

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Background: In India breast cancer incidence is on rise and large number of cases occur before 50 years of age. Early diagnosis and proper treatment are known to increase the survival of the patients. As fine needle aspiration cytology is widely used as a preliminary mode for the diagnosis of breast malignancies, adding a reliable grading system in reporting shall aid in planning the management options. Methods: It’s a prospective study done on 100 cases of breast malignancies from June 2018 to May 2020 in department of Pathology JLNMC, Ajmer. Cytology smears were stained with H&E and Geimsa and graded according to Robinson’s cytological grading system while their corresponding histopathological sections were stained with H&E and graded as per Elston and Ellis modification of Scarff Bloom & Richardson grading system and the results were compared. Result: Out of 100 cases of breast cancer evaluated in cytology 29% were grade I, 56% were grade II and 15% were grade III. On histopathological evaluation 25% were grade I, 54% were grade II while 21% were grade III. A highly significant association between the two grading systems was observed with coefficient of correlation 0.831, p value of <0.001 and concordance rate 80%. Conclusion: There is high degree of concordance between the Robinson’s and Elston and Ellis modification of Scarff Bloom & Richardson grading system. Robinson’s method is an easy and quick and reliable method to grade carcinomas of breast, hence it should be included in cytology reporting of breast carcinomas.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Applicability of Cytological Grading of Carcinoma Breast

Pachori¹,

Chaturvedi²,

Pachori³

et al. 2021

Ann of Pathol and Lab Med

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“…One of the reported study showed a statically significant association between cytologic and histologic grades (r=0.97; p<0.01) with sensitivity and specificity 100% and 93.95% respectively. [7] In another series of cases studied also showed good correlation of cytology and histopathological grading and substantial kappa value of agreement i.e. k=0.737 [8] .…”

Section: Discussionmentioning

confidence: 69%

Robinson’s cytological grading on fine needle aspirates (FNAC) of breast cancers and its correlation with histopathological grading

Deshmukh¹,

Khandelwal²,

Khaparde³

et al. 2020

Int. J. Clin. Diagn. Pathol.

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Background: Breast cancer is one of the most common cancers in females. Fine needle aspiration cytology plays an important role in the management of these patients. Aims and objectives: 1) To study Robinson's cytological grading on preoperative FNAC smears in cases of breast carcinoma. 2) To correlate Robinson's cytological grading with modified Scarff Bloom Richardson histopathological grading. Methods: A retrospective study was done on 50 patients of breast carcinoma over the period of 2 years from 1 st January 2018 to 31 st December 2019 at a tertiary care center. Results: Groups II and group III cases of breast carcinomas were correlated very well on cytological and histopathological grading. The sensitivity of cytological grading in the present study were 66.66%, 75% and 85.71 respectively. Specificity were 85%, 76.92% and 90.90% respectively i.e. maximum in grade III. The k value for present study showed 0.62 i.e substantial agreement. Conclusion: Cytological grading of breast carcinomas is a useful prognostic marker in the management of breast carcinoma. It is helpful in selecting the patients for modified radical mastectomy with axillary dissection and neoadjuvant chemotherapy.

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“…Data from surgical specimens were included in the study according to Pathological staging based on recommendations from AJCC 2018 (edition VIII) for TNM classification [ 14 ] and according to the Nottingham Histologic Score system [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

The real-word impact of breast and colorectal cancer surgery during the SARS-CoV-2 pandemic

et al. 2022

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The postponing of screening and the health care system reorganization, due to the Covid-19 pandemic and lockdown, could led to a concerning decline in breast and colorectal cancer diagnoses. This monocentric retrospective analysis has compared the pre-Covid period (March 2019 to March 2020) to the Covid period (April 2020 to April 2021) in terms of screening programs, clinical, surgical and pathological. A total of 799 patients diagnosed with Breast Cancer (BC) and Colorectal Cancer (CRC) underwent surgery during the two periods. In FVG in 2020 a decrease in mammography screening of 17.1% has been registered compared to 2019; this reduction has been higher for CRC screening, which summed up to 24.5%. As far as BC is concerned, screening-detected tumours rose significantly from 18 to 28%, mastectomies decreased from 40 to 31% and advanced tumours treated surgically decreased from 12 to 6%. Concerning CRC, a significant increase in admissions through the Emergency Department has been registered in spite of a stable percentage of urgent surgery performed, proving that severely symptomatic patients have been treated adequately. Open surgery has significantly decreased, whereas the tumoral stage and complications have remained constant in the two periods. This study has proved that maintaining standards of care and validated protocols during emergency is the most adequate and winning strategy: impact on BC and CRC has been less important than expected. These results support the recommendations for immediate and rapid screening program resumption at operating speed, using prioritization strategies to make up for the diagnostic delays.

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Correlative study of cytological features in grading of invasive breast carcinoma

Cited by 5 publications

References 10 publications

Applicability of Cytological Grading of Carcinoma Breast

Applicability of Cytological Grading of Carcinoma Breast

Robinson’s cytological grading on fine needle aspirates (FNAC) of breast cancers and its correlation with histopathological grading

The real-word impact of breast and colorectal cancer surgery during the SARS-CoV-2 pandemic

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