Correlations With Satisfaction Measures in Men Treated With Phosphodiesterase Inhibitors for Erectile Dysfunction

Abstract

This literature review examined the relationship of erectile function to patient satisfaction. Published correlation coefficients ( r values) were sought between patient-reported outcomes (PROs; i.e., instruments/questionnaires) assessing erection or erectile function and PROs assessing individual sexual satisfaction, satisfaction in the context of the couple or relationship, or satisfaction with erection. The U.S. National Library of Medicine’s PubMed database was searched for English-language, randomized, double-blind, placebo-controlled trials of treatment with a phosphodiesterase type 5 inhibitor in men with erectile dysfunction (ED) who were not selected for any concomitant disease. Trials that reported correlations between an ED-specific and psychometrically validated PRO for an erection/erectile function concept and for a selected satisfaction concept were included. All correlations were positive, with almost all r values >" xbd="285" xhg="262" ybd="1530" yhg="1502"/>.50. The positive relationship between results on erection/erectile function PROs and results on satisfaction PROs is probably reinforced bidirectionally such that improved erection/erectile function improves satisfaction, which further improves erection and/or erectile function.

Impact of a First Treatment with Phosphodiesterase Inhibitors on Men and Partners’ Quality of Sexual Life: Results of a Prospective Study in Primary Care

“…Increased erection hardness could be the main parameter, leading to improved confidence . All results obtained at the end of the survey showed that increased erection hardness was correlated to significant improvement in self‐esteem, sexual and overall relationship, and overall satisfaction of the patient, in agreement with results of previous clinical trials .…”

Sexual Dysfunction and Gun Ownership in America: When Hard Data Meet a Limp Theory

“…According to Potts (2000, p.90), “the absence of—or difficulty in ‘achieving’ and ‘maintaining’— a robust ‘hard on’ in appropriate circumstances presents as a disastrous affliction in the male—an abnormality, a failure to stand up and be counted as a ‘real’ man.” In this context, many men experiencing erectile dysfunction (ED) never seek treatment for their condition, and those men who do often wait until their symptoms become too severe to ignore (Burns & Mahalik, 2007; Sand et al, 2008e). When men are willing to seek help, they are sufficiently motivated by their distress to entertain a wide range of potential treatments, including changes in diet and exercise, smoking cessation, cutting alcohol and drug use, periodontal treatment, herbs (e.g., red ginseng), acupuncture, natural hormones (e.g., DHEA) and amino acids (e.g., L-arginine), psychological counseling, prescription medications (e.g., Viagra), urethral suppositories, topical creams, testosterone replacement therapy, vacuum pumps, penile injection therapy, external penile prostheses, penile implants, vascular reconstructive surgery, stem cell therapy, platelet-rich plasma therapy, penile shockwave therapy, and penile transplants (Brubaker & Johnson, 2008; Burnett et al, 2020; Dong et al, 2019; Efesoy et al, 2018; Farook et al, 2021; Gurtner et al, 2017; Hatzimouratidis, 2007; Irfan et al, 2020; Ismail et al, 2019; Lau et al, 2008; Li et al, 2017, 2019; Mulhall et al, 2011; Punjani et al, 2018; Raina et al, 2007; Tsai et al, 2017; Ulloa et al, 2008; Walther et al, 2017; Wentzell et al, 2017).…”

Rare and very rare adverse effects of clozapine

“…Regular goserelin acetate administration is the pharmacological treatment of choice in patients with recurrent priapism due to its antagonistic action on testosterone plasma levels. 61 …”