Correlations of unique clinical, immunotypic, and histologic findings in cutaneous gamma/delta T-cell lymphoma

Heald, Peter; Buckley, Patrick J.; Gilliam, Anita C.; Pérez, M.; Knobler, Robert; Kacinski, Barry M.; Rl, Edelson

doi:10.1016/0190-9622(92)70125-y

Cited by 35 publications

(11 citation statements)

References 12 publications

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“…One case (sf lethal midline granuloma which expressed T C R $6 was reported by Gaulard et al (1990). Four cases of primary cutaneous $6 T-cell lymphoma, presenting as multiple skin lesions without involvement of lymph node, liver, or spleen, were also reported recently (Berti et al, 1991;Heald et al, 1992;Wilhelm et al, 1992;Fujita et al, 1993). N o cytogenetic data are available on these cases.…”

Section: Resultsmentioning

confidence: 65%

Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity

Wang

Tien

Lin

et al. 1995

Genes Chromosomes & Cancer

109

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Peripheral T-cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the gamma/delta T-cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T gamma/delta cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T gamma/delta PTL.

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Section: Resultsmentioning

confidence: 65%

Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity

Wang

Tien

Lin

et al. 1995

Genes Chromosomes & Cancer

109

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“…Virtually all cases of γδ T‐cell lymphomas characterized by primary involvement of the skin, can easily be classified in either of two major categories: subcutaneous panniculitis‐like γδ T‐cell lymphoma 86 , 113 –117 or mycosis fungoides‐like cutaneous γδ T‐cell lymphoma 86 ,. 115 , 118 –122 …”

Section: γδ T‐cell Lymphomas Occurring In Other Sitesmentioning

confidence: 99%

γδ T‐cell lymphomas: a homogeneous entity?

Wolf‐Peeters

Achten

2000

Histopathology

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gammadelta T-cells comprise an immunologically distinct lymphoid population, characterized by specific morphological, phenotypical and functional properties. Therefore it seems reasonable to speculate that neoplasms derived from this particular T-cell subset display distinct features. Indeed, the prototype gammadelta T-cell lymphoma, hepatosplenic T-cell lymphoma constitutes a unique clinicopathological entitity which is intimately associated with a gammadelta T-cell phenotype. However, gammadelta T-cell lymphomas have also been described in other extranodal sites where, unlike reactive gammadelta T-cells and hepatosplenic gammadelta T-cell lymphomas, they display an important morphological heterogeneity. Moreover, these nonhepatosplenic gammadelta T-cell lymphomas are essentially not that different from their alphabeta T-cell receptor for antigen (TCR)-expressing counterparts and thus may be incorporated in the established T-cell lymphoma subclasses. However, subtle differences regarding their histopathological appearance as well as their biological behaviour indicate that further studies to determine the exact significance of TCR expression are required. Such inquiries may contribute to the general understanding of T-cell lymphomagenesis in general, which is still obscure.

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“…In humans, recent data suggest that some cases of Pagetoid reticulosis represent a cutaneous malignancy that originates from gamma/delta T lymphocytes (Berti et al 1991;Heald et al 1992). In these canine cases, the expression of ICAM-1 on keratinocytes and LFA-l on lymphocytes was minimal or absent despite lymphocyte epidermotropism.…”

Section: Discussionmentioning

confidence: 98%

Investigation of epidermotropism in canine mycosis fungoides: Expression of intercellular adhesion molecule-1 (ICAM-1) and beta-2 integrins

et al. 1995

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In human mycosis fungoides (MF), interactions between LFA-1 (CD11a/CD18) and ICAM-1 (CD54) are involved in lymphocyte adhesion to keratinocytes. The purpose of this study was to evaluate the expression of ICAM-1, beta-2 integrins and class II major histocompatibility complex molecules (MHC II) on keratinocytes and infiltrating lymphocytes in canine MF. Sections of frozen skin biopsy specimens from normal dogs (n = 3) and dogs with MF (n = 17) were evaluated by immunohistochemistry for expression of ICAM-1, beta-2 integrins, and class II MHC molecules. Our results demonstrated that in canine MF, ICAM-1 was expressed variably on epidermal and follicular keratinocytes. The extent of keratinocyte ICAM-1 expression did not correlate with the degree of lymphocyte epithelial infiltration, nor with lymphocyte LFA-1 expression. This was especially evident in cases of Pagetoid reticulosis-like disease in which prominent lymphocyte epidermotropism was not accompanied by keratinocyte ICAM-1 expression. Keratinocyte class II MHC molecule expression did not correlate with keratinocyte ICAM-1 expression. In conclusion, in canine MF, the lack of statistically significant correlations between epithelial lymphocyte infiltration and keratinocyte ICAM-1 expression, and between keratinocyte ICAM-1 and lymphocyte LFA-1 staining, suggests that the LFA-1/ICAM-1 pathway is not the major adhesion mechanism between lymphocytes and keratinocytes. It is suspected that different ligands of the LFA-1 integrin (e.g. ICAM-2) or other adhesion molecules (e.g. CD2/LFA-3, VLA-1) might be involved in the epitheliotropism phenomenon in canine MF. These hypothesis cannot be evaluated in the dog at this time owing to the lack of specific monoclonal antibodies.

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Correlations of unique clinical, immunotypic, and histologic findings in cutaneous gamma/delta T-cell lymphoma

Cited by 35 publications

References 12 publications

Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity

Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity

γδ T‐cell lymphomas: a homogeneous entity?

Investigation of epidermotropism in canine mycosis fungoides: Expression of intercellular adhesion molecule-1 (ICAM-1) and beta-2 integrins

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