Correlations of Leukotriene B4 and 25-Hydroxyvitamin D3 Levels with Disease Severity in Children with Henoch-Schonlein Purpura

Zhu, Lin; Zhang, Chunzhen; Xiang, Rongmei; Luo, Yan

doi:10.7754/clin.lab.2021.211030

Cited by 5 publications

(6 citation statements)

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“…In our study, 25-hydroxyvitamin D3 [25(OH)D3] levels decreased in children with relapses suggesting predictive values for prognosis and manifestation of another episode of HSPN. This finding aligns with conclusions made by Zhu L et al [ 31 ].…”

Section: Discussionsupporting

confidence: 94%

Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

Mukanhaire,

Ren,

Liu

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 94%

Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

Mukanhaire,

Ren,

Liu

et al. 2023

Heliyon

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“…In this study, we showed that compared to the healthy control population, children with IgA vasculitis have decreased 25(OH)D levels, which is in line with the findings of previous trials ( 19 - 21 ). The immune effects of vitamin D have been studied extensively.…”

Section: Discussionsupporting

confidence: 91%

“…Reports have shown that patients with SLE have significantly insufficient vitamin D levels ( 13 ), as do those with other immune diseases, such as multiple sclerosis ( 14 ), autoimmune thyroid disorders ( 15 ), and antiphospholipid syndrome ( 16 ). There is increasing evidence that IgA vasculitis patients also have lower serum levels of vitamin D than healthy children, but most of these previous studies had small sample sizes ( 19 - 21 ). Thus, an observational retrospective study was conducted with a large sample size to compare vitamin D levels between children with IgA vasculitis and healthy children.…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, while vitamin D has been widely studied in autoimmune diseases, few studies have investigated the role of vitamin D in IgA vasculitis patients. At present, only a few studies with small sample sizes have shown that IgA vasculitis patients have lower vitamin D levels than healthy controls ( 19 - 21 ). The distribution of vitamin D levels in renal involvement, gastrointestinal involvement, and joint involvement has not been thoroughly studied.…”

Section: Introductionmentioning

confidence: 96%

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The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

Wang¹,

Ye²

2023

Transl Pediatr

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Background IgA vasculitis is the most common form of vasculitis in children. Vitamin D deficiency has been observed to contribute to immune function and the pathogenesis of various immune diseases. However, at present, only a few studies with small sample sizes have shown that IgA vasculitis patients have lower vitamin D levels than healthy children. Thus, we conduct a large study to investigate the significance of serum 25-hydroxyvitamin D3 (25(OH)D) levels of children with IgA vasculitis across different subgroups and healthy children. Methods In this retrospective study, 1,063 children were recruited from the Ningbo Women and Children’s Hospital between February 2017 and October 2019, including 663 patients hospitalized with IgA vasculitis and 400 healthy examination children who served as the control group at the same time. There wasn’t any bias in the season. The healthy group came from children who underwent normal physical examination. The 663 IgA vasculitis patients were then divided into the IgA vasculitis-nephritis and non-IgA vasculitis-nephritis groups, streptococcal-infection and no-streptococcal-infection groups, gastrointestinal-involvement and no-gastrointestinal-involvement groups, and joint-involvement and no-joint-involvement groups. The serum 25(OH)D levels at disease onset were analyzed. All the participants were followed up for 6 months from the date of onset. Results The serum 25(OH)D levels of the IgA vasculitis group (15.47±6.58 ng/mL) were significantly lower than those of the healthy control group (22.48±6.24 ng/mL) (P<0.01). There were no significant differences in terms of age and sex between the IgA vasculitis and healthy control group. Further, among the IgA vasculitis patients serum 25(OH)D levels were reduced in the IgA vasculitis-nephritis (12.99±4.92 ng/mL), streptococcal-infection (14.2±6.06 ng/mL), and gastrointestinal-involvement (14.43±6.33 ng/mL) groups (P=0.00, 0.004, 0.002, respectively). The vitamin D levels with IgA vasculitis were significantly lower in winter and spring than summer and autumn. Conversely, the joint-involvement group did not show a significant reduction in vitamin D levels compared to no joints involved group. Conclusions IgA vasculitis patients have reduced vitamin D levels, which suggests that vitamin D deficiency may be involved in the development of IgA vasculitis. Vitamin D supplementation may reduce the incidence of IgA vasculitis, and maintaining high vitamin D levels in IgA vasculitis patients may prevent renal damage.

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“…These processes collectively contribute to developing IgA vasculitis by initiating and amplifying the inflammatory response within the vascular wall. Recent studies have consistently demonstrated a significant association between disease progression in IgAV and increased CRP levels ( 53 , 54 ). Interestingly, a study investigated IgAV patients with MEFV mutations and found that those without genetic mutations significantly increased CRP levels, which correlated significantly with increased serum IgA concentrations.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study

Qin,

Zhang,

et al. 2023

Front. Immunol.

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BackgroundIgA vasculitis (IgAV) is an immune-associated vasculitis, yet its exact etiology remains unclear. Here, we explore the interaction between IgAV and inflammatory factors using bidirectional Mendelian randomization (MR).MethodsWe conducted a bidirectional summary-level MR analysis to delineate the causality of C-reactive protein (CRP), procalcitonin (PCT), and 41 circulating inflammatory regulators with IgAV. Data on genetic variants related to inflammation were obtained from three genome-wide association studies (GWASs) on CRP, PCT, and human cytokines, whereas data on IgAV was from large meta-analyses of GWAS among 216 569 FinnGen Biobank participants. The primary MR analysis was performed using the inverse-variance weighted (IVW) approach, and the sensitivity analyses were carried out using MR-Egger, weighted median, weighted mode, and MR-pleiotropy residual sum and outlier.ResultsThis study revealed the association of CRP higher levels with increased risk of IgAV through IVW method (Estimate odds ratio [OR] = 1.41, 95% confidence interval [CI]: 1.01-1.98, P = 0.04), MR-Egger (OR = 1.87, CI: 1.15-3.02, P = 0.01), weighted median (OR = 2.00, CI: 1.21-3.30, P = 0.01) and weighted mode (OR = 1.74, CI: 1.13-2.68, P = 0.02). Furthermore, elevated IL-8 was strongly implicated with a higher risk of IgAV (IVW OR = 1.42, CI: 1.05-1.92; P = 0.02). Conversely, genetically predicted IgAV was associated with decreased levels of TNF-β (IVW estimate β = -0.093, CI: -0.178 - -0.007; P = 0.033). Additionally, no such significant statistical differences for other inflammatory factors were found.ConclusionOur current study using bidirectional MR analysis provides compelling evidence for a causal effect of CRP, PCT, and circulating inflammatory regulators on IgAV. These findings contribute to a better understanding of the pathogenesis of IgAV and emphasize the potential of targeting inflammatory factors for therapeutic interventions.

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Correlations of Leukotriene B4 and 25-Hydroxyvitamin D3 Levels with Disease Severity in Children with Henoch-Schonlein Purpura

Cited by 5 publications

References 0 publications

Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study

Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study

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