Correlations of Enzyme Levels at Birth in Stressed Neonates with Short-Term Outcomes

Nakajima, Junya; Tsutsumi, Norito; Nara, Shonosuke; Ishii, Hiroki; Suganami, Yusuke; Sunohara, Daisuke; Kawashima, Hisashi

doi:10.1080/15513815.2018.1458928

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…However, the changes in our study may be not obvious enough because the release of enzymes was also affected by uterine contractions and physical stress through the birth canal, while the small number of natural delivery were included [26]. The regulation of substances by hormones was equally important after birth, which can be demonstrated by bone metabolism status in neonates.…”

Section: Age-dependent Ris For 26 Common Biochemical Analytesmentioning

confidence: 86%

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Wang

Zhu

Zhou

et al. 2020

Preprint

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Background: Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates.Methods: A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analytes, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode.Results: There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphate, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significant different from adult and pediatric groups.Conclusions: RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

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Section: Age-dependent Ris For 26 Common Biochemical Analytesmentioning

confidence: 86%

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Wang

Zhu

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The differences in enzymes were considered the result of minor cell damage caused by physiological hypoxia during labour [31]. However, the changes in our study may be not obvious enough because the release of enzymes was also affected by uterine contractions and physical stress through the birth canal, while the small number of natural delivery were included [32]. The regulation of substances by hormones was equally important after birth, which can be demonstrated by bone metabolism status in neonates.…”

Section: Age-dependent Ris For 26 Common Biochemical Analytesmentioning

confidence: 85%

Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China

et al. 2021

View full text Add to dashboard Cite

Background Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates. Methods A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analyte, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode. Results There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphorus, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significantly different from adult and pediatric groups. Conclusions RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

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“…2 In asphyxiated newborns, initial LDH levels may be useful in predicting the severity of their illness and the subsequent duration of mechanical ventilation. 3 One study of 54 newborns stated that "LDH is an excellent predictor to differentiate RDS from TTN soon after birth in full-term neonates with respiratory distress". 4 We wanted to look at LDH levels in a larger group of RDS and TTN patients to assess its diagnostic value, as well as its possible predictive value in terms of the degree and duration of respiratory support requirement.…”

mentioning

confidence: 99%

Using lactate dehydrogenase to predict the severity of respiratory distress in term newborn infants with no perinatal asphyxia

Lee¹,

Lee²,

Bae³

et al. 2021

Turk J Pediatr

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Background. We aimed to establish whether knowledge of lactate dehydrogenase (LDH) levels on day 1, as well as the change in these levels in the first three days, could be of clinical benefit in the diagnosis and/or prediction of severity of respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN). Methods.A retrospective study was conducted on 275 term infants (35 with RDS and 240 with TTN) admitted to the neonatal intensive care unit from January 2014 to June 2019. LDH levels were measured on admission and after three days.Results. Both RDS and TTN groups had elevated LDH levels during admission. LDH levels were significantly higher in the RDS group than in the TTN group on both days. LDH levels in both groups significantly correlated with both the duration of respiratory support required, as well as the number of hospital days. We used these outcomes as a measure of severity of these conditions. Conclusions.In patients with respiratory distress, it may not be clinically useful to use LDH levels on day 1 to differentiate between RDS and TTN, despite the statistically significant differences, because of the overlapping values. However, LDH levels on day 1 and day 3 may predict the degree and duration of the required respiratory support for both RDS and TTN groups.

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Correlations of Enzyme Levels at Birth in Stressed Neonates with Short-Term Outcomes

Abstract: Initial enzyme levels are useful for predicting the duration of mechanical ventilation in stressed neonates.

Cited by 3 publications

References 11 publications

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China

Using lactate dehydrogenase to predict the severity of respiratory distress in term newborn infants with no perinatal asphyxia

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