Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis

Mouchet-Mages, Sabine; Rodrigo, S.; Cachia, Arnaud; Mouaffak, Fayçal; Olié, Jean‐Pierre; Méder, Jean-François; Oppenheim, Catherine; Krebs, Marie‐Odile

doi:10.1111/j.1600-0447.2010.01667.x

Cited by 60 publications

(46 citation statements)

References 53 publications

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“…In first-episode patients, impaired motor skills in a pegboard task were related to reduced fractional anisotropy in the anterior thalamic radiation and corticospinal tract [212]. Motor coordination was associated with white matter density in the left inferior frontal gyrus [150 ]and thalamus [154]. Furthermore, actigraphically assessed motor activity in schizophrenia was linked to white matter integrity underneath the SMA [92].…”

Section: Neurobiology Of the Motor System In Schizophreniamentioning

confidence: 99%

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Motor Symptoms and Schizophrenia

Walther¹,

Strik²

2012

Neuropsychobiology

299

233

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Classical schizophrenia literature reports motor symptoms as characteristic of the disorder. After the introduction of neuroleptic drugs, the existence of genuine motor disorders was challenged. Renewed interest arose as symptoms were found in never-medicated patients. Reports focused on abnormal involuntary movements, parkinsonism, neurological soft signs, catatonia, negative symptoms, or psychomotor slowing. Since these syndromes refer to different concepts, however, the definitions are not congruent and the symptoms overlap. The prevalence rates of motor symptoms in schizophrenia are surprisingly high, and recent studies indicate a possible pathobiology. In particular, the development and maturation of the human motor system appears to be closely linked to the emergence of motor symptoms observed in schizophrenia. Post-mortem and neuroimaging results demonstrated aberrant structure and function of premotor and motor cortices, basal ganglia, thalamus, and the connecting white matter tracts. Animal models have focused on aberrant neurotransmission and genetic contributions. Findings of localized abnormal oligodendrocyte function and myelination point to the special role of the white matter in schizophrenia, and recent studies specifically found an association between motor abnormalities and white matter structure in schizophrenia. This review of the literature supports the idea that motor symptoms are closely related to the neurodevelopmental disturbances of schizophrenia and a distinct syndromal dimension with its own pathophysiology.

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Section: Neurobiology Of the Motor System In Schizophreniamentioning

confidence: 99%

“…Indeed, motor deficits as a component of NSSs were found to be associated with gray matter loss in the motor cortices, caudate nucleus, and thalamus (see also online suppl. table 2) [150,151,152,153,154,155]. …”

Section: Neurobiology Of the Motor System In Schizophreniamentioning

confidence: 99%

Motor Symptoms and Schizophrenia

Walther¹,

Strik²

2012

Neuropsychobiology

299

233

View full text Add to dashboard Cite

show abstract

“…According to previous structural magnetic resonance imaging (MRI) studies, increased NSS scores were found to be related to atrophic processes within the caudate nucleus [7,11,12,13], putamen [7,14], globus pallidus [7,13], thalamus [7,11,12,13,15], cerebellum [12,16], inferior and middle frontal gyri [12], and corpus callosum [17]. Studies using functional MRI techniques reported abnormal activation in the pre- and postcentral gyrus, the premotor area, and the middle and inferior frontal gyri in patients with higher NSS scores [18,19].…”

Section: Introductionmentioning

confidence: 99%

Neurological Soft Signs and Brainstem Morphology in First-Episode Schizophrenia

Hirjak

Stieltjes²,

Hauser

et al. 2013

Neuropsychobiology

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Background: Minor motor and sensory deficits or neurological soft signs (NSS) have frequently been reported in patients with schizophrenia at any stage of their illness. NSS have been demonstrated to correlate with neuroanatomical abnormalities in various brain regions. Despite its important role in the integration and coordination of automatic motor actions, the brainstem has so far rather been ignored in previous neuroimaging studies on NSS in schizophrenia. Method: We investigated 21 right-handed first-episode schizophrenia patients using high-resolution magnetic resonance imaging at 3 T. The severity of NSS was measured with the Heidelberg Scale. Associations between NSS and both brainstem volume and shape changes were examined. Results: Higher NSS scores were significantly associated with structural alterations in the brainstem. According to volume measurements higher NSS scores correlated with global changes of the brainstem. Using shape analyses these associations referred to regionally specific morphometric alterations predominantly in the midbrain and pons. Conclusion: The findings suggest that brainstem morphometric alterations are associated with the severity of NSS in patients with first-episode schizophrenia. They further indicate the involvement of the brainstem in the pathogenesis of schizophrenia.

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“…Additionally, motor coordination deficits are negatively correlated with cerebellar white matter volume [11]. Furthermore, there have been found a significant inverse correlation between neurological soft signs scores (NSS) and right cerebellar hemisphere volume [12].…”

Section: Introductionmentioning

confidence: 87%

“…It has been shown that higher scores of motor coordination subscores of NSS are correlated negatively with white matter structure of the cerebellum. Also total NSS scores are associated with altered cerebello-thalamo-cortical network [11] and interestingly with mentioned right cerebellar hemisphere volume, involved in language processesing [39].…”

Section: Discussionmentioning

confidence: 99%

Relationship between cerebellar impairments and lexicon retrieval in schizophrenia - preliminary study

Chrobak¹,

Biela²,

Siuda³

et al. 2013

Arch Psych Psych

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SummaryAim of the study. Investigation of relationship between cerebellar motor dysfunctions and language impairments connected with cerebellum during phonological and semantic fluency tasks and verb generation task in schizophrenic patients and healthy control group. Subject or material and methods. 14 schizophrenic patients on olanzapine, clozapine or quetiapine treatment and 13 healthy volunteers were examined. Motor signs were assessed by using the International Co-operative Ataxia Rating Scale (ICARS). Phonological and semantic fluency tasks were performed. All of the words were recorded and counted. Results. Patients with schizophrenia revealed significantly higher ICARS mean score (12.21) than control group (3.92), and lower number of proper generated words in semantic fluency and verb generation tasks. Strong negative correlation (rs(13) = -0.71, p<0.01) was found between ICARS total score and number of proper answers in verb generation task. Discussion. Higher number of total ICARS score in schizophrenia patients in comparison to control group may suggest cerebellar impairments. There is disproportion between semantic and phonological fluency. Significant correlation between verb generation and cerebellar signs supports a hypothesis of cerebellum dysfunction during this task in schizophrenia patients. Conclusions. Schizophrenic patients reveal impairments which may be connected with the cerebellum. schizophrenia / verb generation / cerebellum / cognitive dysmetria

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Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis

Abstract: Structural alteration in the cerebello-thalamo-prefrontal network is associated with neurological soft signs in schizophrenia, a candidate network for 'cognitive dysmetria'.

Cited by 60 publications

References 53 publications

Motor Symptoms and Schizophrenia

Motor Symptoms and Schizophrenia

Neurological Soft Signs and Brainstem Morphology in First-Episode Schizophrenia

Relationship between cerebellar impairments and lexicon retrieval in schizophrenia - preliminary study

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