Correlations of attitudes toward antipsychotic drugs with insight and objective psychopathology in schizophrenia

Rocca, Paola; Crivelli, Barbara; Marino, Federica Zito; Mongini, Tullia; Portaleone, Francesca; Bogetto, Filippo

doi:10.1016/j.comppsych.2007.08.013

Cited by 46 publications

(51 citation statements)

References 52 publications

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“…In the current study, the score of DAI-10 had a significant relationship with medication compliance of patients at the time of investigation in which the finding was consistent with those of other studies (30,32,33). Moreover, many other studies showed a positive correlation between medication adherences and positive attitude towards medication (34,35).…”

Section: Discussionsupporting

confidence: 81%

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Shariati

Shabani

Arianakia

et al. 2018

Iran J Psychiatry Behav Sci

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Background: A negative attitude toward treatment is a major obstacle to treat bipolar disorder. Objectives: The current study aimed at assessing the reliability and validity of Persian version of drug attitude inventory (DAI-10) in patients with bipolar I disorder and finding its relationship with patients' compliance in order to predict the disorder. Methods: To assess test-retest reliability, 30 outpatients with bipolar I disorder were selected. They were asked to answer the questions at the onset of the study and four to ten days later. Then, the relationship between DAI-10 scores of 82 patients in bipolar disorder patients' follow-up (BDPF) study, and medication possession ratio (MPR) were investigated. The patients were divided into poor and good compliance, and cut off point of the tool was assigned. Positive and negative predictive value of DAI score was also calculated.

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Section: Discussionsupporting

confidence: 81%

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Shariati

Shabani

Arianakia

et al. 2018

Iran J Psychiatry Behav Sci

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“…Several studies have shown that a negative attitude toward medication was associated with the presence of symptoms [9,30] and global psychopathology [25,26,29,32]. But this study showed that drug attitude was not affected significantly by global psychopathology, as assessed by the CGIS Scale.…”

Section: Discussioncontrasting

confidence: 73%

Social Interaction and Drug Attitude Effectiveness in Patients with Schizophrenia

2011

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This study aimed to explore the relationship between dosage of paliperidone and drug attitude, and also clarify the factors associated with drug attitude, using Intention-to-Treat (ITT) analysis. Three hundred thirty-one patients diagnosed with schizophrenia, who prescribed paliperidone between April 2008 and April 2009, from 10 hospitals in Taiwan were enrolled. By structural equation modeling, inpatient/outpatient status associated with occupation status, sex, and score on the Clinical Global Impression-Severity (CGIS) Scale. The score on the Personal and Social Performance (PSP) Scale associated with occupation status, inpatient/outpatient status, and the score on the CGIS Scale. The scores on the DAI-10 associated with the score on the PSP Scale and age. Good drug attitude and medication adherence significantly related to good social interaction. We should enhance the drug attitude and medication adherence of patients with schizophrenia who have poor social interaction to improve the outcome of schizophrenia.

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“…12,13 Moreover, some research suggests that patients receiving atypical antipsychotics have more favorable subjective responses to their current medication than those receiving conventional medications. [14][15][16] However, other studies report no difference or suggest patient characteristics may be responsible for differences in adherence rather than type of medication. 17 The health belief model suggests that patient likelihood to continue with medication intake is a product of an implicit and subjective assessment of the relative risks and benefits of the medicine in relation to personal goals and constraints.)…”

Section: Introductionmentioning

confidence: 84%

“…This was unexpected, because numerous studies have identified positive symptom severity as the leading predictor of higher risk of discontinuation. [31][32][33][34][35] Moreover, patient compliance 36,37 and attitude toward medication 15 have been linked to PANSS positive subscale scores. However, the depressive symptom cluster has also been implicated as an important factor in both adherence 5,32,35 and attitude toward medication, 38 as have symptoms of hostility/excitement.…”

Section: Discussionmentioning

confidence: 99%

Patient perspectives on antipsychotic treatments and their association with clinical outcomes

Liu‐Seifert

Osuntokun²,

Godfrey³

et al. 2010

PPA

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This analysis examined patient-reported attitudes toward antipsychotic medication and the relationship of these attitudes with clinical outcomes and pharmacotherapy adherence. The analysis included three randomized, double-blind studies in patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition and randomly assigned to treatment with olanzapine 5-20 mg/day or another antipsychotic (haloperidol 2-20 mg/day, risperidone 2-10 mg/day, or ziprasidone 80-160 mg/day). Patient-reported improvements were significantly greater for olanzapine (n = 488) versus other treatments (haloperidol n = 145, risperidone n = 158, or ziprasidone n = 271) on multiple Drug Attitude Inventory items. A positive attitude toward medication reported by patients was significantly associated with greater clinical improvement on the Positive and Negative Syndrome Scale and lower discontinuation rates. These results suggest that patients' perceptions of treatment benefits are associated with objective clinical measures, including reduction of symptom severity and lower discontinuation rates. Furthermore, olanzapine may be associated with more positive treatment attitudes. These findings may contribute to a better understanding of reasons for treatment adherence from patients' own perspectives.

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Correlations of attitudes toward antipsychotic drugs with insight and objective psychopathology in schizophrenia

Cited by 46 publications

References 52 publications

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Social Interaction and Drug Attitude Effectiveness in Patients with Schizophrenia

Patient perspectives on antipsychotic treatments and their association with clinical outcomes

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