Correlations between vitronectin, miR-520, and miR-34 in patients with stenosis of coronary arteries

Shaikhnia, Farhad; Soleimani, Ali Akbar; Abkenar, Borhan Rahimi; Najafi, Mohammad

doi:10.1007/s11033-021-06821-z

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The activated endothelial cells might overexpress adhesion molecules and enhance leukocyte adhesion following rolling, strong adhesion, crawling, and transmigration processes [7]. Many studies showed that non-coding RNAs target the adhesion molecules and other genes involved in vessel stenosis [20][21][22][23][24]. This study was focused on the effects of miRNA-related genes predicted Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, macrophages by production of matrix metalloproteinase enzymes (MMPs) degrade the extracellular matrix (ECM), causing plaque remodeling [1-3, 5, 6]. In the other hand, micro-RNAs (miRNA/miR) are small nucleotides that affect the cellular pathways via the regulation of gene expression levels [13,20,21]. Many studies reported that micro-RNAs might retard atherosclerosis process by targeting some genes such as adhesion molecules [20,22].…”

Section: Open Accessmentioning

confidence: 99%

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miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach

et al. 2022

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Objective The endothelial cells overexpress the adhesion molecules in the leukocyte diapedesis pathway, developing vessel subendothelial molecular events. In this study, miR-194 and miR-27a were predicted and investigated on the expression of adhesion molecules in HUVEC cells. The SELE, SELP, and JAM-B adhesion molecules involved in the leukocyte tethering were predicted on the GO-enriched gene network. Following transfection of PEI-miRNA particles into HUVEC cells, the SELE, SELP, and JAM-B gene expression levels were evaluated by real-time qPCR. Furthermore, the monocyte-endothelial adhesion was performed using adhesion assay kit. Results In agreement with the prediction results, the cellular data showed that miR-27a and miR-194 decrease significantly the SELP and JAM-B expression levels in HUVECs (P < 0.05). Moreover, both the miRNAs suppressed the monocyte adhesion to endothelial cells. Since the miR-27a inhibited significantly the monocyte-endothelial adhesion (P = 0.0001) through the suppression of SELP and JAM-B thus it might relate to the leukocyte diapedesis pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach

et al. 2022

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“…ApoE, located in HDL, suppresses the expression of type VIII collagen, so that its decrease is associated with an increase in type VIII collagen [ 86 ]. HDL also reduces ox-LDL and TNF-α levels, and results in the reduction of endothelial cell apoptosis [ 92 , 93 ]. The macrocalcification also increases plaque consistency, while microcalcification makes plaque vulnerable.…”

Section: Recruiting Blood Cells Into Sub-endothelial Space Increases ...mentioning

confidence: 99%

Cellular crosstalk in atherosclerotic plaque microenvironment

Mahdinia,

Shokri,

Taheri

et al. 2023

Cell Commun Signal

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Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment, cell polarization, and cell fat droplets. It also describes cross talking between endothelial cells, macrophages, and vascular smooth muscle cells, as well as the cellular pathways involved in plaque development in the plaque microenvironment. Finally, it describes the plaque structural components and the role of factors involved in the rupture and erosion of plaques in the vessel.

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Long Non-coding RNA GAS5/miR-520-3p/SOCS3 Axis Regulates Inflammatory Response in Lipopolysaccharide-Induced Macrophages

Jiang

Wang

2022

Biochem Genet

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Correlations between vitronectin, miR-520, and miR-34 in patients with stenosis of coronary arteries

Cited by 5 publications

References 30 publications

miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach

miR-27a inhibits molecular adhesion between monocytes and human umbilical vein endothelial cells; systemic approach

Cellular crosstalk in atherosclerotic plaque microenvironment

Long Non-coding RNA GAS5/miR-520-3p/SOCS3 Axis Regulates Inflammatory Response in Lipopolysaccharide-Induced Macrophages

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